메뉴 건너뛰기




Volumn 246, Issue 7, 2008, Pages 979-988

Intrinsic tissue fluorescence in an organotypic perfusion culture of the porcine ocular fundus exposed to blue light and free radicals

Author keywords

Autofluorescence; Fluorescence spectroscopy; Lipofuscin; Ocular fundus; Organ culture

Indexed keywords

ETHANOLAMINE DERIVATIVE; FREE RADICAL; HYDROGEN PEROXIDE; LIPOFUSCIN;

EID: 44649123640     PISSN: 0721832X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00417-008-0789-4     Document Type: Article
Times cited : (17)

References (45)
  • 2
    • 0019793660 scopus 로고
    • The distribution of peroxide regulating enzymes in the canine eye
    • Armstrong D, Santangelo G, Connole E (1981) The distribution of peroxide regulating enzymes in the canine eye. Curr Eye Res 1:225-242
    • (1981) Curr Eye Res , vol.1 , pp. 225-242
    • Armstrong, D.1    Santangelo, G.2    Connole, E.3
  • 6
    • 4344667576 scopus 로고    scopus 로고
    • Intraretinal oxygenation and oxygen consumption in the rabbit during systemic hyperoxia
    • Cringle SJ, Yu DY (2004) Intraretinal oxygenation and oxygen consumption in the rabbit during systemic hyperoxia. Invest Ophthalmol Vis Sci 45:3223-3228
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 3223-3228
    • Cringle, S.J.1    Yu, D.Y.2
  • 7
    • 0026712171 scopus 로고
    • Lipid peroxidation - A common pathogenetic mechanism?
    • Dargel R (1992) Lipid peroxidation - A common pathogenetic mechanism? Exp Toxicol Pathol 44:169-181
    • (1992) Exp Toxicol Pathol , vol.44 , pp. 169-181
    • Dargel, R.1
  • 8
    • 0028539157 scopus 로고
    • Spectrometer for noninvasive measurement of intrinsic fluorescence and reflectance of ocular fundus
    • Delori FC (1994) Spectrometer for noninvasive measurement of intrinsic fluorescence and reflectance of ocular fundus. Applied Optics 33:7439-7452
    • (1994) Applied Optics , vol.33 , pp. 7439-7452
    • Delori, F.C.1
  • 9
    • 0028953831 scopus 로고
    • In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics
    • Delori FC, Dorey KC, Staurenghi G, Arend O, Goger DC, Weiter JJ (1995) In vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristics. Invest Ophthalmol 36:718-729
    • (1995) Invest Ophthalmol , vol.36 , pp. 718-729
    • Delori, F.C.1    Dorey, K.C.2    Staurenghi, G.3    Arend, O.4    Goger, D.C.5    Weiter, J.J.6
  • 11
    • 20444496147 scopus 로고    scopus 로고
    • Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: A prospective study
    • Einbock W, Moessner A, Schnurrbusch UE, Holz FG, Wolf S (2005) Changes in fundus autofluorescence in patients with age-related maculopathy. Correlation to visual function: A prospective study. Graefes Arch Clin Exp Ophthalmol 243:300-305
    • (2005) Graefes Arch Clin Exp Ophthalmol , vol.243 , pp. 300-305
    • Einbock, W.1    Moessner, A.2    Schnurrbusch, U.E.3    Holz, F.G.4    Wolf, S.5
  • 12
    • 0027410970 scopus 로고
    • Retinal age-pigments generated by self-assembling lysomorphotropic detergents
    • Eldred GE, Lasky MR (1993) Retinal age-pigments generated by self-assembling lysomorphotropic detergents. Nature 361:724-726
    • (1993) Nature , vol.361 , pp. 724-726
    • Eldred, G.E.1    Lasky, M.R.2
  • 14
    • 0142242222 scopus 로고    scopus 로고
    • Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration
    • Gu X, Meer SG, Miyagi M, Rayborn ME, Hollyfield JG, Crabb JW, Salomon RG (2003) Carboxyethylpyrrole protein adducts and autoantibodies, biomarkers for age-related macular degeneration. J Biol Chem 278:42027-42035
    • (2003) J Biol Chem , vol.278 , pp. 42027-42035
    • Gu, X.1    Meer, S.G.2    Miyagi, M.3    Rayborn, M.E.4    Hollyfield, J.G.5    Crabb, J.W.6    Salomon, R.G.7
  • 15
    • 33750898645 scopus 로고    scopus 로고
    • Retinal pigment epithelium cell damage by A2-E and its photo-derivatives
    • Hammer M, Richter S, Guehrs KH, Schweitzer D (2006) Retinal pigment epithelium cell damage by A2-E and its photo-derivatives. Mol Vis 12:1348-1354
