The lipoprotein subtraction profile: Heritability and identification of quantitative trait loci

Journal of Lipid Research

Volumn 49, Issue 4, 2008, Pages 715-723

  Kaess, Bernhard ^a   Fischer, Marcus ^a   Baessler, Andrea ^a   Stark, Klaus ^a   Huber, Fritz ^b   Kremer, Werner ^b   Kalbitzer, Hans Robert ^b   Schunkert, Heribert ^c   Riegger, Guenter ^a   Hengstenberg, Christian ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b UNIVERSITY OF REGENSBURG   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

HDL; LDL; Linkage analysis; Subclasses nmr spectroscopy

Indexed keywords

HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LIPOPROTEIN;

ADULT; ARTICLE; CHROMOSOME 12; CHROMOSOME 18; CONTROLLED STUDY; CORONARY ARTERY DISEASE; FEMALE; GENETIC LINKAGE; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; PARTICLE SIZE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; CLASSIFICATION; FAMILY; GENETICS; GENOME; METABOLISM; MIDDLE AGED; QUANTITATIVE TRAIT;

FAMILY; FEMALE; GENOME, HUMAN; HUMANS; LIPOPROTEINS; MALE; MIDDLE AGED; PARTICLE SIZE; QUANTITATIVE TRAIT LOCI; QUANTITATIVE TRAIT, HERITABLE;

EID: 44949140832     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M700338-JLR200     Document Type: Article

References (56)

