메뉴 건너뛰기




Volumn 68, Issue 9, 2008, Pages 975-984

Inactivation of the NF2 tumor suppressor protein merlin in DU145 prostate cancer cells

Author keywords

Phosphorylation; Prostate cancer; Tumor suppressor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; GROWTH FACTOR; HERMES ANTIGEN; HYALURONIC ACID; MERLIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; N BENZYL 2 CYANO 3 (3,4 DIHYDROXYPHENYL)ACRYLAMIDE; NSC 23766; P21 ACTIVATED KINASE; PROTEIN KINASE INHIBITOR; SERINE; TUMOR SUPPRESSOR PROTEIN;

EID: 44849133669     PISSN: 02704137     EISSN: 10970045     Source Type: Journal    
DOI: 10.1002/pros.20760     Document Type: Article
Times cited : (31)

References (51)
  • 2
    • 0032522603 scopus 로고    scopus 로고
    • Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors
    • McClatchey AI, Saotome I, Mercer K, Crowley D, Gusella JF, Bronson RT, Jacks T. Mice heterozygous for a mutation at the Nf2 tumor suppressor locus develop a range of highly metastatic tumors. Genes Dev 1998;12(8):1121-1133.
    • (1998) Genes Dev , vol.12 , Issue.8 , pp. 1121-1133
    • McClatchey, A.I.1    Saotome, I.2    Mercer, K.3    Crowley, D.4    Gusella, J.F.5    Bronson, R.T.6    Jacks, T.7
  • 3
    • 0001387683 scopus 로고    scopus 로고
    • Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: Evidence for a two-hit mechanism of NF2 inactivation
    • Cheng JQ, Lee WC, Klein MA, Cheng GZ, Jhanwar SC, Testa JR. Frequent mutations of NF2 and allelic loss from chromosome band 22q12 in malignant mesothelioma: Evidence for a two-hit mechanism of NF2 inactivation. Genes Chromosomes Cancer 1999;24(3):238-242.
    • (1999) Genes Chromosomes Cancer , vol.24 , Issue.3 , pp. 238-242
    • Cheng, J.Q.1    Lee, W.C.2    Klein, M.A.3    Cheng, G.Z.4    Jhanwar, S.C.5    Testa, J.R.6
  • 4
    • 0037155867 scopus 로고    scopus 로고
    • Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain
    • Shimizu T, Seto A, Maita N, Hamada K, Tsukita S, Hakoshima T. Structural basis for neurofibromatosis type 2. Crystal structure of the merlin FERM domain. J Biol Chem 2002;277(12):10332-10336.
    • (2002) J Biol Chem , vol.277 , Issue.12 , pp. 10332-10336
    • Shimizu, T.1    Seto, A.2    Maita, N.3    Hamada, K.4    Tsukita, S.5    Hakoshima, T.6
  • 5
    • 0032559637 scopus 로고    scopus 로고
    • Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2
    • Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S. Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43, and ICAM-2. J Cell Biol 1998;140(4):885-895.
    • (1998) J Cell Biol , vol.140 , Issue.4 , pp. 885-895
    • Yonemura, S.1    Hirao, M.2    Doi, Y.3    Takahashi, N.4    Kondo, T.5    Tsukita, S.6
  • 7
    • 0033607687 scopus 로고    scopus 로고
    • Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF
    • Gonzalez-Agosti C, Wiederhold T, Herndon ME, Gusella J, Ramesh V. Interdomain interaction of merlin isoforms and its influence on intermolecular binding to NHE-RF. J Biol Chem 1999;274(48):34438-34442.
    • (1999) J Biol Chem , vol.274 , Issue.48 , pp. 34438-34442
    • Gonzalez-Agosti, C.1    Wiederhold, T.2    Herndon, M.E.3    Gusella, J.4    Ramesh, V.5
  • 8
    • 0035831501 scopus 로고    scopus 로고
    • Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP
    • Nguyen R, Reczek D, Bretscher A. Hierarchy of merlin and ezrin N- and C-terminal domain interactions in homo- and heterotypic associations and their relationship to binding of scaffolding proteins EBP50 and E3KARP. J Biol Chem 2001;276(10):7621-7629.
