Epigenetic mechanisms silence a disintegrin and metalloprotease 33 expression in bronchial epithelial cells

Journal of Allergy and Clinical Immunology

Volumn 121, Issue 6, 2008, Pages

  Yang, Youwen ^a   Haitchi, Hans Michael ^a   Cakebread, Julie ^a   Sammut, David ^a   Harvey, Anna ^a   Powell, Robert M ^a   Holloway, John W ^a   Howarth, Peter ^a   Holgate, Stephen T ^a   Davies, Donna E ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

ADAM33; CpG island; epithelial mesenchymal transition; expression; methylation; Promoter

Indexed keywords

BISULFITE; DEOXYCYTIDINE; DISINTEGRIN; LUCIFERASE; METALLOPROTEINASE; METALLOPROTEINASE ADAM 33; TRANSFORMING GROWTH FACTOR BETA1;

ADULT; ARTICLE; ASTHMA; BIOINFORMATICS; BRONCHUS BIOPSY; BRONCHUS MUCOSA; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA METHYLATION; DNA SEQUENCE; EPIGENETICS; FEMALE; FIBROBLAST; GENOME; HUMAN; HUMAN TISSUE; MALE; MESENCHYME CELL; METHODOLOGY; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION REGULATION;

EID: 44649199135     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2008.02.031     Document Type: Article

References (37)

