Expression and function of rat urothelial P2Y receptors

American Journal of Physiology - Renal Physiology

Volumn 294, Issue 4, 2008, Pages

  Chopra, Bikramjit ^a   Gever, Joel ^b   Barrick, Stacey R ^a   Hanna Mitchell, Ann T ^a   Beckel, Jonathan M ^a   Ford, Anthony P D W ^b   Birder, Lori A ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b ROCHE BIOSCIENCE   (United States)

Author keywords

Epithelium; Lower urinary tract; Purinergic receptors; Urinary bladder

Indexed keywords

2 METHYLTHIOADENOSINE TRIPHOSPHATE; ACETYLCHOLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE 5' O (3 THIOTRIPHOSPHATE); ADENOSINE TRIPHOSPHATE; NITRIC OXIDE; PURINERGIC P2Y2 RECEPTOR; PURINERGIC P2Y4 RECEPTOR; URIDINE TRIPHOSPHATE; CALCIUM; PRIMER DNA; PURINERGIC P2 RECEPTOR;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; BLADDER EPITHELIUM; CALCIUM CELL LEVEL; IMMUNOCYTOCHEMISTRY; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; UROTHELIUM; ANIMAL; BLADDER; CELL CULTURE; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; IMMUNOHISTOCHEMISTRY; PHYSIOLOGY; POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT;

ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELLS, CULTURED; DNA PRIMERS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PURINERGIC P2; URINARY BLADDER; UROTHELIUM;

EID: 44949141639     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00321.2006     Document Type: Article

References (54)