    • (2001) J Biol Chem , vol.276 , Issue.10 , pp. 7621-7629
    • Nguyen, R.1    Reczek, D.2    Bretscher, A.3
  • 9
    • 0032567361 scopus 로고    scopus 로고
    • Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures
    • Oshiro N, Fukata Y, Kaibuchi K. Phosphorylation of moesin by rho-associated kinase (Rho-kinase) plays a crucial role in the formation of microvilli-like structures. J Biol Chem 1998;273(52):34663-34666.
    • (1998) J Biol Chem , vol.273 , Issue.52 , pp. 34663-34666
    • Oshiro, N.1    Fukata, Y.2    Kaibuchi, K.3
  • 11
    • 2442629479 scopus 로고    scopus 로고
    • Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization
    • Alfthan K, Heiska L, Gronholm M, Renkema GH, Carpen O. Cyclic AMP-dependent protein kinase phosphorylates merlin at serine 518 independently of p21-activated kinase and promotes merlin-ezrin heterodimerization. J Biol Chem 2004;279(18):18559-18566.
    • (2004) J Biol Chem , vol.279 , Issue.18 , pp. 18559-18566
    • Alfthan, K.1    Heiska, L.2    Gronholm, M.3    Renkema, G.H.4    Carpen, O.5
  • 12
    • 0038077566 scopus 로고    scopus 로고
    • NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions
    • Lallemand D, Curto M, Saotome I, Giovannini M, McClatchey AI. NF2 deficiency promotes tumorigenesis and metastasis by destabilizing adherens junctions. Genes Dev 2003;17(9):1090-1100.
    • (2003) Genes Dev , vol.17 , Issue.9 , pp. 1090-1100
    • Lallemand, D.1    Curto, M.2    Saotome, I.3    Giovannini, M.4    McClatchey, A.I.5
  • 13
    • 0032571272 scopus 로고    scopus 로고
    • Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli
    • Shaw RJ, McClatchey AI, Jacks T. Regulation of the neurofibromatosis type 2 tumor suppressor protein, merlin, by adhesion and growth arrest stimuli. J Biol Chem 1998;273(13):7757-7764.
    • (1998) J Biol Chem , vol.273 , Issue.13 , pp. 7757-7764
    • Shaw, R.J.1    McClatchey, A.I.2    Jacks, T.3
  • 14
    • 1642564499 scopus 로고    scopus 로고
    • Direct binding of neutral endopeptidase 24.11 to ezrin/radixin/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins
    • Iwase A, Shen R, Navarro D, Nanus DM. Direct binding of neutral endopeptidase 24.11 to ezrin/radixin/moesin (ERM) proteins competes with the interaction of CD44 with ERM proteins. J Biol Chem 2004;279(12):11898-11905.
    • (2004) J Biol Chem , vol.279 , Issue.12 , pp. 11898-11905
    • Iwase, A.1    Shen, R.2    Navarro, D.3    Nanus, D.M.4
  • 15
    • 27144490037 scopus 로고    scopus 로고
    • Ezrin expression in prostate cancer and benign prostatic tissue
    • Valdman A, Fang X, Pang ST, Nilsson B, Ekman P, Egevad L. Ezrin expression in prostate cancer and benign prostatic tissue. Eur Urol 2005;48(5):852-857.
    • (2005) Eur Urol , vol.48 , Issue.5 , pp. 852-857
    • Valdman, A.1    Fang, X.2    Pang, S.T.3    Nilsson, B.4    Ekman, P.5    Egevad, L.6
  • 17
    • 2942675416 scopus 로고    scopus 로고
    • PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition
    • Nheu T, He H, Hirokawa Y, Walker F, Wood J, Maruta H. PAK is essential for RAS-induced upregulation of cyclin D1 during the G1 to S transition. Cell Cycle 2004;3(1):71-74.
