A rapid and sensitive LC-MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies

Journal of Pharmaceutical and Biomedical Analysis

Volumn 47, Issue 4-5, 2008, Pages 985-989

  Wang, Jiang ^a   Jiang, Yao ^a   Wang, Yingwu ^a   Tang, Yunbiao ^b   Teng, Guosheng ^a   Fawcett, J Paul ^c   Kong, Jian ^a   Gu, Jingkai ^a  

^a JILIN UNIVERSITY   (China)

^b GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

LC MS MS; Pharmacokinetics; Plasma; Rat; Yonkenafil

Indexed keywords

AMMONIUM ACETATE; BUFFER; DIAZEPAM; METHANOL; PHOSPHODIESTERASE V INHIBITOR; YONKENAFIL;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DETERMINATION; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LINEAR SYSTEM; LIQUID CHROMATOGRAPHY; LIQUID LIQUID EXTRACTION; MALE; MASS SPECTROMETER; NONHUMAN; PLASMA; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RAT; SEPARATION TECHNIQUE; STANDARD; TANDEM MASS SPECTROMETRY;

ACETATES; ADMINISTRATION, ORAL; ADMINISTRATION, SUBLINGUAL; ANIMALS; BIOLOGICAL AVAILABILITY; BUFFERS; CHROMATOGRAPHY, LIQUID; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 5; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; FASTING; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; MALE; METHANOL; MOLECULAR STRUCTURE; PHOSPHODIESTERASE INHIBITORS; QUALITY CONTROL; RANDOM ALLOCATION; RATS; RATS, WISTAR; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TIME FACTORS;

EID: 44749089098     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2008.04.004     Document Type: Article

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