Insight from molecular modeling into different conformation and SAR of natural steroids and unnatural 7-oxa-steroids

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 13, 2008, Pages 3687-3690

  Kang, Fu An ^a   Chen, Xin ^a   Jain, Nareshkumar ^a   Allan, George ^a   Tannenbaum, Pamela ^a   Lundeen, Scott ^a   Sui, Zhihua ^a  

^a Development LLC   (United States)

Author keywords

Mifepristone; Molecular modeling; Oxa steroid; Progesterone receptor antagonist

Indexed keywords

7 OXA STEROID DERIVATIVE; ANTIGESTAGEN; BENZENE DERIVATIVE; CARBON; CARBON DIOXIDE; COMPLEMENT COMPONENT C3; GLUCOCORTICOID RECEPTOR; MEDROXYPROGESTERONE ACETATE; MIFEPRISTONE; OXYGEN; PHENYLALANINE; PROGESTERONE DERIVATIVE; PROGESTERONE RECEPTOR; RIBOSOME RNA; RU 746; STEROID;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEMETHYLATION; DOSE RESPONSE; DRUG CONFORMATION; DRUG HYDROXYLATION; DRUG METABOLISM; DRUG OXIDATION; DRUG STRUCTURE; INCUBATION TIME; LIVER MICROSOME; MOLECULAR MODEL; NONHUMAN; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; QUANTUM MECHANICS; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBON; COMPLEMENT C3; COMPUTER SIMULATION; INHIBITORY CONCENTRATION 50; MIFEPRISTONE; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, PROGESTERONE; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 44749092446     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.05.070     Document Type: Article

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