1. Van Eerdewegh P., Little R.D., Dupuis J., Del Mastro R.G., Falls K., Simon J., et al. Association of the ADAM-33 gene with asthma and bronchial hyper-responsiveness. Nature 418 (2002) 426-430
2. De Sanctis G.T., Merchant M., Beier D.R., Dredge R.D., Grobholz J.K., Martin T.R., et al. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet 11 (1995) 150-154
3. Simpson A., Maniatis N., Jury F., Cakebread J.A., Lowe L.A., Holgate S.T., et al. Polymorphisms in a disintegrin and metalloprotease 33 (ADAM33) predict impaired early-life lung function. Am J Respir Crit Care Med 172 (2005) 55-60
4. van Diemen C.C., Postma D.S., Vonk J.M., Bruinenberg M., Schouten J.P., and Boezen H.M. A Disintegrin A Metalloprotease 33 polymorphisms and lung function decline in the general population. Am J Respir Crit Care Med 172 (2005) 329-333
5. Haitchi H.M., Powell R.M., Shaw T.J., Howarth P.H., Wilson S.J., Wilson D.I., et al. ADAM33 expression in asthmatic airways and human embryonic lungs. Am J Respir Crit Care Med 171 (2005) 958-965
6. Blobel C.P. Remarkable roles of proteolysis on and beyond the cell surface. Curr Opin Cell Biol 12 (2000) 606-612
7. Powell R.M., Wicks J., Holloway J.W., Holgate S.T., and Davies D.E. The splicing and fate of ADAM33 transcripts in primary human airways fibroblasts. Am J Respir Cell Mol Biol 31 (2004) 13-21
8. Lee J.Y., Park S.W., Chang H.K., Kim H.Y., Rhim T., Lee J.H., et al. A disintegrin and metalloproteinase 33 protein in patients with asthma: relevance to airflow limitation. Am J Respir Crit Care Med 173 (2006) 729-735
9. Foley S.C., Mogas A.K., Olivenstein R., Fiset P.O., Chakir J., Bourbeau J., et al. Increased expression of ADAM33 and ADAM8 with disease progression in asthma. J Allergy Clin Immunol 119 (2007) 863-871
10. Razin A., and Kantor B. DNA methylation in epigenetic control of gene expression. Prog Mol Subcell Biol 38 (2005) 151-167
11. Dunn J.R., Reed J.E., du Plessis D.G., Shaw E.J., Reeves P., Gee A.L., et al. Expression of ADAMTS-8, a secreted protease with antiangiogenic properties, is downregulated in brain tumours. Br J Cancer 94 (2006) 1186-1193
12. Roach H.I., Yamada N., Cheung K.S., Tilley S., Clarke N.M., Oreffo R.O., et al. Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 52 (2005) 3110-3124
13. Willis B.C., duBois R.M., and Borok Z. Epithelial origin of myofibroblasts during fibrosis in the lung. Proc Am Thorac Soc 3 (2006) 377-382
14. Hurd S.Z. Workshop summary and guidelines: investigative use of bronchoscopy, lavage, and bronchial biopsies in asthma and other airway diseases. J Allergy Clin Immunol 88 (1991) 808-814
15. Clark S.J., Harrison J., Paul C.L., and Frommer M. High sensitivity mapping of methylated cytosines. Nucleic Acids Res 22 (1994) 2990-2997
16. Umland S.P., Garlisi C.G., Shah H., Wan Y., Zou J., Devito K.E., et al. Human ADAM33 mRNA expression profile and post-transcriptional regulation. Am J Respir Cell Mol Biol 29 (2003) 571-582
17. Bird A. The essentials of DNA methylation. Cell 70 (1992) 5-8
18. Frommer M., McDonald L.E., Millar D.S., Collis C.M., Watt F., Grigg G.W., et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci U S A 89 (1992) 1827-1831
19. Ferguson A.T., Evron E., Umbricht C.B., Pandita T.K., Chan T.A., Hermeking H., et al. High frequency of hypermethylation at the 14-3-3 sigma locus leads to gene silencing in breast cancer. Proc Natl Acad Sci U S A 97 (2000) 6049-6054
20. Ghoshal K., Datta J., Majumder S., Bai S., Kutay H., Motiwala T., et al. 5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal. Mol Cell Biol 25 (2005) 4727-4741
21. Kasai H., Allen J.T., Mason R.M., Kamimura T., and Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 6 (2005) 56
22. Gardiner-Garden M., and Frommer M. CpG islands in vertebrate genomes. J Mol Biol 196 (1987) 261-282
23. Takai D., and Jones P.A. Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A 99 (2002) 3740-3745
24. Ioshikhes I.P., and Zhang M.Q. Large-scale human promoter mapping using CpG islands. Nat Genet 26 (2000) 61-63
25. Larsen F., Gundersen G., Lopez R., and Prydz H. CpG islands as gene markers in the human genome. Genomics 13 (1992) 1095-1107
26. Roder K., Latasa M.J., and Sul H.S. Silencing of the mouse H-rev107 gene encoding a class II tumor suppressor by CpG methylation. J Biol Chem 277 (2002) 30543-30550
27. Holliday R., and Pugh J.E. DNA modification mechanisms and gene activity during development. Science 187 (1975) 226-232
28. Futscher B.W., Oshiro M.M., Wozniak R.J., Holtan N., Hanigan C.L., Duan H., et al. Role for DNA methylation in the control of cell type specific maspin expression. Nat Genet 31 (2002) 175-179
29. Li E., Bestor T.H., and Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69 (1992) 915-926
30. Li E., Beard C., and Jaenisch R. Role for DNA methylation in genomic imprinting. Nature 366 (1993) 362-365
31. Beard C., Li E., and Jaenisch R. Loss of methylation activates Xist in somatic but not in embryonic cells. Genes Dev 9 (1995) 2325-2334
32. Takada H., Imoto I., Tsuda H., Nakanishi Y., Ichikura T., Mochizuki H., et al. ADAM23, a possible tumor suppressor gene, is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter hypermethylation. Oncogene 24 (2005) 8051-8060
33. Douet V., Heller M.B., and Le S.O. DNA methylation and Sp1 binding determine the tissue-specific transcriptional activity of the mouse Abcc6 promoter. Biochem Biophys Res Commun 354 (2007) 66-71
34. Goll M.G., and Bestor T.H. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 74 (2005) 481-514
35. Yen R.W., Vertino P.M., Nelkin B.D., Yu J.J., el Deiry W., Cumaraswamy A., et al. Isolation and characterization of the cDNA encoding human DNA methyltransferase. Nucleic Acids Res 20 (1992) 2287-2291
36. Rountree M.R., Bachman K.E., and Baylin S.B. DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet 25 (2000) 269-277
37. Saper C.B. An open letter to our readers on the use of antibodies. J Comp Neurol 493 (2005) 477-478