1. Adult Treatment Panel III. 2002. Third report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 106: 3163-3184.
2. Otvos, J. D., D. Collins, D. S. Freedman, I. Shalaurova, E. J. Schaefer, J. R. McNamara, H. E. Bloomfield, and S. J. Robins. 2006. Low-density lipoprotein and high-density lipoprotein particle subclasses predict coronary events and are favorably changed by gemfibrozil therapy in the Veterans Affairs High-Density Lipoprotein Intervention Trial. Circulation. 113: 1556-1563.
3. Freedman, D. S., J. D. Otvos, E. J. Jeyarajah, J. J. Barboriak, A. J. Anderson, and J. A. Walker. 1998. Relation of lipoprotein subclasses as measured by proton nuclear magnetic resonance spectroscopy to coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 18: 1046-1053.
4. Rosenson, R. S., J. D. Otvos, and D. S. Freedman. 2002. Relations of lipoprotein subclass levels and low-density lipoprotein size to progression of coronary artery disease in the Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC-I) Trial. Am. J. Cardiol. 90: 89-94.
5. Berneis, K. K., and R. M. Krauss. 2002. Metabolic origins and clinical significance of LDL heterogeneity. J. Lipid Res. 43: 1363-1379.
6. Lamarche, B., A. C. St-Pierre, I. L. Ruel, B. Cantin, G. R. Dagenais, and J. P. Despres. 2001. A prospective, population-based study of low density lipoprotein particle size as a risk factor for ischemic heart disease in men. Can. J. Cardiol. 17: 859-865.
7. Stampfer, M. J., R. M. Krauss, J. Ma, P. J. Blanche, L. G. Holl, F. M. Sacks, and C. H. Hennekens. 1996. A prospective study of triglyceride level, low-density lipoprotein particle diameter, and risk of myocardial infarction. J. Am. Med. Assoc. 276: 882-888.
8. Kuller, L., A. Arnold, R. Tracy, J. Otvos, G. Burke, B. Psaty, D. Siscovick, D. S. Freedman, and R. Kronmal. 2002. Nuclear magnetic resonance spectroscopy of lipoproteins and risk of coronary heart disease in the Cardiovascular Health Study. Arterioscler. Thromb. Vasc. Biol. 22: 1175-1180.
9. ElHarchaoui,K.,W.A.vanderSteeg,E.S.Stroes,J.A. Kuivenhoven, J. D. Otvos, N. J. Wareham, B. A. Hutten, J. J. Kastelein, K. T. Khaw, and S. M. Boekholdt. 2007. Value of low-density lipoprotein particle number and size as predictors of coronary artery disease in apparently healthy men and women: the EPIC-Norfolk Prospective Population Study. J. Am. Coll. Cardiol. 49: 547-553.
10. Asztalos, B. F., L. A. Cupples, S. Demissie, K. V. Horvath, C. E. Cox, M. C. Batista, and E. J. Schaefer. 2004. High-density lipoprotein subpopulation profile and coronary heart disease prevalence in male participants of the Framingham Offspring Study. Arterioscler. Thromb. Vasc. Biol. 24: 2181-2187.
11. Asztalos, B. F., D. Collins, L. A. Cupples, S. Demissie, K. V. Horvath, H. E. Bloomfield, S. J. Robins, and E. J. Schaefer. 2005. Value of high-density lipoprotein (HDL) subpopulations in predicting recurrent cardiovascular events in the Veterans Affairs HDL Intervention Trial. Arterioscler. Thromb. Vasc. Biol. 25: 2185-2191.
12. Lamarche, B., S. Moorjani, B. Cantin, G. R. Dagenais, P. J. Lupien, and J. P. Despres. 1997. Associations of HDL2 and HDL3 subfractions with ischemic heart disease in men. Prospective results from the Quebec Cardiovascular Study. Arterioscler. Thromb. Vasc. Biol. 17: 1098-1105.
13. Broeckel, U., C. Hengstenberg, B. Mayer, S. Holmer, L. J. Martin, A. G. Comuzzie, J. Blangero, P. Nurnberg, A. Reis, G. A. Riegger, et al. 2002. Acomprehensive linkage analysis for myocardial infarction and its related risk factors. Nat. Genet. 30: 210-214.
14. Almasy, L., and J. Blangero. 1998. Multipoint quantitative-trait linkage analysis in general pedigrees. Am. J. Hum. Genet. 62: 1198-1211.
15. Baessler, A., M. Fischer, V. Huf, S. Mell, C. Hengstenberg, B. Mayer, S. Holmer, G. Riegger, and H. Schunkert. 2005. Failure to achieve recommended LDL cholesterol levels by suboptimal statin therapy relates to elevated cardiac event rates. Int. J. Cardiol. 101: 293-298.
16. Almasy, L., T. D. Dyer, and J. Blangero. 1997. Bivariate quantitative trait linkage analysis: pleiotropy versus co-incident linkages. Genet. Epidemiol. 14: 953-958.
17. Williams, J. T., P. Van Eerdewegh, L. Almasy, and J. Blangero. 1999. Joint multipoint linkage analysis of multivariate qualitative and quantitative traits. I. Likelihood formulation and simulation results. Am. J. Hum. Genet. 65: 1134-1147.
18. Heller, D. A., U. de Faire, N. L. Pedersen, G. Dahlen, and G. E. McClearn. 1993. Genetic and environmental influences on serum lipid levels in twins. N. Engl. J. Med. 328: 1150-1156.
19. Bosse, Y., L. Perusse, and M. C. Vohl. 2004. Genetics of LDL particle heterogeneity: from genetic epidemiology to DNA-based variations. J. Lipid Res. 45: 1008-1026.
