Drug resistance in epilepsy: Human epilepsy

Novartis Foundation Symposium

Volumn 243, Issue , 2002, Pages 167-179

  Sisodiya, S M ^a   Lin, W R ^a   Harding, B N ^b   Squier, M V ^c   Thom, M ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTICONVULSIVE AGENT; GLYCOPROTEIN P; MONOCLONAL ANTIBODY; MULTIDRUG RESISTANCE PROTEIN; NERVE PROTEIN; TUMOR PROTEIN;

ARTICLE; BLOOD BRAIN BARRIER; BRAIN CORTEX; BRAIN LEVEL; BRAIN TUMOR; CHEMISTRY; CONGENITAL MALFORMATION; DRUG RESISTANCE; EPILEPSY; FOCAL EPILEPSY; GLIA; HIPPOCAMPUS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; METABOLISM; MULTIDRUG RESISTANCE; NEUROECTODERM TUMOR; PATHOLOGY; PHYSIOLOGY; SCLEROSIS;

ANTIBODIES, MONOCLONAL; ANTICONVULSANTS; BLOOD-BRAIN BARRIER; BRAIN CHEMISTRY; BRAIN NEOPLASMS; CEREBRAL CORTEX; DRUG RESISTANCE; DRUG RESISTANCE, MULTIPLE; EPILEPSIES, PARTIAL; EPILEPSY; HIPPOCAMPUS; HUMANS; IMMUNOHISTOCHEMISTRY; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; NEOPLASM PROTEINS; NERVE TISSUE PROTEINS; NEUROECTODERMAL TUMORS, PRIMITIVE; NEUROGLIA; P-GLYCOPROTEIN; SCLEROSIS;

EID: 0036369039     PISSN: None     EISSN: None     Source Type: Book Series    
DOI: None     Document Type: Article

References (20)

1. Adkison KD, Artru AA, Powers KM, Nochlin D, Shen DD 1995 Role of choroid plexus epithelium in the removal of valproic acid from the central nervous system. Epilepsy Res 20:185-192
2. Beck WT, Grogan TM, Willman CL et al 1996 Methods to detect P-glycoprotein-associated multidrug resistance in patients' tumors: consensus recommendations. Cancer Res 56:3010-3020
3. Hipfner DR, Deeley RG, Cole SP 1999b Structural, mechanistic and clinical aspects of MRP1. Biochim Biophys Acta 1461:359-376
4. Hipfner DR, Gao M, Scheffer G, Scheper RJ, Deeley RG, Cole SP 1998 Epitope mapping of monoclonal antibodies specific for the 190-kDa multidrug resistance protein (MRP). Br J Cancer 78:1134-1140
5. Hipfner DR, Mao Q, Qiu W et al 1999a Monoclonal antibodies that inhibit the transport function of the 190-kDa multidrug resistance protein, MRP. Localization of their epitopes to the nucleotide-binding domains of the protein. J Biol Chem 274:15420-15426
6. Lazarowski A, Sevlever G, Taratuto A, Massaro M, Rabinowicz A 1999 Tuberous sclerosis associated with MDR1 gene expression and drug-resistant epilepsy. Pediatr Neurol 21:731-734
7. Levy RH, Mattson RH, Meldrum BS 1995 Antiepileptic drugs. Raven Press, New York
8. Peters A, Palay SL, de Webster H F 1991 The fine structure of the nervous system. Oxford University Press, Oxford
9. Rao VV, Anthony DC, Piwnica-Worms D 1994 MDR1 gene-specific monoclonal antibody C494 cross-reacts with pyruvate carboxylase. Cancer Res 54:1536-1541
10. Rao VV, Dahlheimer JL, Bardgett ME et al 1999 Choroid plexus epithelial expression of MDR1 P glycoprotein and multidrug resistance-associated protein contribute to the blood-cerebrospinal-fluid drug-permeability barrier. Proc Natl Acad Sci USA 96:3900-3905
11. Sander JW 1993 Some aspects of prognosis in the epilepsies: a review. Epilepsia 34:1007-1016
12. Scheffer GL, Kool M, Heijn M et al 2000 Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies. Cancer Res 60:5269-5277
13. Schinkel AH 1999 P-Glycoprotein, a gatekeeper in the blood-brain barrier. Adv Drug Deliv Rev 36:179-194
14. Schuetz EG, Beck WT, Schuetz JD 1996 Modulators and substrates of P-glycoprotein and cytochrome P4503A coordinately up-regulate these proteins in human colon carcinoma cells. Mol Pharmacol 49:311-318
15. Sisodiya SM, Heffernan J, Squier MV 1999 Over-expression of P-glycoprotein in malformations of cortical development. Neuroreport 10:3437-3441
16. Sisodiya SM, Lin WR, Squier MV, Thom M 2001 Multidrug-resistance protein 1 in focal cortical dysplasia. Lancet 357:42-43
17. Tan B, Piwnica-Worms D, Ratner L 2000 Multidrug resistance transporters and modulation. Curr Opin Oncol 12:450-458
18. Tishler DM, Weinberg KI, Hinton DR, Barbaro N, Annett GM, Raffel C 1995 MDR1 gene expression in brain of patients with medically intractable epilepsy. Epilepsia 36:1-6
19. Vilaboa NE, Galán A, Troyano A, de Blas E, Aller P 2000 Regulation of multidrug resistance 1 (MDR1)/P-glycoprotein gene expression and activity by heat-shock transcription factor 1 (HSF1). J Biol Chem 275:24970-24976
20. Wijnholds J, deLange EC, Scheffer GL et al 2000 Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier. J Clin Invest 105:279-285