Binding and activation of human and mouse complement by Cryptosporidium parvum (Apicomplexa) and susceptibility of C1q- and MBL-deficient mice to infection

Molecular Immunology

Volumn 45, Issue 12, 2008, Pages 3392-3400

  Petry, Franz ^a   Jakobi, Vera ^a   Wagner, Swen ^a   Tessema, Tesfaye Sisay ^a   Thiel, Steffen ^b   Loos, Michael ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

Activation; Binding; C1q; Complement; Cryptosporidium; Infection; MBL

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; CD40 ANTIGEN; CD83 ANTIGEN; GAMMA INTERFERON; INTERFERON CONSENSUS SEQUENCE BINDING PROTEIN; INTERFERON REGULATORY FACTOR 1; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 12P40; LIPOPOLYSACCHARIDE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; PROTEASOME; PROTEINASE INHIBITOR; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; VANADIUM DERIVATIVE;

AMASTIGOTE; ANIMAL CELL; ANIMAL MODEL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CELL FUNCTION; CELL MATURATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; DOWN REGULATION; FEMALE; IMMUNOREGULATION; INTRACELLULAR SPACE; LEISHMANIA; LEISHMANIASIS; LYMPHOCYTE ACTIVATION; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMASTIGOTE; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TH1 CELL;

ANIMALS; CATTLE; COMPLEMENT ACTIVATION; COMPLEMENT C1Q; COMPLEMENT C3B; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DISEASE SUSCEPTIBILITY; GENE EXPRESSION REGULATION; HUMANS; MANNOSE-BINDING LECTIN; MICE; MICE, INBRED C57BL; OOCYSTS; PROTOZOAN PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SODIUM CHLORIDE; TEMPERATURE;

ANIMALIA; APICOMPLEXA; CRYPTOSPORIDIUM; CRYPTOSPORIDIUM PARVUM; MUS; PROTOZOA;

EID: 44749085978     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2008.04.010     Document Type: Article

References (39)