    • (2004) Cell Cycle , vol.3 , Issue.1 , pp. 71-74
    • Nheu, T.1    He, H.2    Hirokawa, Y.3    Walker, F.4    Wood, J.5    Maruta, H.6
  • 18
    • 11144238571 scopus 로고    scopus 로고
    • 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer metastasis
    • Horiguchi A, Sumitomo M, Asakuma J, Asano T, Hayakawa M. 3-hydroxy-3-methylglutaryl-coenzyme a reductase inhibitor, fluvastatin, as a novel agent for prophylaxis of renal cancer metastasis. Clin Cancer Res 2004;10(24):8648-8655.
    • (2004) Clin Cancer Res , vol.10 , Issue.24 , pp. 8648-8655
    • Horiguchi, A.1    Sumitomo, M.2    Asakuma, J.3    Asano, T.4    Hayakawa, M.5
  • 19
    • 0035418151 scopus 로고    scopus 로고
    • TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin
    • van Bokhoven A, Varella-Garcia M, Korch C, Miller GJ. TSU-Pr1 and JCA-1 cells are derivatives of T24 bladder carcinoma cells and are not of prostatic origin. Cancer Res 2001;61(17):6340-6344.
    • (2001) Cancer Res , vol.61 , Issue.17 , pp. 6340-6344
    • van Bokhoven, A.1    Varella-Garcia, M.2    Korch, C.3    Miller, G.J.4
  • 20
    • 7244247060 scopus 로고    scopus 로고
    • Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation
    • Lee JH, Katakai T, Hara T, Gonda H, Sugai M, Shimizu A. Roles of p-ERM and Rho-ROCK signaling in lymphocyte polarity and uropod formation. J Cell Biol 2004;167(2):327-337.
    • (2004) J Cell Biol , vol.167 , Issue.2 , pp. 327-337
    • Lee, J.H.1    Katakai, T.2    Hara, T.3    Gonda, H.4    Sugai, M.5    Shimizu, A.6
  • 21
    • 30744433331 scopus 로고    scopus 로고
    • Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells
    • Koss M, Pfeiffer GRII, Wang Y, Thomas ST, Yerukhimovich M, Gaarde WA, Doerschuk CM, Wang Q. Ezrin/radixin/moesin proteins are phosphorylated by TNF-alpha and modulate permeability increases in human pulmonary microvascular endothelial cells. J Immunol 2006;176(2):1218-1227.
    • (2006) J Immunol , vol.176 , Issue.2 , pp. 1218-1227
    • Koss, M.1    GRII, P.2    Wang, Y.3    Thomas, S.T.4    Yerukhimovich, M.5    Gaarde, W.A.6    Doerschuk, C.M.7    Wang, Q.8
  • 22
    • 0033941950 scopus 로고    scopus 로고
    • CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor
    • discussion 118-120
    • Herrlich P, Morrison H, Sleeman J, Orian-Rousseau V, Konig H, Weg-Remers S, Ponta H. CD44 acts both as a growth- and invasiveness-promoting molecule and as a tumor-suppressing cofactor. Ann NY Acad Sci 2000;910:106-118; discussion 118-120.
    • (2000) Ann NY Acad Sci , vol.910 , pp. 106-118
    • Herrlich, P.1    Morrison, H.2    Sleeman, J.3    Orian-Rousseau, V.4    Konig, H.5    Weg-Remers, S.6    Ponta, H.7
  • 23
    • 0031964774 scopus 로고    scopus 로고
    • Impaired interaction of naturally occurring mutant NF2 protein with actin-based cytoskeleton and membrane
    • Deguen B, Merel P, Goutebroze L, Giovannini M, Reggio H, Arpin M, Thomas G. Impaired interaction of naturally occurring mutant NF2 protein with actin-based cytoskeleton and membrane. Hum Mol Genet 1998;7(2):217-226.
    • (1998) Hum Mol Genet , vol.7 , Issue.2 , pp. 217-226
    • Deguen, B.1    Merel, P.2    Goutebroze, L.3    Giovannini, M.4    Reggio, H.5    Arpin, M.6    Thomas, G.7
  • 24
    • 0037096169 scopus 로고    scopus 로고
    • Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: An essential role for polyphosphoinositides in vivo
    • Yonemura S, Matsui T, Tsukita S. Rho-dependent and -independent activation mechanisms of ezrin/radixin/moesin proteins: An essential role for polyphosphoinositides in vivo. J Cell Sci 2002;115(Pt 12):2569-2580.
