Slug species- and population-specific effects on the end points of the Slug Mucosal Irritation test

Toxicology in Vitro

Volumn 20, Issue 4, 2006, Pages 448-457

  Dhondt, Marijke M M ^a   Adriaens, Els ^a   Pinceel, Jan ^c   Jordaens, Kurt ^c   Backeljau, Thierry ^b,c   Remon, Jean Paul ^a  

^a GHENT UNIVERSITY   (Belgium)

^b ROYAL BELGIAN INSTITUTE OF NATURAL SCIENCES   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

Author keywords

Alternative test; Mucosal irritation; Slugs

Indexed keywords

IRRITANT AGENT;

ARTICLE; COMMUNITY ECOLOGY; CONTROLLED STUDY; EYE INJURY; EYE IRRITATION; METHODOLOGY; MOLLUSC; MUCOSA; NONHUMAN; PREDICTION; SPECIES; TOXICITY TESTING;

ANIMAL POPULATION GROUPS; ANIMAL USE ALTERNATIVES; ANIMALS; ENDPOINT DETERMINATION; EYE DISEASES; IRRITANTS; MOLLUSCA; MUCOUS MEMBRANE; MUCUS; RABBITS; REPRODUCIBILITY OF RESULTS; SPECIES SPECIFICITY; TOXICITY TESTS; XENOBIOTICS;

ARION LUSITANICUS; GASTROPODA; LIMAX FLAVUS; MOLLUSCA;

EID: 33645228306     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2005.09.002     Document Type: Article

References (27)

1. E. Adriaens, and J.P. Remon Gastropods as an evaluation tool for screening the irritating potency of absorption enhancers and drugs Pharmaceutical Research 16 1999 1240 1244
2. E. Adriaens, and J.P. Remon Evaluation of an alternative mucosal irritation test using slugs Toxicology and Applied Pharmacology 182 2002 169 175
3. ® 974P mixtures Journal of Controlled Release 88 2003 393 399
4. E. Adriaens, M.M.M. Dhondt, and J.P. Remon Refinement of the Slug Mucosal Irritation test as an alternative screening test for eye irritation Toxicology in Vitro 19 2005 79 89
5. M. Balls, N. Berg, L.H. Bruner, R.D. Curren, O. de Silva, L.K. Earl, D.J. Esdaile, J.H. Fentem, M. Liebsch, Y. Ohno, M.K. Prinsen, H. Spielmann, and A.P. Worth Eye irritation testing: the way forward. The report and recommendations of ECVAM workshop 34 Alternatives to Laboratory Animals 27 1999 53 77
6. ® 974 P on rabbit nasal mucosa and slug mucosa Journal of Controlled Release 76 2001 81 91
7. J.A. Cooper, R. Saracci, and P. Cole Describing the validity of carcinogen screening tests British Journal of Cancer 39 1979 87 89
8. CPMP, 1997. Replacement of animal studies by in vitro models, CPMP/SWP/728/95. Committee for Proprietary Medicinal Products, London, United Kingdom, 6pp. Available from: 〈http://www.emea.eu.int/pdfs/human/swp/ 072895en.pdf〉. Accessed on 7 January 2005.
9. I. Deyrup-Olsen, and D.L. Luchtel Secretion of mucous granules and other membrane-bound structures: a look beyond exocytosis International Review of Cytology 183 1998 95 141
10. DGKC (Deutsche Gesellschaft für Klinische Chemie) Standardisierung von methoden zur bestimmung von enzymaktivitäten in biologischen flüssigkeiten Zeitschrift für Klinische Chemie und Klinische Biochemie 10 1972 182
11. M.M.M. Dhondt, E. Adriaens, and J.P. Remon The evaluation of the local tolerance of vaginal formulations, with or without nonoxynol-9, using the Slug Mucosal Irritation test Sexually Transmitted Diseases 31 2004 229 235
12. M.M.M. Dhondt, E. Adriaens, J. Van Roey, and J.P. Remon The evaluation of the local tolerance of vaginal formulations containing dapivirine using the Slug Mucosal Irritation test and the rabbit vaginal irritation test European Journal of Pharmaceutics and Biopharmaceutics 60 2005 419 425
13. EC Council Directive 75/318/EEC of 20 May 1975 on the approximation of the laws of Member States relating to analytical, pharmacotoxicological and clinical standards and protocols in respect of the testing of medicinal products Official Journal of the European Communities L 147 1975 13 40
14. EC Council Directive 86/609/EEC of 24 November 1986 on the approximation of laws, regulations and administrative provisions of the Member States regarding the protection of animals used for experimental and other scientific purposes Official Journal of the European Communities L 358 1986 1 28
15. EC, 1990. Guideline 3BS12a non-clinical local tolerance testing of medicinal products. In: The rules governing medicinal products in the European Union, Eudralex, Guidelines, pp. 107-116.
16. EC, 2001. Annex VI General classification and labelling requirements for dangerous substances and preparations, ocular lesions. In: Commission Directive 2001/59/EEC of 6 August 2001 adapting to technical progress for the 28th time Council Directive 67/548/EEC on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Official Journal of the European Communities L 225, 278-279.
17. EC, 2004. Annex V Testing methods, B5 Acute toxicity: eye irritation/corrosion. In: Commission Directive 2004/73/EC of 29 April 2004 adapting to technical progress for the 29th time Council Directive 67/548/EEC on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Official Journal of the European Communities L 152, 201-212.
18. ECETOC, 1998. Eye irritation reference chemicals data bank. European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, Belgium, 236pp.
19. J.L. Fleiss Statistical Methods for Rates and Proportions 1981 John Wiley and Sons New York, USA 321pp
20. L. Gilleron, S. Coecke, M. Sysmans, E. Hansen, S. Van Oproy, D. Marzin, H. Van Cauteren, and Ph. Vanparys Evaluation of a modified HET-CAM assay as a screening test for eye irritancy Toxicology in Vitro 10 1996 431 446
21. L. Gilleron, S. Coecke, M. Sysmans, E. Hansen, S. Van Oproy, D. Marzin, H. Van Cauteren, and Ph. Vanparys Evaluation of the HET-CAM-TSA method as an alternative to the Draize eye irritation test Toxicology in Vitro 11 1997 641 644
22. OECD OECD Guidelines for the Testing of Chemicals 2004 Organisation for Economic Co-operation and Development Paris, France
23. M.K. Prinsen An evaluation of the OECD proposal for the harmonised classification of eye irritants and corrosives Alternatives to Laboratory Animals 27 1999 72 77
24. A. South Terrestrial Slugs: Biology, Ecology and Control 1992 Chapman & Hall London, United Kingdom 427pp
25. Van Goethem, F., Adriaens, E., Alépée, N., Straube, F., De Wever, B., Cappadoro, M., Catoire, S., Hansen, E., Wolf, A., Vanparys, Ph. (in press). Prevalidation of a new in vitro reconstituted human cornea model to assess the eye irritating potential of chemicals. Toxicology in Vitro doi:10.1016/j.tiv.2005.05.002 .
26. Ph. Vanparys, G. Deknudt, M. Sysmans, G. Teuns, W. Coussement, and H. Van Cauteren Evaluation of the bovine corneal opacity permeability assay as an in vitro alternative to the Draize eye irritation test Toxicology in Vitro 7 1993 471 476
27. C.M. Wade, P.B. Mordan, and B. Clarke A phylogeny of the land snails (Gastropoda: Pulmonata) Proceedings of the Royal Society of London B268 2001 413 422