1. Blanshard C., Jackson A.M., Shanson D.C., Francis N., and Gazzard B.G. Cryptosporidiosis in HIV-seropositive patients. Q. J. Med. 85 (1992) 813-823
2. Botto M., Dell'Agnola C., Bygrave A.E., Thompson E.M., Cook H.T., Petry F., Loos M., Pandolfi P.P., and Walport M.J. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat. Genet. 19 (1998) 56-59
3. Chen W., Harp J.A., and Harmsen A.G. Requirements for CD4+ cells and gamma interferon in resolution of established Cryptosporidium parvum infection in mice. Infect. Immun. 61 (1993) 3928-3932
4. Dumestre-Perard C., Ponard D., Arlaud G.J., Monnier N., Sim R.B., and Colomb M.G. Evaluation and clinical interest of mannan binding lectin function in human plasma. Mol. Immunol. 39 (2002) 465-473
5. Ehigiator H.N., McNair N., and Mead J.R. IL-12 knockout C57BL/6 mice are protected from re-infection with Cryptosporidium parvum after challenge. J. Eukaryot. Microbiol. 50 (2003) 539-541
6. Entwistle R.A., and Furcht L.T. C1q component of complement binds to fibrinogen and fibrin. Biochemistry 27 (1988) 507-512
7. Hansen S., Thiel S., Willis A., Holmskov U., and Jensenius J.C. Purification and characterization of two mannan-binding lectins from mouse serum. J. Immunol. 164 (2000) 2610-2618
8. Heine J., Moon H.W., and Woodmansee D.B. Persistent Cryptosporidium infection in congenitally athymic (nude) mice. Infect. Immun. 43 (1984) 856-859
9. Jakobi V., and Petry F. Differential expression of Cryptosporidium parvum genes encoding sporozoite surface antigens in infected HCT-8 host cells. Microbes Infect. 8 (2006) 2186-2194
10. Jakobi V., and Petry F. Humoral immune response in interleukin-12 and interferon-g deficient mice after infection with Cryptosporidium parvum. Parasite Immunol. 30 (2008) 151-161
11. Kaul M., and Loos M. Dissection of C1q capability of interacting with IgG. Time-dependent formation of a tight and only partly reversible association. J. Biol. Chem. 272 (1997) 33234-33244
12. Kelly P., Jack D.L., Naeem A., Mandanda B., Pollok R.C., Klein N.J., Turner M.W., and Farthing M.J. Mannose-binding lectin is a component of innate mucosal defense against Cryptosporidium parvum in AIDS. Gastroenterology 119 (2000) 1236-1242
13. Kirkpatrick B.D., Huston C.D., Wagner D., Noel F., Rouzier P., Pape J.W., Bois G., Larsson C.J., Alston W.K., Tenney K., Powden C., O'Neill J.P., and Sears C.L. Serum mannose-binding lectin deficiency is associated with cryptosporidiosis in young Haitian children. Clin. Infect. Dis. 43 (2006) 289-294
14. Lacroix-Lamande S., Mancassola R., Naciri M., and Laurent F. Role of gamma interferon in chemokine expression in the ileum of mice and in a murine intestinal epithelial cell line after Cryptosporidium parvum infection. Infect. Immun. 70 (2002) 2090-2099
15. Leav B.A., Yoshida M., Rogers K., Cohen S., Godiwala N., Blumberg R.S., and Ward H. An early intestinal mucosal source of gamma interferon is associated with resistance to and control of Cryptosporidium parvum infection in mice. Infect. Immun. 73 (2005) 8425-8428
16. Loos M., and Clas F. Antibody-independent killing of gram-negative bacteria via the classical pathway of complement. Immunol. Lett. 14 (1987) 203-208
17. Magram J., Sfarra J., Connaughton S., Faherty D., Warrier R., Carvajal D., Wu C.Y., Stewart C., Sarmiento U., and Gately M.K. IL-12-Deficient mice are defective but not devoid of type 1 cytokine responses. Ann. N.Y. Acad. Sci. 795 (1996) 60-70
18. McDonald S.A.C., O'Grady J.E., Bajaj-Elliott M., Notley C.A., Alexander J., Brombacher F., and McDonald V. Protection against the early acute phase of Cryptosporidium parvum infection conferred by interleukin-4-induced expression of T helper 1 cytokines. J. Infect. Dis. 190 (2004) 1019-1025
19. McDonald V. Host cell-mediated responses to infection with Cryptosporidium. Parasite Immunol. 22 (2000) 597-604
20. Nesterenko M.V., and Upton S.J. A rapid microfuge procedure for the purification of Cryptosporidium sporozoites. J. Microbiol. Meth. 25 (1996) 87-89
21. Petry F. Epidemiological study of Cryptosporidium parvum antibodies in sera of persons from Germany. Infection 26 (1998) 7-10
22. Petry F., and Harris J.R. Ultrastructure, fractionation and biochemical analysis of Cryptosporidium parvum sporozoites. Int. J. Parasitol. 29 (1999) 1249-1260
23. Petry F., Hauptmann G., Goetz J., Grosshans E., and Loos M. Molecular basis of a new type of C1q-deficiency associated with a non-functional low molecular weight (LMW) C1q - parallels and differences to other known genetic C1q-defects. Immunopharmacology 38 (1997) 189-202
24. Petry F., and Loos M. Bacteria and complement. In: Volanakis J.E., and Frank M.M. (Eds). The Human Complement System in Health and Disease (1998), Marcel Dekker Inc., New York 375-392
25. Petry F., Reid K.B.M., and Loos M. Isolation, sequence analysis and characterization of cDNA clones coding for the C-chain of mouse C1q - sequence similarity of complement subcomponent C1q, collagen type VIII and type X and precerebellin. Eur. J. Biochem. 209 (1992) 129-134
26. Petry F., Reid K.B.M., and Loos M. Gene expression of the A-and B-chain of mouse C1q in different tissues and the characterization of the recombinant A-chain. J. Immunol. 1470 (1991) 3988-3993
27. Pollok R.C., Farthing M.J., Bajaj-Elliott M., Sanderson I.R., and McDonald V. Interferon gamma induces enterocyte resistance against infection by the intracellular pathogen Cryptosporidium parvum. Gastroenterology 120 (2001) 99-107
28. Ringelmann R., Opferkuch W., Rollinghoff M., and Loos M. Measurement of complement with a microliter method. Z. Med. Mikrobiol. Immunol. 154 (1969) 329-343
29. Shi L., Takahashi K., Dundee J., Shahroor-Karni S., Thiel S., Jensenius J.C., Gad F., Hamblin M.R., Sastry K.N., and Ezekowitz R.A. Mannose-binding lectin-deficient mice are susceptible to infection with Staphylococcus aureus. J. Exp. Med. 199 (2004) 1379-1390
30. Stemmer F., and Loos M. Purification and characterisation of human, guinea pig and mouse C1q by fast protein liquid chromatography (FPLC). J. Immunol. Meth. 74 (1984) 9-16
31. Taylor P.R., Nash J.T., Theodoridis E., Bygrave A.E., Walport M.J., and Botto M. A targeted disruption of the murine complement factor B gene resulting in loss of expression of three genes in close proximity, factor B, C2, and D17H6S45. J. Biol. Chem. 273 (1998) 1699-1704
32. Taylor P.R., Seixas E., Walport M.J., Langhorne J., and Botto M. Complement contributes to protective immunity against reinfection by Plasmodium chabaudi chabaudi parasites. Infect. Immun. 69 (2001) 3853-3859
33. Thiel S. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol. Immunol. 44 (2007) 3875-3888
34. Turner M.W. The role of mannose-binding lectin in health and disease. Mol. Immunol. 40 (2003) 423-429
35. Uemura K., Saka M., Nakagawa T., Kawasaki N., Thiel S., Jensenius J.C., and Kawasaki T. L-MBP is expressed in epithelial cells of mouse small intestine. J. Immunol. 169 (2002) 6945-6950
36. Uwatoko S., and Mannik M. The location of binding sites on C1q for DNA. J. Immunol. 144 (1990) 3484-3488
37. Wagner S., Lynch N.J., Walter W., Schwaeble W.J., and Loos M. Differential expression of the murine mannose-binding lectins A and C in lymphoid and nonlymphoid organs and tissues. J. Immunol. 170 (2003) 1462-1465
38. Wang H.C., Dann S.M., Okhuysen P.C., Lewis D.E., Chappell C.L., Adler D.G., and White Jr. A.C. High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity. Infect. Immun. 75 (2007) 481-487
39. Zaalouk T.K., Bajaj-Elliott M., George J.T., and McDonald V. Differential regulation of beta-defensin gene expression during Cryptosporidium parvum infection. Infect. Immun. 72 (2004) 2772-2779