Human cytomegalovirus infection induces a rapid and sustained change in the expression of NK cell receptors on CD8+T cells

Journal of Immunology

Volumn 180, Issue 7, 2008, Pages 4550-4560

  Van Stijn, Amber ^a,b,c   Rowshani, Ajda T ^b   Yong, Sila L ^a   Baas, Frank ^c   Roosnek, Eddy ^d   Ten Berge, Ineke J M ^b   Van Lier, René A W ^a  

^a Department of Experimental Immunology ^*  (Netherlands)

^b Division of Nephrology   (Netherlands)

^c ACADEMIC MEDICAL CENTER   (Netherlands)

^d GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BASILIXIMAB; CD94 ANTIGEN; CYCLOSPORIN; GANCICLOVIR; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2C; PREDNISOLONE; UNCLASSIFIED DRUG; IMMUNOGLOBULIN RECEPTOR;

ACUTE DISEASE; ADULT; AGED; ARTICLE; CD3+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL SURFACE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; DNA MICROARRAY; FLOW CYTOMETRY; GRAFT RECIPIENT; GRAFT VERSUS HOST REACTION; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; KIDNEY TRANSPLANTATION; KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; VIRUS REPLICATION; DIMERIZATION; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NATURAL KILLER CELL; TIME;

ADULT; AGED; ANTIGENS, CD94; CD8-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS INFECTIONS; DIMERIZATION; GENE EXPRESSION REGULATION; HUMANS; KILLER CELLS, NATURAL; KINETICS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RECEPTORS, IMMUNOLOGIC; TIME FACTORS;

EID: 44449168693     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.180.7.4550     Document Type: Article

References (36)