    • (2002) J Cell Sci , vol.115 , Issue.PART 12 , pp. 2569-2580
    • Yonemura, S.1    Matsui, T.2    Tsukita, S.3
  • 26
    • 0038180913 scopus 로고    scopus 로고
    • Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer
    • Posey JT, Soloway MS, Ekici S, Sofer M, Civantos F, Duncan RC, Lokeshwar VB. Evaluation of the prognostic potential of hyaluronic acid and hyaluronidase (HYAL1) for prostate cancer. Cancer Res 2003;63(10):2638-2644.
    • (2003) Cancer Res , vol.63 , Issue.10 , pp. 2638-2644
    • Posey, J.T.1    Soloway, M.S.2    Ekici, S.3    Sofer, M.4    Civantos, F.5    Duncan, R.C.6    Lokeshwar, V.B.7
  • 27
    • 0037059807 scopus 로고    scopus 로고
    • p21-activated kinase links Rac/Cdc42 signaling to merlin
    • Xiao GH, Beeser A, Chernoff J, Testa JR. p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem 2002;277(2):883-886.
    • (2002) J Biol Chem , vol.277 , Issue.2 , pp. 883-886
    • Xiao, G.H.1    Beeser, A.2    Chernoff, J.3    Testa, J.R.4
  • 28
    • 0242298576 scopus 로고    scopus 로고
    • Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pakl
    • Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T. Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pakl. Mol Cell 2003;12(4):841-849.
    • (2003) Mol Cell , vol.12 , Issue.4 , pp. 841-849
    • Kissil, J.L.1    Wilker, E.W.2    Johnson, K.C.3    Eckman, M.S.4    Yaffe, M.B.5    Jacks, T.6
  • 29
    • 1842843307 scopus 로고    scopus 로고
    • Interfering with Ras signaling using membrane-permeable peptides or drugs
    • Maruta H, He H, Nheu T. Interfering with Ras signaling using membrane-permeable peptides or drugs. Methods Mol Biol 2002;189:75-85.
    • (2002) Methods Mol Biol , vol.189 , pp. 75-85
    • Maruta, H.1    He, H.2    Nheu, T.3
  • 30
    • 0032894222 scopus 로고    scopus 로고
    • Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines
    • Putz T, Culig Z, Eder IE, Nessler-Menardi C, Bartsch G, Grunicke H, Uberall F, Klocker H. Epidermal growth factor (EGF) receptor blockade inhibits the action of EGF, insulin-like growth factor I, and a protein kinase A activator on the mitogen-activated protein kinase pathway in prostate cancer cell lines. Cancer Res 1999;59(1):227-233.
    • (1999) Cancer Res , vol.59 , Issue.1 , pp. 227-233
    • Putz, T.1    Culig, Z.2    Eder, I.E.3    Nessler-Menardi, C.4    Bartsch, G.5    Grunicke, H.6    Uberall, F.7    Klocker, H.8
  • 32
    • 8544230666 scopus 로고    scopus 로고
    • Phosphatidylinositol 3′-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells
    • Lee JT Jr, Steelman LS, McCubrey JA. Phosphatidylinositol 3′-kinase activation leads to multidrug resistance protein-1 expression and subsequent chemoresistance in advanced prostate cancer cells. Cancer Res 2004;64(22):8397-8404.
    • (2004) Cancer Res , vol.64 , Issue.22 , pp. 8397-8404
    • Lee Jr, J.T.1    Steelman, L.S.2    McCubrey, J.A.3
  • 33
    • 18144369320 scopus 로고    scopus 로고
    • Activation of Rac1 by phosphatidylinositol 3-kinase in vivo: Role in activation of mitogen-activated protein kinase (MAPK) pathways and retinoic acid-induced neuronal differentiation of SH-SY5Y cells
    • Pan J, Kao YL, Joshi S, Jeetendran S, Dipette D, Singh US. Activation of Rac1 by phosphatidylinositol 3-kinase in vivo: Role in activation of mitogen-activated protein kinase (MAPK) pathways and retinoic acid-induced neuronal differentiation of SH-SY5Y cells. J Neurochem 2005;93(3):571-583.