1. Abbracchio MP, Boeynaems JM, Barnard EA, Boyer JL, Kennedy C, Miras-Portugal MT, King BF, Gachet C, Jacobson KA, Weisman GA, Burnstock G. Characterization of the UDP-glucose receptor (re-named here the P2Y14 receptor) adds diversity to the P2Y receptor family. Trends Pharmacol Sci 24: 52-55, 2003.
2. Apostolidis A, Popat R, Yiangou Y, Cockayne D, Ford AP, Davis JB, Dasgupta P, Fowler CJ, Anand P. Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. J Urol 174: 977-982, 2005.
3. Barnard EA, Burnstock G, Webb TE. G protein-coupled receptors for ATP and other nucleotides: a new receptor family. Trends Pharmacol Sci 15: 67-70, 1994.
4. Beckel JM, Meyers S, Giesselman BR, de Groat WC, Birder LA. Acetylcholine release from rat bladder epithelial cells and cholinergic modulation of bladder reflexes. Exp Biol Abstracts 863: 2, 2005.
5. Birder LA, Apodaca G, de Groat WC, Kanai AJ. Adrenergic- and capsaicin-evoked nitric oxide release from urothelium and afferent nerves in urinary bladder. Am J Physiol Renal Physiol 275: F226-F229, 1998.
6. Birder LA. Involvement of the urinary bladder urothelium in signaling in the lower urinary tract. Proc West Pharmacol Soc 44: 85-86, 2001.
7. Birder LA, Nealen ML, Kiss S, de Groat WC, Caterina MJ, Wang E, Apodaca G, Kanai AJ. Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. J Neurosci 22: 8063-8070, 2002.
8. Birder LA, Barrick SR, Roppolo JR, Kanai AJ, de Groat WC, Kiss S, Buffington CA. Feline interstitial cystitis results in mechanical hypersensitivity and altered ATP release from bladder urothelium. Am J Physiol Renal Physiol 285: F423-F429, 2003.
9. Birder LA, Ruan HZ, Chopra B, Xiang Z, Barrick S, Buffington CA, Roppolo JR, Ford AP, de Groat WC, Burnstock G. Alterations in P2X and P2Y purinergic receptor expression in urinary bladder from normal cats and cats with interstitial cystitis. Am J Physiol Renal Physiol 287: F1084-F1091, 2004.
10. Birder LA. More than just a barrier: urothelium as a drug target for urinary bladder pain. Am J Physiol Renal Physiol 289: F489-F495, 2005.
11. Birder LA. Role of the urothelium in urinary bladder dysfunction following spinal cord injury. Prog Brain Res 152: 135-146, 2006.
12. Boarder MR, Weisman GA, Turner JT, Wilkinson GF. G protein coupled P2 purinoceptors: from molecular biology to functional responses. Trends Pharmacol Sci 16: 133-139, 1995.
13. Brady CM, Apostolidis A, Yiangou Y, Baecker PA, Ford AP, Freeman A, Jacques TS, Fowler CJ, Anand P. P2X3-immunoreactive nerve fibres in neurogenic detrusor overactivity and the effect of intravesical resiniferatoxin. Eur Urol 46: 247-253, 2004.
14. Brunschweiger A, Muller CE. P2 receptors activated by uracil nucleotides - an update. Curr Med Chem 13: 289-312, 2006.
15. Chopra B, Barrick SR, Meyers S, Beckel JM, Zeidel ML, Ford AP, de Groat WC, Birder LA. Expression and function of bradykinin B1 and B2 receptors in normal and inflamed rat urinary bladder urothelium. J Physiol 562: 859-871, 2005.
16. Cockayne DA, Hamilton SG, Zhu QM, Dunn PM, Zhong Y, Novakovic S, Malmberg AB, Cain G, Berson A, Kassotakis L, Hedley L, Lachnit WG, Burnstock G, McMahon SB, Ford AP. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407: 1011-1015, 2000.
17. de Groat WC. The urothelium in overactive bladder: passive bystander or active participant? Urology 64: 7-11, 2004.
18. de Groat WC. Integrative control of the lower urinary tract : preclinical perspective. Br J Pharmacol 147: S25-S40, 2006.
19. de Groat WC, Yoshimura N. Mechanisms underlying the recovery of lower urinary tract function following spinal cord injury. Prog Brain Res 152: 59-84, 2006.
20. Downie JW, Karmazyn M. Mechanical trauma to bladder epithelium liberates prostanoids which modulate neurotransmission in rabbit detrusor muscle. J Pharmacol Exp Ther 230: 445-449, 1984.
21. Ferguson DR, Kennedy I, Burton TJ. ATP is released from rabbit urinary bladder epithelial cells by hydrostatic pressure changes - a possible sensory mechanism? J Physiol 505: 503-511, 1997.
22. Ford APDW, Gever JR, Nunn PA, Zhong Y, Cefalu JS, Dillon MP, Cockayne DA. Purinoceptors as therapeutic targets for lower urinary tract dysfunction. Br J Pharmacol 147: S132-S143, 2006.
23. Furuya K, Sokabe M, Furuya S. Characteristics of subepithelial fibroblasts as a mechano-sensor in the intestine: cell-shape-dependent ATP release and P2Y1 signaling. J Cell Sci 118: 3289-3304, 2005.
24. Gallagher CJ, Salter MW. Differential properties of astrocyte calcium waves mediated by P2Y1 and P2Y2 receptors. J Neurosci 23: 6728-6739, 2003.
25. Ishizuka O, Mattiasson A, Andersson KE. Tachykinin effects on bladder activity in conscious normal rats. J Urol 154: 257-261, 1995.
