High-angle scattering events strongly affect light collection in clinically relevant measurement geometries for light transport through tissue

Physics in Medicine and Biology

Volumn 45, Issue 5, 2000, Pages 1127-1140

  Canpolat, Murat ^a   Mourant, Judith R ^a  

^a LOS ALAMOS NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; DIFFUSION COEFFICIENT; GEOMETRY; LIGHT SCATTERING; PHANTOM; PHOTON; PRIORITY JOURNAL; SYSTEM ANALYSIS;

BIOPHYSICS; HUMANS; LIGHT; MODELS, BIOLOGICAL; MONTE CARLO METHOD; SCATTERING, RADIATION;

EID: 0034033339     PISSN: 00319155     EISSN: None     Source Type: Journal    
DOI: 10.1088/0031-9155/45/5/304     Document Type: Article

References (27)

1. Bigio I J and Mourant J R 1997 Ultraviolet and visible spectroscopics for tissue diagnosis: fluorescence spectroscopy and elastic-scattering spectroscopy Phys. Med. Biol. 42 803-14
2. Bohren C F and Huffman D R 1983 Absorption and Scattering of Light by Small Particles (New York: Wiley)
3. Dunn A and Richards-Kortum R 1996 Three-dimensional computation of light scattering from cells IEEE J. Quantum Electron. 2 818-905
4. Drezek R, Dunn A and Richards-Kortum R 1999 Light scattering from cells: finite-difference time-domain simulations and goniometric measurements Appl. Opt. 38 3651-61
5. Fantini S, Franceschini M A and Gratton E 1994 Semi-infinite-geometry boundary problem for light migration in highly scattering media: a frequency-domain study in the diffusion approximation J. Opt. Soc. Am. B 11 2128-38
6. Farrell T J and Patterson M S 1992 A diffusion theory model of spatially resolved, steady-stale diffuse reflectance for the noninvasive determination of tissue optical properties in vivo Med. Phys. 19 879-88
7. Fishkin J B, Coquoz O, Anderson E R, Brenner M and Tromberg B J 1997 Frequency-domain photon migration measurements of normal and malignant-tissue optical-properties in a human subject Appl. Opt. 36 10-20
8. Ge Z, Schomacker K T and Nishioka N S 1998 Identification of colonic dysplasia and neoplasia by diffuse reflectance spectroscopy and pattern recognition techniques Appl. Spectrosc. 52 833-9
9. Haskell R C, Svaasand L O, Tsay T-T, Feng T C, McAdams M S and Tromberg B J 1994 Boundary conditions for the diffusion equation in radiative transfer J. Opt. Soc. Am. A 11 2727-41
10. Henyey L G and Greenstein JL 1941 Diffuse radiation in the galaxy Astrophys. J. 93 70-83
11. Jacques S L and Wang L 1995 Monte Carlo modeling of light transport in tissues Optical-Thermal Response of Laser Irradiated Tissue ed A J Welch and M J C van Gemert (New York: Plenum) pp 73-100
12. Marchesini R, Bertoni A, Andreola S, Melloni E and Sichirollo 1989 Extinction and absorption coefficients and scattering phase functions of human tissues in vitro Appl. Opt. 28 2318-24
13. Marquet P, Bevilacqua F, Depeursinge C and Haller E B 1995 Determination of reduced scattering and absorption coefficients by a single charge-coupled-device array measurement, part 1: comparison between experiments and simulations Opt. Eng. 34 2055-63
14. Mourant J R 1997 Monte Carlo investigations of the wavelength dependence of light transport through turbid media Proc. SPIE 3197 93-8
15. Mourant J R, Bigio I J, Boyer J, Conn R L, Johnson T and Shimada T 1995 Spectroscopic diagnosis of bladder-cancer with elastic light-scattering Lasers Surg. Med. 17 350-7
16. Mourant J R, Bigio I J, Boyer J, Johnson T M, Lacey J, Bohorfoush A G and Mellow M 1996a Elastic scattering spectroscopy as a diagnostic tool for differentiating pathologies in the gastrointestional tract: preliminary testing J. Biomed. Opt. 1 192-8
17. Mourant J R, Boyer J, Hielscher A H and Bigio I J 1996b Influence of the scattering phase function on light transport measurements in turbid media performed with small source-detector separations Opt. Lett 21 546-8
18. Mourant J R, Canpolat M, Brocker C, Esponda-Ramos O, Johnson T, Matanock A, Stetter K and Freyer J P 2000 Light scattering from cells: the contribution of the nucleus and the effects of proliferative status J. Biomed. Opt. 5 (2)
19. Mourant J R, Freyer J M, Hielscher A H, Eick A A, Shen D and Johnson T M 1998 Mechanisms of light scattering from biological cells relevant to non invasive optical-tissue diagnostics Appl. Opt. 37 3586-93
20. Perelman L T et al 1998 Observation of periodic fine structure in reflectance from biological tissue: a new technique for measuring nuclear size distribution Phys. Rev. Lett. 80 627-30
21. Pifferi A, Taroni P, Valentini G and Andersson-Engels S 1998 Real-time method for fitting time-resolved reflectance and transmittance measurement with a Monte Carlo model Appl. Opt. 37 2774-80
22. Saidi I S, Jacques S L and Tiltel F K 1995 Mic and Rayleigh modeling of visible-light scattering in neonatal skin Appl. Opt. 34 7410-18
23. Sokolov K, Drezek R, Gossage K and Richards-Kortum R 1999 Reflectance spectroscopy with polarized light: is it sensitive to cellular and nuclear morphology? Opt. Express 5 302-17
24. Venugopalan V, You J S and Tromberg B J 1998 Radiative transport in the diffusion approximation: an extension for highly absorbing media and small source-detector separations Phys. Rev. E 58 2395-407
25. Vo-Dinh T, Panjchpour M, Overholt B F, Farris C, Buckley F P III and Sneed R 1995 In vivo cancer diagnosis of cervical intraepithelial ncoplasia using 227-nm-excited laser-induced fluorescence Lasers Surg. Med. 16 41-7
26. Wang L H, Jacques S L and Zhcng L 1995 MCML: Monte-Carlo modeling of light transport in multilayered tissues Comput. Methods Programs Biomed. 47 131-46
27. Zonios G, Perelman L T, Backman V M, Manoharan R, Fitzmaurice M, VanDam J and Feld M S 1999 Diffuse reflectance spectroscopy for quantitative measurement of epithelial structures in situ Appl. Opt. 33 6628-37