    • (2005) J Neurochem , vol.93 , Issue.3 , pp. 571-583
    • Pan, J.1    Kao, Y.L.2    Joshi, S.3    Jeetendran, S.4    Dipette, D.5    Singh, U.S.6
  • 34
    • 20444453281 scopus 로고    scopus 로고
    • A role of STAT3 in Rho GTPase-regulated cell migration and proliferation
    • Debidda M, Wang L, Zang H, Poli V, Zheng Y. A role of STAT3 in Rho GTPase-regulated cell migration and proliferation. J Biol Chem 2005;280(17):17275-17285.
    • (2005) J Biol Chem , vol.280 , Issue.17 , pp. 17275-17285
    • Debidda, M.1    Wang, L.2    Zang, H.3    Poli, V.4    Zheng, Y.5
  • 35
    • 33646116540 scopus 로고    scopus 로고
    • Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival
    • Loucks FA, Le SS, Zimmermann AK, Ryan KR, Barth H, Aktories K, Linseman DA. Rho family GTPase inhibition reveals opposing effects of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase and Janus kinase/signal transducer and activator of transcription signaling cascades on neuronal survival. J Neurochem 2006;97(4):957-967.
    • (2006) J Neurochem , vol.97 , Issue.4 , pp. 957-967
    • Loucks, F.A.1    Le, S.S.2    Zimmermann, A.K.3    Ryan, K.R.4    Barth, H.5    Aktories, K.6    Linseman, D.A.7
  • 36
    • 2442664118 scopus 로고    scopus 로고
    • Rational design and characterization of a Rac GTPase-specific small molecule inhibitor
    • Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor. Proc Natl Acad Sci USA 2004;101(20):7618-7623.
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.20 , pp. 7618-7623
    • Gao, Y.1    Dickerson, J.B.2    Guo, F.3    Zheng, J.4    Zheng, Y.5
  • 37
    • 33645457467 scopus 로고    scopus 로고
    • Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells
    • Nakai Y, Zheng Y, MacCollin M, Ratner N. Temporal control of Rac in Schwann cell-axon interaction is disrupted in NF2-mutant schwannoma cells. J Neurosci 2006;26(13):3390-3395.
    • (2006) J Neurosci , vol.26 , Issue.13 , pp. 3390-3395
    • Nakai, Y.1    Zheng, Y.2    MacCollin, M.3    Ratner, N.4
  • 38
    • 25844447107 scopus 로고    scopus 로고
    • Membrane organization and tumorigenesis - The NF2 tumor suppressor, merlin
    • McClatchey AI, Giovannini M. Membrane organization and tumorigenesis - The NF2 tumor suppressor, merlin. Genes Dev 2005;19(19):2265-2277.
    • (2005) Genes Dev , vol.19 , Issue.19 , pp. 2265-2277
    • McClatchey, A.I.1    Giovannini, M.2
  • 39
    • 9144234897 scopus 로고    scopus 로고
    • Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression
    • Rong R, Surace EI, Haipek CA, Gutmann DH, Ye K. Serine 518 phosphorylation modulates merlin intramolecular association and binding to critical effectors important for NF2 growth suppression. Oncogene 2004;23(52):8447-8454.
    • (2004) Oncogene , vol.23 , Issue.52 , pp. 8447-8454
    • Rong, R.1    Surace, E.I.2    Haipek, C.A.3    Gutmann, D.H.4    Ye, K.5
  • 40
    • 0842329800 scopus 로고    scopus 로고
    • Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function
    • Surace EI, Haipek CA, Gutmann DH. Effect of merlin phosphorylation on neurofibromatosis 2 (NF2) gene function. Oncogene 2004;23(2):580-587.
