Synthesis of 5″-branched derivatives of cyclic ADP-carbocyclic-ribose, a potent Ca2+-mobilizing agent: The first antagonists modified at the N1-ribose moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3814-3818

  Sakaguchi, Natsumi ^a   Kudoh, Takashi ^a   Tsuzuki, Takayoshi ^a   Murayama, Takashi ^b   Sakurai, Takashi ^b   Matsuda, Akira ^a   Arisawa, Mitsuhiro ^a   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Ca2+ mobilization; cADPR; Nucleotide; Second messenger

Indexed keywords

CYCLIC ADENOSINE DIPHOSPHATE RIBOSE; RIBOSE; ADENINE; ADENOSINE DIPHOSPHATE RIBOSE; CALCIUM; CYCLIC ADP CARBOCYCLIC RIBOSE; CYCLIC ADP-CARBOCYCLIC-RIBOSE; DRUG DERIVATIVE; PHOSPHATE;

ARTICLE; CALCIUM MOBILIZATION; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; NONHUMAN; SEA URCHIN; CALCIUM SIGNALING; CHEMICAL MODEL; CHEMISTRY; DRUG ANTAGONISM; METHODOLOGY; PH; SIGNAL TRANSDUCTION; STEREOISOMERISM;

ADENINE; ADENOSINE DIPHOSPHATE RIBOSE; CALCIUM; CALCIUM SIGNALING; CHEMISTRY, PHARMACEUTICAL; CYCLIC ADP-RIBOSE; DRUG DESIGN; HYDROGEN-ION CONCENTRATION; MODELS, CHEMICAL; PHOSPHATES; RIBOSE; SIGNAL TRANSDUCTION; STEREOISOMERISM;

EID: 44849127953     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.083     Document Type: Article

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