    • (2006) Mol Vis , vol.12 , pp. 1348-1354
    • Hammer, M.1    Richter, S.2    Guehrs, K.H.3    Schweitzer, D.4
  • 18
    • 0035069027 scopus 로고    scopus 로고
    • Fundus autofluorescence and development of geographic atrophy in age- related macular degeneration
    • Holz FG, Bellman C, Staudt S, Schutt F, Volcker HE (2001) Fundus autofluorescence and development of geographic atrophy in age- related macular degeneration. Invest Ophthalmol Vis Sci 42:1051-1056
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1051-1056
    • Holz, F.G.1    Bellman, C.2    Staudt, S.3    Schutt, F.4    Volcker, H.E.5
  • 19
    • 55149086926 scopus 로고    scopus 로고
    • Transport characteristics of ageing Bruch's Membrane: Implications for age-related macular degeneration
    • In: Ioseliani OR (ed) Nova Biomedical Books, New York
    • Hussain AA, Starita C, Marshall J (2003) Transport characteristics of ageing Bruch's Membrane: Implications for age-related macular degeneration. In: Ioseliani OR (ed) Focus on macular degeneration research. Nova Biomedical Books, New York, pp 59-113
    • (2003) Focus on Macular Degeneration Research , pp. 59-113
    • Hussain, A.A.1    Starita, C.2    Marshall, J.3
  • 20
    • 28844447280 scopus 로고    scopus 로고
    • Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin
    • Jang YP, Matsuda H, Itagaki Y, Nakanishi K, Sparrow JR (2005) Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse retinal pigment epithelial cell lipofuscin. J Biol Chem 280:39732-39739
    • (2005) J Biol Chem , vol.280 , pp. 39732-39739
    • Jang, Y.P.1    Matsuda, H.2    Itagaki, Y.3    Nakanishi, K.4    Sparrow, J.R.5
  • 21
    • 13944264719 scopus 로고    scopus 로고
    • RPE65 gene mutation prevents development of autofluorescence in retinal pigment epithelial phagosomes
    • Katz ML, Wendt KD, Sanders DN (2005) RPE65 gene mutation prevents development of autofluorescence in retinal pigment epithelial phagosomes. Mech Ageing Dev 126:513-521
    • (2005) Mech Ageing Dev , vol.126 , pp. 513-521
    • Katz, M.L.1    Wendt, K.D.2    Sanders, D.N.3
  • 22
    • 41049091678 scopus 로고    scopus 로고
    • Maintenance of adult porcine retina and retinal pigment epithelium in perfusion culture: Characterisation of an organotypic in-vitro model
    • DOI 10.1016/j.exer.2008.01.011
    • Kobuch K, Herrmann AW, Framme C, Sachs HG, Gabel VP, Hillenkamp J (2008) Maintenance of adult porcine retina and retinal pigment epithelium in perfusion culture: Characterisation of an organotypic in-vitro model. Exp Eye Res. DOI 10.1016/j.exer.2008.01.011
    • (2008) Exp Eye Res
    • Kobuch, K.1    Herrmann, A.W.2    Framme, C.3    Sachs, H.G.4    Gabel, V.P.5    Hillenkamp, J.6
  • 23
    • 10044255422 scopus 로고    scopus 로고
    • Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration
    • Kopitz J, Holz FG, Kaemmerer E, Schutt F (2004) Lipids and lipid peroxidation products in the pathogenesis of age-related macular degeneration. Biochimie 86:825-831
    • (2004) Biochimie , vol.86 , pp. 825-831
    • Kopitz, J.1    Holz, F.G.2    Kaemmerer, E.3    Schutt, F.4
  • 24
    • 0023464342 scopus 로고
    • Free radical tissue damage: Protective role of antioxidant nutrients
    • Machlin LJ, Bendich A (1987) Free radical tissue damage: Protective role of antioxidant nutrients. FASEB J 1:441-445
    • (1987) FASEB J , vol.1 , pp. 441-445
    • Machlin, L.J.1    Bendich, A.2
  • 25
    • 0036293752 scopus 로고    scopus 로고
    • Spectral profiling of autofluorescence associated with lipofuscin, Bruch's Membrane, and sub-RPE deposits in normal and AMD eyes
    • Marmorstein AD, Marmorstein LY, Sakaguchi H, Hollyfield JG (2002) Spectral profiling of autofluorescence associated with lipofuscin, Bruch's Membrane, and sub-RPE deposits in normal and AMD eyes. Invest Ophthalmol Vis Sci 43:2435-2441
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 2435-2441
