Successful prevalidation of the slug mucosal irritation test to assess the eye irritation potency of chemicals

Toxicology in Vitro

Volumn 22, Issue 5, 2008, Pages 1285-1296

  Adriaens, E ^a   Bytheway, H ^b   De Wever, B ^c   Eschrich, D ^c   Guest, R ^b   Hansen, E ^d   Vanparys, P ^d   Schoeters, G ^e   Warren, N ^b   Weltens, R ^e   Whittingham, A ^b   Remon, J P ^a  

^a GHENT UNIVERSITY   (Belgium)

^b Safepharm Laboratories Ltd   (United Kingdom)

^c Phenion GmbH   (Germany)

^d JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^e FLEMISH INSTITUTE FOR TECHNOLOGICAL RESEARCH VITO   (Belgium)

Author keywords

Alternative method; Eye irritation; Mucosal irritation test; Prevalidation study

Indexed keywords

2 ETHYLHEXANOL; 2,4,5,6 TETRAAMINOPYRIMIDINE SULFATE; 3 METHOXY 1,2 PROPANEDIOL; ACETIC ACID ETHYL ESTER; ACETONE; AMMONIUM NITRATE; BENZALKONIUM; BORIC ACID; CETYLPYRIDINIUM SALT; CHEMICAL AGENT; CHLORHEXIDINE; CYCLOPENTANE DERIVATIVE; GLYCEROL; HEXANOL; IMIDAZOLE; MACROGOL 400; METHYLCYCLOPENTANE; OCTANOL; OXALATE SODIUM; OXALIC ACID DERIVATIVE; POLYSORBATE 20; POTASSIUM TETRAFLUOROBORATE; PROMETHAZINE; PROPANEDIOL DERIVATIVE; PYRIMIDINE DERIVATIVE; TRITON X 100;

ARTICLE; DILUTION; DISCRIMINANT ANALYSIS; EYE IRRITATION; LABORATORY TEST; MUCUS; NONHUMAN; PROTEIN SECRETION; VALIDATION STUDY;

ANIMAL USE ALTERNATIVES; ANIMALS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EYE; IRRITANTS; L-LACTATE DEHYDROGENASE; MOLLUSCA; MUCUS; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; SKIN; TOXICITY TESTS;

EID: 44749091416     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2008.02.018     Document Type: Article

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