Neurosteroids allosterically modulate the ion pore of the NMDA receptor consisting of NR1/NR2B but not NR1/NR2A

Biochemical and Biophysical Research Communications

Volumn 372, Issue 2, 2008, Pages 305-308

  Elfverson, Martin ^a   Linde, Anna Malin ^a   Le Grevès, Pierre ^a   Zhou, Qin ^a   Nyberg, Fred ^a   Johansson, Tobias ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

Allosteric modulation; CHO; Hippocampus; Ifenprodil; Ion channel; Kinetics; MK 801; Nanomolar; Neurosteroid; NMDA receptor; NR2B subunit; Pregnanolone; Pregnanolone sulphate; Pregnenolone; Pregnenolone sulphate; Receptor binding

Indexed keywords

IFENPRODIL; MK 801 H3; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2A; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; RADIOLIGAND;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RAT;

ALLOSTERIC REGULATION; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; HIPPOCAMPUS; ION CHANNELS; MALE; PIPERIDINES; PREGNANOLONE; PREGNENOLONE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; RECOMBINANT PROTEINS;

EID: 44649191694     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.05.055     Document Type: Article

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