20. O'Connell, D. L., R. F. Heller, D. C. Roberts,J. R. Allen,J. C. Knapp, P. L. Steele, and D. Silove. 1988. Twin study of genetic and environmental effects on lipid levels. Genet. Epidemiol. 5: 323-341.
21. Bo, S., P. Cavallo-Perin, L. Scaglione, and G. Pagano. 1997. Heritability of cardiovascular risk parameters in subjects with increased susceptibility to non-insulin-dependent diabetes mellitus. Acta Diabetol. 34: 280-284.
22. Kuusi, T., Y. A. Kesaniemi, M. Vuoristo, T. A. Miettinen, and M. Koskenvuo. 1987. Inheritance of high density lipoprotein and lipoprotein lipase and hepatic lipase activity. Arteriosclerosis. 7: 421-425.
23. Bosse, Y., Y. C. Chagnon, J. P. Despres, T. Rice, D. C. Rao, C. Bouchard, L. Perusse, and M. C. Vohl. 2004. Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome- wide search of apolipoprotein levels. J. Lipid Res. 45: 2174-2184.
24. Couture, P., J. D. Otvos, L. A. Cupples, C. Lahoz, P. W. Wilson, E. J. Schaefer, and J. M. Ordovas. 2000. Association of the C-514T polymorphism in the hepatic lipase gene with variations in lipoprotein subclass profiles: the Framingham Offspring Study. Arterioscler. Thromb. Vasc. Biol. 20: 815-822.
25. De Oliveira e Silva, E. R., M. Kong, Z. Han, C. Starr, E. M. Kass, S. H. Juo, D. Foster, H. M. Dansky, M. Merkel, K. Cundey, et al. 1999. Metabolic and genetic determinants of HDL metabolism and hepatic lipase activity in normolipidemic females. J. Lipid Res. 40: 1211-1221.
26. Ordovas, J. M., D. Corella, S. Demissie, L. A. Cupples, P. Couture, O. Coltell, P. W. Wilson, E. J. Schaefer, and K. L. Tucker. 2002. Dietary fat intake determines the effect of a common polymorphism in the hepatic lipase gene promoter on high-density lipoprotein metabolism: evidence of a strong dose effect in this gene- nutrient interaction in the Framingham Study. Circulation. 106: 2315-2321.
27. Hutter, C. M., M. A. Austin, F. M. Farin, H. M. Viernes, K L. Edwards, D. L. Leonetti, M. J. McNeely, and W. Y. Fujimoto. 2006. Association of endothelial lipase gene (LIPG) haplotypes with high- density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans. Atherosclerosis. 185: 78-86.
28. Brousseau, T., A. M. Dupuy-Gorce, A. Evans, D. Arveiler, J. B. Ruidavets, B. Haas, J. P. Cambou, G. Luc, P. Ducimetiere, P. Amouyel, et al. 2002. Significant impact of the highly informative (CA)n repeat polymorphism of the APOA-II gene on the plasma APOA-II concentrations and HDL subfractions: the ECTIM Study. Am. J. Med. Genet. 110: 19-24.
29. Kamboh, M. I., S. Iyengar, C. E. Aston, R. F. Hamman, and R. E. Ferrell. 1992. Apolipoprotein A-IV genetic polymorphism and its impact on quantitative traits in normoglycemic and non-insulin-dependent diabetic Hispanics from the San Luis Valley, Colorado. Hum. Biol. 64: 605-616.
30. Russo, G. T., J. B. Meigs, L. A. Cupples, S. Demissie, J. D. Otvos, P. W. Wilson, C. Lahoz, D. Cucinotta, P. Couture, T. Mallory, et al. 2001. Association of the Sst-I polymorphism at the APOC3 gene locus with variations in lipid levels, lipoprotein subclass profiles and coronary heart disease risk: the Framingham Offspring Study. Atherosclerosis. 158: 173-181.
31. Carr, M. C., A. F. Ayyobi, S. J. Murdoch, S. S. Deeb, and J. D. Brunzell. 2002. Contribution of hepatic lipase, lipoprotein lipase, and cholesteryl ester transfer protein to LDL and HDL heterogeneity in healthy women. Arterioscler. Thromb. Vasc. Biol. 22: 667-673.
32. Isasi, C. R., S. Shea, R. J. Deckelbaum, S. C. Couch, T. J. Starc, J. D. Otvos, and L. Berglund. 2000. Apolipoprotein epsilon2 allele is associated with an anti-atherogenic lipoprotein profile in children: the Columbia University BioMarkers Study. Pediatrics. 106: 568-575.
33. Rainwater, D. L., J. Blangero, J. E. Hixson, S. Birnbaum, G. E. Mott, and J. L. VandeBerg. 1992. A DNA polymorphism for LCAT is associated with altered LCAT activity and high density lipoprotein size distributions in baboons. Arterioscler. Thromb. 12: 682-690.
34. Hayek, T., N. Azrolan, R. B. Verdery, A. Walsh, T. Chajek-Shaul, L. B. Agellon, A. R. Tall, and J. L. Breslow. 1993. Hypertriglyceridemia and cholesteryl ester transfer protein interact to dramatically alter high density lipoprotein levels, particle sizes, and metabolism. Studies in transgenic mice. J. Clin. Invest. 92: 1143-1152.
35. Almasy, L., J. E. Hixson, D. L. Rainwater, S. Cole, J. T. Williams, M. C. Mahaney, J. L. VandeBerg, M. P. Stern, J. W. MacCluer, and J. Blangero. 1999. Human pedigree-based quantitative-trait-locus mapping: localization of two genes influencing HDL-cholesterol metabolism. Am. J. Hum. Genet. 64: 1686-1693.
36. Yang, Q., C. Q. Lai, L. Parnell, L. A. Cupples, X. Adiconis, Y. Zhu, P. W. Wilson, D. E. Housman, A. M. Shearman, R. B. D'Agostino, et al. 2005. Genome-wide linkage analyses and candidate gene fine mapping for HDL3 cholesterol: the Framingham Study. J. Lipid Res. 46: 1416-1425.