26. Jacobson KA, Costanzi S, Ivanov AA, Tchilibon S, Besada P, Gao ZG, Maddileti S, Harden TK. Structure activity and molecular modeling analyses of ribose- and base-modified uridine 5′-triphosphate analogues at the human P2Y2 and P2Y4 receptors. Biochem Pharmacol 71: 540-549, 2006.
27. Kasakov L, Burnstock G. The use of the slowly degradable analog, alpha, beta-methylene ATP, to produce desensitisation of the P2-purinoceptor: effect on non-adrenergic, non-cholinergic responses of the guinea-pig urinary bladder. Eur J Pharmacol 86: 291-294, 1982.
28. King BF, Knowles ID, Burnstock G, Ramage AG. Investigation of the effects of P2 purinoceptor ligands on the micturition reflex in female urethane-anaesthetized rats. Br J Pharmacol 142: 519-530, 2004.
29. Lazzeri M. The physiological function of the urothelium - more than a simple barrier. Urol Int 76: 289-295, 2006.
30. Lee HY, Bardini M, Burnstock G. Distribution of P2X receptors in the urinary bladder and the ureter of the rat. J Urol 163: 2002-2007, 2000.
31. Lewis SA, Lewis JR. Kinetics of urothelial ATP release. Am J Physiol Renal Physiol 291: F332-F340, 2006.
32. Maggi CA. Prostanoids as local modulators of reflex micturition. Pharmacol Res 25: 13-20, 1992.
33. Moore KH, Ray FR, Barden JA. Loss of purinergic P2X(3) and P2X(5) receptor innervation in human detrusor from adults with urge incontinence. J Neurosci 21: RC166, 2001.
34. Namasivayam S, Eardley I, Morrison JF. Purinergic sensory neurotransmission in the urinary bladder: an in vitro study in the rat. BJU Int 84: 854-860, 1999.
35. O'Reilly BA, Kosaka AH, Chang TK, Ford AP, Popert R, Rymer JM, McMahon SB. A quantitative analysis of purinoceptor expression in human fetal and adult bladders. J Urol 165: 1730-1734, 2001.
36. O'Reilly BA, Kosaka AH, Knight GF, Chang TK, Ford AP, Rymer JM, Popert R, Burnstock G, McMahon SB. P2X receptors and their role in female idiopathic detrusor instability. J Urol 167: 157-164, 2002.
37. Obara K, Lepor H, Walden PD. Localization of P2Y1 purinoceptor transcripts in the rat penis and urinary bladder. J Urol 160: 587-591, 1998.
38. Palea S, Artibani W, Ostardo E, Trist DG, Pietra C. Evidence for purinergic neurotransmission in human urinary bladder affected by interstitial cystitis. J Urol 150: 2007-2012, 1993.
39. Powell DW, Mifflin RC, Valentich JD, Crowe SE, Saada JI, West AB. Myofibroblasts. II. Intestinal subepithelial myofibroblasts. Am J Physiol Cell Physiol 277: C183-C201, 1999.
40. Rong W, Spyer KM, Burnstock G. Activation and sensitisation of low and high threshold afferent fibres mediated by P2X receptors in the mouse urinary bladder. J Physiol 541: 591-600, 2002.
41. Sak K, Illes P. Neuronal and glial cell lines as model systems for studying P2Y receptor pharmacology. Neurochem Int 47: 401-412, 2005.
42. Stucky CL, Medler KA, Molliver DC. The P2Y agonist UTP activates cutaneous afferent fibers. Pain 109: 36-44, 2004.
43. Sui GP, Wu C, Fry CH. Characterization of the purinergic receptor subtype on guinea-pig suburothelial myofibroblasts. BJU Int 97: 1327-1331, 2006.
44. Sun Y, Keay S, DeDeyne P, Chai T. Stretch-activated release of adenosine triphosphate by bladder uroepithelia is augmented in interstitial cystitis. Urology 57: 131, 2001.
45. Sun Y, Chai TC. Augmented extracellular ATP signaling in bladder urothelial cells from patients with interstitial cystitis. Am J Physiol Cell Physiol 290: C27-C34, 2006.
46. Tempest HV, Dixon AK, Turner WH, Elneil S, Sellers LA, Ferguson DR. P2X and P2X receptor expression in human bladder urothelium and changes in interstitial cystitis. BJU Int 93: 1344-1248, 2004.
47. Truschel ST, Ruiz WG, Shulman T, Pilewski J, Sun TT, Zeidel ML, Apodaca G. Primary uroepithelial cultures. A model system to analyze umbrella cell barrier function. J Biol Chem 274: 15020-15029, 1999.
48. Vial C, Evans RJ. P2X receptor expression in mouse urinary bladder and the requirement of P2X(1) receptors for functional P2X receptor responses in the mouse urinary bladder smooth muscle. Br J Pharmacol 131: 1489-1495, 2000.
49. Vlaskovska M, Kasakov L, Rong W, Bodin P, Bardini M, Cockayne DA, Ford AP, Burnstock G. P2X3 knock-out mice reveal a major sensory role for urothelially released ATP. J Neurosci 21: 5670-5677, 2001.
50. Wang EC, Lee JM, Ruiz WG, Balestreire EM, von Bodungen M, Barrick S, Cockayne DA, Birder LA, Apodaca G. ATP and purinergic-dependent membrane traffic in bladder umbrella cells. J Clin Invest 115: 2412-2422, 2005.
51. Wein AJ. The urothelium in overactive bladder: passive bystander or active participant? J Urol 173: 2199-2200, 2005.
52. 2+ ions. Br J Pharmacol 140: 1177-1186, 2003.
53. Wiseman OJ, Fowler CJ, Landon DN. The role of the human bladder lamina propria myofibroblast. BJU Int 91: 89-93, 2003.
54. Yu W, Zacharia LC, Jackson EK, Apodaca G. Adenosine receptor expression and function in bladder uroepithelium. Am J Physiol Cell Physiol 291: C254-C265, 2006.