Blockade of endogenous proinflammatory cytokines ameliorates endothelial dysfunction in obese Zucker rats

Hypertension Research

Volumn 31, Issue 4, 2008, Pages 737-743

  Nishimatsu, Hiroaki ^a   Suzuki, Etsu ^b   Takeda, Ryo ^a   Takahashi, Masao ^a   Oba, Shigeyoshi ^a   Kimura, Kenjiro ^b   Nagano, Tetsuo ^c   Hirata, Yasunobu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b ST MARIANNA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Adrenomedullin; Diabetes; Endothelial dysfunction; Proinflammatory cytokines

Indexed keywords

ACETYLCHOLINE; ADRENOMEDULLIN; C REACTIVE PROTEIN; CYCLIC GMP; CYTOKINE; ENDOTHELIUM DERIVED RELAXING FACTOR; INTERLEUKIN 6; PROTEIN KINASE B; SEMAPIMOD; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOKINE PRODUCTION; DIABETES MELLITUS; DRUG EFFICACY; ENDOTHELIAL DYSFUNCTION; MALE; NONHUMAN; OBESITY; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS INHIBITION; RAT; VASODILATATION; ZUCKER RAT;

ADRENOMEDULLIN; ANIMALS; BIOLOGICAL MARKERS; C-REACTIVE PROTEIN; CYCLIC GMP; ENDOTHELIUM, VASCULAR; HYDRAZONES; HYPERTENSION; IMMUNOSUPPRESSIVE AGENTS; INTERLEUKIN-6; MALE; OBESITY; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, ZUCKER; TUMOR NECROSIS FACTOR-ALPHA; VASCULITIS; VASODILATION;

EID: 44649152194     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1291/hypres.31.737     Document Type: Article

References (27)

1. Nathan DM, Meigs J, Singer DE: The epidemiology of cardiovascular disease in type 2 diabetes mellitus: how sweet it is... or is it? Lancet 1997; 350: S14-S19.
2. Wilson PW, D'Agostino RB, Sullivan L, Parise H, Kannel WB: Overweight and obesity as determinants of cardiovascular risk: the Framingham experience. Arch Intern Med 2002; 162: 1867-1872.
3. Furumoto T, Saito N, Dong J, Mikami T, Fujii S, Kitabatake A: Association of cardiovascular risk factors and endothelial dysfunction in Japanese hypertensive patients: implications for early atherosclerosis. Hypertens Res 2002; 25: 475-480.
4. Landmesser U, Hornig B, Drexler H: Endothelial function: a critical determinant in atherosclerosis? Circulation 2004; 109: II27-II33.
5. Brunner H, Cockcroft JR, Deanfield J, et al: Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005; 23: 233-246.
6. Feletou M, Vanhoutte PM: Endothelial dysfunction: a multifaceted disorder (the Wiggers Award Lecture). Am J Physiol Heart Circ Physiol 2006; 291: H985-H1002.
7. Cai H, Harrison DG: Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000; 87: 840-844.
8. Hotamisligil GS, Shargill. NS, Spiegelman BM: Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 1993; 259: 87-91.
9. Rotter V, Nagaev I, Smith U: Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects. J Biol Chem 2003; 278: 45777-45784.
10. Rask-Madsen C, Dominguez H, Ihlemann N, Hermann T, Kober L, Torp-Pedersen C: Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation 2003; 108: 1815-1821.
11. Wassmann S, Stumpf M, Strehlow K, et al: Interleukin-6 induces oxidative stress and endothelial dysfunction by overexpression of the angiotensin II type 1 receptor. Circ Res 2004; 94: 534-541.
12. 2, and iron are required for TNF-alpha-induced MCP-1 gene expression in endothelial cells: role of Rac1 and NADPH oxidase. Am J Physiol Heart Circ Physiol 2004; 286: H1001-H1007.
13. Bianchi M, Bloom O, Raabe T, et al: Suppression of proinflammatory cytokines in monocytes by a tetravalent guanylhydrazone. J Exp Med 1996; 183: 927-936.
14. Kitamura K, Kangawa K, Kawamoto M, et al: Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 1993; 192: 553-560.
15. Shindo T, Kurihara Y, Nishimatsu H, et al: Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene. Circulation 2001; 104: 1964-1971.
16. Nishimatsu H, Suzuki E, Nagata D, et al: Adrenomedullin induces endothelium-dependent vasorelaxation via the phosphatidylinositol 3-kinase/Akt-dependent pathway in rat aorta. Circ Res 2001; 89: 63-70.
17. Suzuki E, Nagata D, Yoshizumi M, et al: Reentry into the cell cycle of contact-inhibited vascular endothelial cells by a phosphatase inhibitor: possible involvement of extracellular signal-regulated kinase and phosphatidylinositol 3-kinase. J Biol Chem 2000; 275: 3637-3644.
18. Nishimatsu H, Suzuki E, Satonaka H, et al: Endothelial dysfunction and hypercontractility of vascular myocytes are ameliorated by fluvastatin in obese Zucker rats. Am J Physiol Heart Circ Physiol 2005; 288: H1770-H1776.
19. Gao X, Belmadani S, Picchi A, et al: Tumor necrosis factor-alpha induces endothelial dysfunction in Lepr(db) mice. Circulation 2007; 115: 245-254.
20. Yang B, Rizzo V: TNF-alpha potentiates protein-tyrosine nitration through activation of NADPH oxidase and eNOS localized in membrane rafts and caveolae of bovine aortic endothelial cells. Am J Physiol Heart Circ Physiol 2007; 292: H954-H962.
21. Picchi A, Gao X, Belmadani S, et al: Tumor necrosis factor-alpha induces endothelial dysfunction in the prediabetic metabolic syndrome. Circ Res 2006; 99: 69-77.
22. Kim F, Gallis B, Corson MA: TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells. Am J Physiol Cell Physiol 2001; 280: C1057-C1065.
23. Anderson HD, Rahmutula D, Gardner DG: Tumor necrosis factor-alpha inhibits endothelial nitric-oxide synthase gene promoter activity in bovine aortic endothelial cells. J Biol Chem 2004; 279: 963-969.
24. Venugopal SK, Devaraj S, Yuhanna I, Shaul P, Jialal I: Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells. Circulation 2002; 106: 1439-1441.
25. Calabro P, Willerson JT, Yeh ET: Inflammatory cytokines stimulated C-reactive protein production by human coronary artery smooth muscle cells. Circulation 2003; 108: 1930-1932.
26. Wang CH, Li SH, Weisel RD, et al: C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle. Circulation 2003; 107: 1783-1790.
27. Chang JW, Kim CS, Kim SB, Park SK, Park JS, Lee SK: C-reactive protein induces NF-kappaB activation through intracellular calcium and ROS in human mesangial cells. Nephron Exp Nephrol 2005; 101: e165-e172.