1. Rowshani, A. T., F. J. Bemelman, E. M. van Leeuwen, R. A. van Lier, and I. ten Berge. 2005. Clinical and immunologic aspects of cytomegalovirus infection in solid organ transplant recipients. Transplantation 79: 381-386.
2. Polic, B., H. Hengel, A. Krmpotic, J. Trgovcich, I. Pavic, P. Luccaronin, S. Jonjic, and U. H. Koszinowski. 1998. Hierarchical and redundant lymphocyte subset control precludes cytomegalovirus replication during latent infection. J. Exp. Med. 188: 1047-1054.
3. + T cells vary in differentiation phenotype in different persistent virus infections. Nat. Med. 8: 379-385.
4. + CTLs ex vivo. J. Immunol. 168: 5954-5958.
5. +, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J. Immunol. 173: 1834-1841.
6. + T lymphocytes depend on infection with CMV. J. Immunol. 170: 4342-4348.
7. + T-cell differentiation in response to viruses. Nat. Rev. Immunol. 3: 931-939.
8. + T cells in protection against CMV disease. Blood 101: 2686 - 2692.
9. Groh, V., R. Rhinehart, J. Randolph-Habecker, M. S. Topp, S. R. Riddell, and T. Spies. 2001. Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2: 255-260.
10. Mandelboim, O., D. M. Davis, H. T. Reyburn, M. Vales-Gomez, E. G. Sheu, L. Pazmany, and J. L. Strominger. 1996. Enhancement of class II-restricted Tcell responses by costimulatory NK receptors for class I MHC proteins. Science 274: 2097-2100.
11. null T cells clonally expanded in rheumatoid arthritis. J. Immunol. 165: 1138 - 1145.
12. + natural killer (NK) cells by the expression of clonally distributed functional surface molecules: correlation between subset assignment of NK clones and ability to mediate specific alloantigen recognition. J. Exp. Med. 172: 1589-1598.
13. Moretta, A., M. Vitale, C. Bottino, A. M. Orengo, L. Morelli, R. Augugliaro, M. Barbaresi, E. Ciccone, and L. Moretta. 1993. P58 molecules as putative receptors for major histocompatibility complex (MHC) class I molecules in human natural killer (NK) cells: anti-p58 antibodies reconstitute lysis of MHC class I-protected cells in NK clones displaying different specificities. J. Exp. Med. 178: 597-604.
14. Vitale, M., S. Sivori, D. Pende, L. Moretta, and A. Moretta. 1995. Coexpression of two functionally independent p58 inhibitory receptors in human natural killer cell clones results in the inability to kill all normal allogeneic target cells. Proc. Natl. Acad. Sci. USA 92: 3536-3540.
15. lck kinase. Eur. J. Immunol. 24: 2527-2534.
16. + T cells in healthy and immu - nosuppressed virus carriers. Blood 98: 754-761.
17. Guma, M., A. Angulo, C. Vilches, N. Gomez-Lozano, N. Malats, and M. Lopez-Botet. 2004. Imprint of human cytomegalovirus infection on the NK cell receptor repertoire. Blood 104: 3664-3671.
18. Ferrini, S., A. Cambiaggi, R. Meazza, S. Sforzini, S. Marciano, M. C. Mingari, and L. Moretta. 1994. T cell clones expressing the natural killer cell-related p58 receptor molecule display heterogeneity in phenotypic properties and p58 function. Eur. J. Immunol. 24: 2294-2298.
19. Mingari, M. C., C. Vitale, A. Cambiaggi, F. Schiavetti, G. Melioli, S. Ferrini, and A. Poggi. 1995. Cytolytic T lymphocytes displaying natural killer (NK)-like activity: expression of NK-related functional receptors for HLA class I molecules (p58 and CD94) and inhibitory effect on the TCR-mediated target cell lysis or lymphokine production. Int. Immunol. 7: 697-703.
20. + T lymphocyte subsets that express HLA class I-specific inhibitory receptors represent oligoclonally or monoclonally expanded cell populations. Proc. Natl. Acad. Sci. USA 93: 12433-12438.
21. Mingari, M. C., M. Ponte, C. Cantoni, C. Vitale, F. Schiavetti, S. Bertone, R. Bellomo, A. T. Cappai, and R. Biassoni. 1997. HLA-class I-specific inhibitory receptors in human cytolytic T lymphocytes: molecular characterization, distribution in lymphoid tissues and co-expression by individual T cells. Int. Immunol. 9: 485-491.
22. Jamieson, A. M., A. Diefenbach, C. W. McMahon, N. Xiong, J. R. Carlyle, and D. H. Raulet. 2002. The role of the NKG2D immunoreceptor in immune cell activation and natural killing. Immunity 17: 19 - 29.
23. + T lymphocytes during active, latent, and resolved infection and its relation with CD57. J. Immunol. 174: 6088 - 6094.
24. + T cell responses. Nat. Immunol. 3: 189-195.
25. Snydman, D. R., B. G. Werner, B. Heinze-Lacey, V. P. Berardi, N. L. Tilney, R. L. Kirkman, E. L. Milford, S. I. Cho, H. L. Bush, Jr., A. S. Levey, et al. 1987. Use of cytomegalovirus immune globulin to prevent cytomegalovirus disease in renal-transplant recipients. N. Engl. J. Med. 317: 1049-1054.
26. Uhrberg, M., N. M. Valiante, B. P. Shum, H. G. Shilling, K. Lienert-Weidenbach, B. Corliss, D. Tyan, L. L. Lanier, and P. Parham. 1997. Human diversity in killer cell inhibitory receptor genes. Immunity 7: 753-763.
27. + TCR αβ lymphocytes. Eur. J. Immunol. 34: 3456 - 3464.
28. + T cells. J. Immunol. 173: 7223-7229.
29. + T cell frequencies by flow cytometry: evidence for a novel, antigen-specific homeostatic mechanism in HIV-associated immunodeficiency. J. Clin. Invest 99: 1739-1750.
30. Cantoni, C., C. Bottino, M. Vitale, A. Pessino, R. Augugliaro, A. Malaspina, S. Parolini, L. Moretta, A. Moretta, and R. Biassoni. 1999. NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J. Exp. Med. 189: 787-796.
31. Vitale, M., C. Bottino, S. Sivori, L. Sanseverino, R. Castriconi, E. Marcenaro, R. Augugliaro, L. Moretta, and A. Moretta. 1998. NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J. Exp. Med. 187: 2065-2072.
32. Kaiser, B. K., F. Barahmand-Pour, W. Paulsene, S. Medley, D. E. Geraghty, and R. K. Strong. 2005. Interactions between NKG2x immunoreceptors and HLA-E ligands display overlapping affinities and thermodynamics. J. Immunol 174: 2878 - 2884.
33. Noppen, C., C. Schaefer, P. Zajac, A. Schutz, T. Kocher, J. Kloth, M. Heberer, M. Colonna, G. De Libero, and G. C. Spagnoli. 1998. C-type lectin-like receptors in peptide-specific HLA class I-restricted cytotoxic T lymphocytes: differential expression and modulation of effector functions in clones sharing identical TCR structure and epitope specificity. Eur. J. Immunol. 28: 1134-1142.
34. Saverino, D., M. Fabbi, F. Ghiotto, A. Merlo, S. Bruno, D. Zarcone, C. Tenca, M. Tiso, G. Santoro, G. Anastasi, et al. 2000. The CD85/LIR-1/ILT2 inhibitory receptor is expressed by all human T lymphocytes and down-regulates their functions. J. Immunol. 165: 3742-3775.
35. D'Andrea, A., C. Chang, J. H. Phillips, and L. L. Lanier. 1996. Regulation of T cell lymphokine production by killer cell inhibitory receptor recognition of self HLA class I alleles. J. Exp. Med. 184: 789-794.
36. Henel, G., K. Singh, D. Cui, S. Pryshchep, W. W. Lee, C. M. Weyand, and J. J. Goronzy. 2006. Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors. Blood 107: 4449-4457.