    • (2004) Oncogene , vol.23 , Issue.2 , pp. 580-587
    • Surace, E.I.1    Haipek, C.A.2    Gutmann, D.H.3
  • 41
    • 0037155916 scopus 로고    scopus 로고
    • Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization
    • Kissil JL, Johnson KC, Eckman MS, Jacks T. Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem 2002;277(12):10394-10399.
    • (2002) J Biol Chem , vol.277 , Issue.12 , pp. 10394-10399
    • Kissil, J.L.1    Johnson, K.C.2    Eckman, M.S.3    Jacks, T.4
  • 42
    • 33847002689 scopus 로고    scopus 로고
    • Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin
    • Bai Y, Liu YJ, Wang H, Xu Y, Stamenkovic I, Yu Q. Inhibition of the hyaluronan-CD44 interaction by merlin contributes to the tumor-suppressor activity of merlin. Oncogene 2007;26(6):836-850.
    • (2007) Oncogene , vol.26 , Issue.6 , pp. 836-850
    • Bai, Y.1    Liu, Y.J.2    Wang, H.3    Xu, Y.4    Stamenkovic, I.5    Yu, Q.6
  • 43
    • 33846702026 scopus 로고    scopus 로고
    • Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac
    • Morrison H, Sperka T, Manent J, Giovannini M, Ponta H, Herrlich P. Merlin/neurofibromatosis type 2 suppresses growth by inhibiting the activation of Ras and Rac. Cancer Res 2007;67(2):520-527.
    • (2007) Cancer Res , vol.67 , Issue.2 , pp. 520-527
    • Morrison, H.1    Sperka, T.2    Manent, J.3    Giovannini, M.4    Ponta, H.5    Herrlich, P.6
  • 44
    • 0037227965 scopus 로고    scopus 로고
    • C D44: From adhesion molecules to signalling regulators
    • Ponta H, Sherman L, Herrlich PA. C D44: From adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol 2003;4(1):33-45.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.1 , pp. 33-45
    • Ponta, H.1    Sherman, L.2    Herrlich, P.A.3
  • 46
    • 27544514090 scopus 로고    scopus 로고
    • Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane
    • Okada T, Lopez-Lago M, Giancotti FG. Merlin/NF-2 mediates contact inhibition of growth by suppressing recruitment of Rac to the plasma membrane. J Cell Biol 2005;171(2):361-371.
    • (2005) J Cell Biol , vol.171 , Issue.2 , pp. 361-371
    • Okada, T.1    Lopez-Lago, M.2    Giancotti, F.G.3
  • 49
    • 33746722720 scopus 로고    scopus 로고
    • Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase
    • Jin H, Sperka T, Herrlich P, Morrison H. Tumorigenic transformation by CPI-17 through inhibition of a merlin phosphatase. Nature 2006;442(7102):576- 579.
    • (2006) Nature , vol.442 , Issue.7102 , pp. 576-579
    • Jin, H.1    Sperka, T.2    Herrlich, P.3    Morrison, H.4
  • 50
    • 14844355090 scopus 로고    scopus 로고
    • The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
    • Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG, Jhanwar S, Testa JR. The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol 2005;25(6):2384-2394.
    • (2005) Mol Cell Biol , vol.25 , Issue.6 , pp. 2384-2394
    • Xiao, G.H.1    Gallagher, R.2    Shetler, J.3    Skele, K.4    Altomare, D.A.5    Pestell, R.G.6    Jhanwar, S.7    Testa, J.R.8
  • 51
    • 33749188461 scopus 로고    scopus 로고
    • Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK
    • Poulikakos PI, Xiao GH, Gallagher R, Jablonski S, Jhanwar SC, Testa JR. Re-expression of the tumor suppressor NF2/merlin inhibits invasiveness in mesothelioma cells and negatively regulates FAK. Oncogene 2006;25:5960-5968.
    • (2006) Oncogene , vol.25 , pp. 5960-5968
    • Poulikakos, P.I.1    Xiao, G.H.2    Gallagher, R.3    Jablonski, S.4    Jhanwar, S.C.5    Testa, J.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.