    • Marmorstein, A.D.1    Marmorstein, L.Y.2    Sakaguchi, H.3    Hollyfield, J.G.4
  • 26
    • 0347052871 scopus 로고    scopus 로고
    • Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells
    • Mata NL, Moghrabi WN, Lee JS, Bui TV, Radu RA, Horwitz J, Travis GH (2004) Rpe65 is a retinyl ester binding protein that presents insoluble substrate to the isomerase in retinal pigment epithelial cells. J Biol Chem 279:635-643
    • (2004) J Biol Chem , vol.279 , pp. 635-643
    • Mata, N.L.1    Moghrabi, W.N.2    Lee, J.S.3    Bui, T.V.4    Radu, R.A.5    Horwitz, J.6    Travis, G.H.7
  • 27
    • 0034944895 scopus 로고    scopus 로고
    • Delayed dark-adaptation and lipofuscin accumulation in abcr/- mice: Implications for involvement of ABCR in age-related macular degeneration
    • Mata NL, Tzekov RT, Liu X, Weng J, Birch DG, Travis GH (2001) Delayed dark-adaptation and lipofuscin accumulation in abcr/- mice: implications for involvement of ABCR in age-related macular degeneration. Invest Ophthalmol Vis Sci 42:1685-1690
    • (2001) Invest Ophthalmol Vis Sci , vol.42 , pp. 1685-1690
    • Mata, N.L.1    Tzekov, R.T.2    Liu, X.3    Weng, J.4    Birch, D.G.5    Travis, G.H.6
  • 28
    • 0037233423 scopus 로고    scopus 로고
    • Aging of cultured retinal pigment epithelial cells: Oxidative reactions, lipofuscin formation and blue light damage
    • Nilsson SE, Sundelin SP, Wihlmark U, Brunk UT (2003) Aging of cultured retinal pigment epithelial cells: Oxidative reactions, lipofuscin formation and blue light damage. Doc Ophthalmol 106:13-16
    • (2003) Doc Ophthalmol , vol.106 , pp. 13-16
    • Nilsson, S.E.1    Sundelin, S.P.2    Wihlmark, U.3    Brunk, U.T.4
  • 29
    • 0032438193 scopus 로고    scopus 로고
    • Isolation and one step preparation of A2-E and iso-A2-E fluorophores from human retinal pigment epithelium
    • Parish CA, Hashimoto M, Nakanishi K, Dillon J, Sparrow J (1998) Isolation and one step preparation of A2-E and iso-A2-E fluorophores from human retinal pigment epithelium. Proc Natl Acad Sci USA 95:14609-14613
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 14609-14613
    • Parish, C.A.1    Hashimoto, M.2    Nakanishi, K.3    Dillon, J.4    Sparrow, J.5
  • 31
    • 1942533542 scopus 로고    scopus 로고
    • Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration
    • Radu RA, Mata NL, Bagla A, Travis GH (2004) Light exposure stimulates formation of A2E oxiranes in a mouse model of Stargardt's macular degeneration. Proc Natl Acad Sci USA 101:5928-5933
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 5928-5933
    • Radu, R.A.1    Mata, N.L.2    Bagla, A.3    Travis, G.H.4
  • 32
    • 33751566190 scopus 로고    scopus 로고
    • Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration
    • discussion 63-7, 177-8
    • Radu RA, Mata NL, Nusinowitz S, Liu X, Travis GH (2004) Isotretinoin treatment inhibits lipofuscin accumulation in a mouse model of recessive Stargardt's macular degeneration. Novartis Found Symp 255:51-63, discussion 63-7, 177-8
    • (2004) Novartis Found Symp , vol.255 , pp. 51-63
    • Radu, R.A.1    Mata, N.L.2    Nusinowitz, S.3    Liu, X.4    Travis, G.H.5
  • 34
    • 0041342065 scopus 로고    scopus 로고
    • Proteins modified by Malondialdehyde, 4-Hydroxynonenal, or advanced glycation end products in Lipofuscin of human retinal pigment epithelium
    • Schütt F, Bergmann M, Holz FG, Kopitz J (2003) Proteins modified by Malondialdehyde, 4-Hydroxynonenal, or advanced glycation end products in Lipofuscin of human retinal pigment epithelium. Invest Ophthalmol Vis Sci 44:3663-3668
    • (2003) Invest Ophthalmol Vis Sci , vol.44 , pp. 3663-3668
    • Schütt, F.1    Bergmann, M.2    Holz, F.G.3    Kopitz, J.4
  • 36
    • 0033499606 scopus 로고    scopus 로고
    • Characterization of peroxidized lipids in Bruch's membrane
    • Spaide RF, Ho-Spaide WC, Browne RW, Armstrong D (1999) Characterization of peroxidized lipids in Bruch's membrane. Retina 19:141-147
