Substitution at the 8-position of 3″-deoxy-cyclic ADP-carbocyclic-ribose, a highly potent Ca2+-mobilizing agent, provides partial agonists1

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 8, 2007, Pages 3032-3040

  Kudoh, Takashi ^a   Murayama, Takashi ^b   Matsuda, Akira ^a   Shuto, Satoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Calcium; Carbocyclic ribose; Cyclic ADP ribose; Partial agonist; Second messenger

Indexed keywords

3'' DEOXY CYCLIC ADENOSINE DIPHOSPHATE CARBOCYCLIC RIBOSE; 8 AMINO 3'' DEOXY CYCLIC ADENOSINE DIPHOSPHATE CARBOCYCLIC RIBOSE; RIBOSE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

ANIMALS; CALCIUM; CYCLIC ADP-RIBOSE; DOSE-RESPONSE RELATIONSHIP, DRUG; INDICATORS AND REAGENTS; OVUM; SEA URCHINS; SPECTROMETRY, MASS, FAST ATOM BOMBARDMENT; SPECTROPHOTOMETRY, ULTRAVIOLET; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947111978     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.02.001     Document Type: Article

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