37. Bielinski, S. J., W. Tang, J. S. Pankow, M. B. Miller, T. H. Mosley, E. Boerwinkle, R. A. Olshen, J. D. Curb, C. E. Jaquish, D. C. Rao, et al. 2006. Genome-wide linkage scans for loci affecting total cholesterol, HDL-C, and triglycerides: the Family Blood Pressure Program. Hum. Genet. 120: 371-380.
38. Oh, W., L. Abu-Elheiga, P. Kordari, Z. Gu, T. Shaikenov, S. S. Chirala, and S. J. Wakil. 2005. Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice. Proc. Natl. Acad. Sci. USA. 102: 1384-1389.
39. Harwood, H. J., Jr. 2005. Treating the metabolic syndrome: acetyl-CoA carboxylase inhibition. Expert Opin. Ther. Targets. 9: 267-281.
40. Chen, C. H., C. J. Chang, W. S. Yang, C. L. Chen, and C. S. Fann. 2003. A genome-wide scan using tree-based association analysis for candidate loci related to fasting plasma glucose levels. BMC Genet. 4(Suppl. 1): S65.
41. Cone, R. D. 2005. Anatomy and regulation of the central melanocortin system. Nat. Neurosci. 8: 571-578.
42. Austin, M. A., J. L. Breslow, C. H. Hennekens, J. E. Buring, W. C. Willett, and R. M. Krauss. 1988. Low-density lipoprotein subclass patterns and risk of myocardial infarction. J. Am. Med. Assoc. 260: 1917-1921.
43. Campos, H., J. J. Genest, Jr., E. Blijlevens, J. R. McNamara, J. L. Jenner, J. M. Ordovas, P. W. Wilson, and E. J. Schaefer. 1992. Low density lipoprotein particle size and coronary artery disease. Arterioscler. Thromb. 12: 187-195.
44. Campos, H., E. Blijlevens, J. R. McNamara, J. M. Ordovas, B. M. Posner, P. W. Wilson, W. P. Castelli, and E. J. Schaefer. 1992. LDL particle size distribution. Results from the Framingham Offspring Study. Arterioscler. Thromb. 12: 1410-1419.
45. Austin, M. A., J. D. Brunzell, W. L. Fitch, and R. M. Krauss. 1990. Inheritance of low density lipoprotein subclass patterns in familial combined hyperlipidemia. Arteriosclerosis. 10: 520-530.
46. Rizzo, M., and K. Berneis. 2006. Low-density lipoprotein size and cardiovascular risk assessment. Q JM. 99: 1-14.
47. Stampfer, M. J., F. M. Sacks, S. Salvini, W. C. Willett, and C. H. Hennekens. 1991. A prospective study of cholesterol, apolipoproteins, and the risk of myocardial infarction. N. Engl. J. Med. 325: 373-381.
48. Sweetnam, P. M., C. H. Bolton, J. W. Yarnell, D. Bainton, I. A. Baker, P. C. Elwood, and N. E. Miller. 1994. Associations of the HDL2 and HDL3 cholesterol subfractions with the development of ischemic heart disease in British men. The Caerphilly and Speedwell Collaborative Heart Disease Studies. Circulation. 90: 769-774.
49. Kempen, H. J., C. M. van Gent, R. Buytenhek, and B. Buis. 1987. Association of cholesterol concentrations in low-density lipoprotein, high-density lipoprotein, and high-density lipoprotein sub- fractions, and of apolipoproteins AI and AII, with coronary stenosis and left ventricular function. J. Lab. Clin. Med. 109: 19-26.
50. Campos, H., G. O. Roederer, S. Lussier-Cacan, J. Davignon, and R. M. Krauss. 1995. Predominance of large LDL and reduced HDL2 cholesterol in normolipidemic men with coronary artery disease. Arterioscler. Thromb. Vasc. Biol. 15: 1043-1048.
51. Nicholls, S. J., K. A. Rye, and P. J. Barter. 2005. High-density lipoproteins as therapeutic targets. Curr. Opin. Lipidol. 16: 345-349.
52. Soedamah-Muthu, S. S., Y. F. Chang, J. Otvos, R. W. Evans, and T. J. Orchard. 2003. Lipoprotein subclass measurements by nuclear magnetic resonance spectroscopy improve the prediction of coronary artery disease in type 1 diabetes. Aprospective report from the Pittsburgh Epidemiology of Diabetes Complications Study. Diabetologia. 46: 674-682.
53. Soedamah-Muthu, S. S., H. M. Colhoun, M. J. Thomason, D. J. Betteridge, P. N. Durrington, G. A. Hitman, J. H. Fuller, K. Julier, M. I. Mackness, and H. A. Neil. 2003. The effect of atorvastatin on serum lipids, lipoproteins and NMR spectroscopy defined lipoprotein subclasses in type 2 diabetic patients with ischaemic heart disease. Atherosclerosis. 167: 243-255.
54. Lawrence, J. M., J. Reid, G. J. Taylor, C. Stirling, and J. P. Reckless. 2004. The effect of high dose atorvastatin therapy on lipids and lipoprotein subfractions in overweight patients with type 2 diabetes. Atherosclerosis. 174: 141-149.
55. Otvos, J. D., I. Shalaurova, D. S. Freedman, and R. S. Rosenson. 2002. Effects of pravastatin treatment on lipoprotein subclass profiles and particle size in the PLAC-I trial. Atherosclerosis. 160: 41-48.
56. Freeman, M. S., M. W. Mansfield, J. H. Barrett, and P. J. Grant. 2002. Heritability offeatures ofthe insulin resistance syndrome in a community-based study of healthy families. Diabet. Med. 19: 994-999.