High levels of CXCL10 are produced by intestinal epithelial cells in AIDS patients with active cryptosporidiosis but not after reconstitution of immunity

Infection and Immunity

Volumn 75, Issue 1, 2007, Pages 481-487

  Wang, Heuy Ching ^a   Dann, Sara M ^a   Okhuysen, Pablo C ^b   Lewis, Dorothy E ^a   Chappell, Cynthia L ^b   Adler, Douglas G ^b,c   White Jr , A Clinton ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS SCHOOL OF PUBLIC HEALTH   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE; CHEMOKINE RECEPTOR CXCR3; CYTOKINE; EOTAXIN; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GRANULOCYTE COLONY STIMULATING FACTOR; INTERLEUKIN 10; INTERLEUKIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AIDS PATIENT; ARTICLE; CELL LYSATE; CLINICAL ARTICLE; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM; CYTOKINE PRODUCTION; EFFECTOR CELL; FECES ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNITY; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; INFLAMMATORY CELL; INTESTINE EPITHELIUM; JEJUNUM BIOPSY; MALE; OOCYST; PARASITE IMMUNITY; PRIORITY JOURNAL;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; ANTI-RETROVIRAL AGENTS; ANTIPARASITIC AGENTS; CHEMOKINES; CHEMOKINES, CXC; CRYPTOSPORIDIOSIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; INTESTINAL MUCOSA; MALE;

EID: 33845978787     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01237-06     Document Type: Article

References (24)