    • (1999) Retina , vol.19 , pp. 141-147
    • Spaide, R.F.1    Ho-Spaide, W.C.2    Browne, R.W.3    Armstrong, D.4
  • 37
    • 18044366931 scopus 로고    scopus 로고
    • RPE lipofuscin and its role in retinal pathobiology
    • Sparrow JR, Boulton M (2005) RPE lipofuscin and its role in retinal pathobiology. Exp Eye Res 80:595-606
    • (2005) Exp Eye Res , vol.80 , pp. 595-606
    • Sparrow, J.R.1    Boulton, M.2
  • 38
    • 0032710514 scopus 로고    scopus 로고
    • A2E, a Lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture
    • Sparrow JR, Parish CA, Hashimoto M, Nakanishi K (1999) A2E, a Lipofuscin fluorophore, in human retinal pigmented epithelial cells in culture. Invest Ophthalmol Vis Sci 40:2988-2995
    • (1999) Invest Ophthalmol Vis Sci , vol.40 , pp. 2988-2995
    • Sparrow, J.R.1    Parish, C.A.2    Hashimoto, M.3    Nakanishi, K.4
  • 39
    • 0029950660 scopus 로고    scopus 로고
    • Hydrodynamics of ageing Bruch's membrane: Implications for macular disease
    • Starita C, Hussain AA, Pagliarini S, Marshall J (1996) Hydrodynamics of ageing Bruch's membrane: Implications for macular disease. Exp Eye Res 62:565-572
    • (1996) Exp Eye Res , vol.62 , pp. 565-572
    • Starita, C.1    Hussain, A.A.2    Pagliarini, S.3    Marshall, J.4
  • 40
    • 4544383322 scopus 로고    scopus 로고
    • Controlled respiratory gas delivery to embryonic renal epithelial explants in perfusion culture
    • Strehl R, Schumacher K, Minuth WW (2004) Controlled respiratory gas delivery to embryonic renal epithelial explants in perfusion culture. Tissue Eng 10:1196-1203
    • (2004) Tissue Eng , vol.10 , pp. 1196-1203
    • Strehl, R.1    Schumacher, K.2    Minuth, W.W.3
  • 41
    • 0035191280 scopus 로고    scopus 로고
    • Lipofuscin-formation in cultured retinal pigment epithelial cells is related to their melanin content
    • Sundelin SP, Nilsson SE, Brunk UT (2001) Lipofuscin-formation in cultured retinal pigment epithelial cells is related to their melanin content. Free Radic Biol Med 30:74-81
    • (2001) Free Radic Biol Med , vol.30 , pp. 74-81
    • Sundelin, S.P.1    Nilsson, S.E.2    Brunk, U.T.3
  • 42
    • 0029022639 scopus 로고
    • Distribution of fundus autofluorescence with a scanning laser ophthalmoscope
    • von Rückmann A, Fitzke FW, Bird AC (1995) Distribution of fundus autofluorescence with a scanning laser ophthalmoscope. Brit J Ophthalmol 79:407-412
    • (1995) Brit J Ophthalmol , vol.79 , pp. 407-412
    • von Rückmann, A.1    Fitzke, F.W.2    Bird, A.C.3
  • 43
    • 0344830731 scopus 로고    scopus 로고
    • Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope
    • von Rückmann A, Fitzke FW, Bird AC (1997) Fundus autofluorescence in age-related macular disease imaged with a laser scanning ophthalmoscope. Invest Ophthalmol Vis Sci 38:478-486
    • (1997) Invest Ophthalmol Vis Sci , vol.38 , pp. 478-486
    • von Rückmann, A.1    Fitzke, F.W.2    Bird, A.C.3
  • 44
    • 0031777041 scopus 로고    scopus 로고
    • Fluorescence properties of autofluorescent granules generated by cultured human RPE cells
    • Wassell J, Ellis S, Burke J, Boulton M (1998) Fluorescence properties of autofluorescent granules generated by cultured human RPE cells. Invest Ophthalmol Vis Sci 39:1487-1492
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 1487-1492
    • Wassell, J.1    Ellis, S.2    Burke, J.3    Boulton, M.4
  • 45
    • 0030943224 scopus 로고    scopus 로고
    • Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation
    • Wihlmark U, Wrigstad A, Roberg K, Nilsson SE, Brunk UT (1997) Lipofuscin accumulation in cultured retinal pigment epithelial cells causes enhanced sensitivity to blue light irradiation. Free Radic Biol Med 22:1229-1234
    • (1997) Free Radic Biol Med , vol.22 , pp. 1229-1234
    • Wihlmark, U.1    Wrigstad, A.2    Roberg, K.3    Nilsson, S.E.4    Brunk, U.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.