Evidence for major pleiotropic effects on bone size variation from a principal component analysis of 451 Caucasian families

Acta Pharmacologica Sinica

Volumn 29, Issue 6, 2008, Pages 745-751

  Tan, Li Jun ^a   Liu, Yao Zhong ^d   Xiao, Peng ^c   Yang, Fang ^a   Tang, Zi Hui ^a   Liu, Peng Yuan ^c   Recker, Robert R ^c   Deng, Hong Wen ^a,b,d  

^a HUNAN NORMAL UNIVERSITY   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^d UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Bone size; Principal component; Whole genome linkage scan

Indexed keywords

ADULT; ANATOMICAL VARIATION; ARTICLE; BIVARIATE ANALYSIS; BODY MASS; BONE DEVELOPMENT; BONE SIZE; CAUCASIAN; CHROMOSOME 11; CHROMOSOME 7; CONTROLLED STUDY; FAMILY; FEMALE; FEMUR NECK; GENE FUNCTION; GENE STRUCTURE; GENETIC ANALYSIS; GENETIC CORRELATION; GENETIC LINKAGE; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HIP; HUMAN; HUMAN GENOME; LUMBAR SPINE; MAJOR CLINICAL STUDY; MALE; MICROSATELLITE MARKER; MUSCULOSKELETAL SYSTEM PARAMETERS; PEDIGREE ANALYSIS; PLEIOTROPY; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT LOCUS; SEX LINKAGE; STATISTICAL SIGNIFICANCE; WRIST;

ADULT; BONE AND BONES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE TRAIT LOCI; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; UNITED STATES;

EID: 44849086380     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1111/j.1745-7254.2008.00806.x     Document Type: Article

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