1. Alcantara, C. S., C. H. Yang, T. S. Steiner, L. J. Barrett, A. A. Lima, C. L. Chappell, P. C. Okhuysen, A. C. White, Jr., and R. L. Guerrant. 2003. Interleukin-8, tumor necrosis factor-alpha, and lactoferrin in immunocompetent hosts with experimental and Brazilian children with acquired cryptosporidiosis. Am. J. Trop. Med. Hyg. 68:325-328.
2. Deng, M., C. A. Lancto, and M. S. Abrahamsen. 2004. Cryptosporidium parvum regulation of human epithelial cell gene expression. Int. J. Parasitol. 34:73-82.
3. Dwinell, M. B., N. Lugering, L. Eckmann, and M. F. Kagnoff. 2001. Regulated production of interferon-inducible T-cell chemoattractants by human intestinal epithelial cells. Gastroenterology 120:49-59.
4. Genta, R. M., C. L. Chappell, A. C. White, Jr., K. T. Kimball, and R. W. Goodgame. 1993. Duodenal morphology and intensity of infection in AIDS-related intestinal cryptosporidiosis. Gastroenterology 105:1769- 1775.
5. + T-cell restoration and enhanced gene expression regulating mucosal repair and regeneration. J. Virol. 79:2709-2719.
6. Goodgame, R. W., R. M. Genta, A. C. White, and C. L. Chappell. 1993. Intensity of infection in AIDS-associated cryptosporidiosis. J. Infect. Dis. 167:704-709.
7. Goodgame, R. W., K. Kimball, C. N. Ou, A. C. White, Jr., R. M. Genta, C. H. Lifschitz, and C. L. Chappell. 1995. Intestinal function and injury in acquired immunodeficiency syndrome-related cryptosporidiosis. Gastroenterology 108:1075-1082.
8. Haase, A. T. 2005. Perils at mucosal front lines for HIV and SIV and their hosts. Nat. Rev. Immunol. 5:783-792.
9. Kirkpatrick, B. D., M. M. Daniels, S. S. Jean, J. W. Pape, C. Karp, B. Littenberg, D. W. Fitzgerald, H. M. Lederman, J. P. Nataro, and C. L. Sears. 2002. Cryptosporidiosis stimulates an inflammatory intestinal response in malnourished Haitian children. J. Infect. Dis. 186:94-101.
10. Lacroix-Lamande, S., R. Mancassola, M. Naciri, and F. Laurent. 2002. Role of gamma interferon in chemokine expression in the ileum of mice and in a murine intestinal epithelial cell line after Cryptosporidium parvum infection. Infect. Immun. 70:2090-2099.
11. Lane, B. R., S. R. King, P. J. Bock, R. M. Strieter, M. J. Coffey, and D. M. Markovitz. 2003. The C-X-C chemokine IP-10 stimulates HIV-1 replication. Virology 307:122-134.
12. Laurent, F., L. Eckmann, T. C. Savidge, G. Morgan, C. Theodos, M. Naciri, and M. F. Kagnoff. 1997. Cryptosporidium parvum infection of human intestinal epithelial cells induces the polarized secretion of C-X-C chemokines. Infect. Immun. 65:5067-5073.
13. Loetscher, P., A. Pellegrino, J. H. Gong, I. Mattioli, M. Loetscher, G. Bardi, M. Baggiolini, and I. Clark-Lewis. 2001. The ligands of CXC chemokine receptor 3, I-TAC, Mig, and IP-10 are natural antagonists for CCR3. J. Biol. Chem. 276:2985-2991.
14. Lumadue, J. A., Y. C. Manabe, R. D. Moore, P. C. Belitsos, C. L. Sears, and D. P. Clark. 1998. A clinicopathologic analysis of AIDS-related cryptosporidiosis. AIDS 12:2459-2466.
15. Maillot, C., G. Gargala, A. Delaunay, P. Ducrotte, P. Brasseur, J. J. Ballet, and L. Favennec. 2000. Cryptosporidium parvum infection stimulates the secretion of TGF-beta, IL-8 and RANTES by Caco-2 cell line. Parasitol. Res. 86:947-949.
16. Manabe, Y. C., D. P. Clark, R. D. Moore, J. A. Lumadue, H. R. Dahlman, P. C. Belitsos, R. E. Chaisson, and C. L. Sears. 1998. Cryptosporidiosis in patients with AIDS: correlates of disease and survival. Clin. Infect. Dis. 27:535-542.
17. Okhuysen, P. C., P. Robinson, M. T. Nguyen, E. C. Nannini, D. E. Lewis, A. Janecki, C. L. Chappell, and A. C. White, Jr. 2001. Jejunal cytokine response in AIDS patients with chronic cryptosporidiosis and during immune reconstitution. AIDS 15:802-804.
18. Papadakis, K. A., J. Prehn, D. Zhu, C. Landers, J. Gaiennie, P. R. Fleshner, and S. R. Targan. 2004. Expression and regulation of the chemokine receptor CXCR3 on lymphocytes from normal and inflammatory bowel disease mucosa. Inflamm. Bowel Dis. 10:778-788.
19. Schmidt, W., U. Wahnschaffe, M. Schafer, T. Zippel, M. Arvand, A. Meyerhans, E. O. Reichen, and R. Ullrich. 2001. Rapid increase of mucosal CD4 T cells followed by clearance of intestinal cryptosporidiosis in an AIDS patient receiving highly active antiretroviral therapy. Gasteroenterology 120: 984-987.
20. Seydel, K. B., T. Zhang, G. A. Champion, C. Fichtenbaum, P. E. Swanson, S. Tzipori, J. K. Griffiths, and S. L. Stanley, Jr. 1998. Cryptosporidium parvum infection of human intestinal xenografts in SCID mice induces production of human tumor necrosis factor alpha and interleukin-8. Infect. Immun. 66: 2379-2382.
21. Shibahara, T., J. N. Wilcox, T. Couse, and J. L. Madara. 2001. Characterization of epithelial chemoattractants for human intestinal intraepithelial lymphocytes. Gastroenterology 120:60-70.
22. White, A. C., P. Robinson, P. C. Okhuysen, D. E. Lewis, I. Shahab, S. Lahoti, H. L. DuPont, and C. L. Chappell. 2000. Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion. J. Infect. Dis. 181:701-709.
23. White, A. C., Jr. 2005. Cryptosporidiosis (Cryptosporidium hominis, Cryptosporidium parvum, other species), p. 3215-3228. In G. L. Mandell, J. E. Bennett, and R. Dolin (ed.), Principles and practice of infectious diseases, 6th ed. Elsevier Churchill Livingstone, Philadelphia, PA.
24. Yamamoto, J., Y. Adachi, Y. Onoue, Y. S. Adachi, Y. Okabe, T. Itazawa, M. Toyoda, T. Seki, M. Morohashi, K. Matsushima, and T. Miyawaki. 2000. Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4+ T cells. J. Leukoc. Biol. 68: 568-574.