Enzyme loaded biodegradable microspheres in vitro - Ex vivo evaluation

Journal of Controlled Release

Volumn 77, Issue 3, 2001, Pages 287-295

  Genta, I ^a   Perugini, P ^a   Pavanetto, F ^a   Maculotti, K ^a   Modena, T ^a   Casado, B ^a   Lupi, A ^a   Iadarola, P ^a   Conti, B ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Biodegradable microspheres; Enzyme delivery; Ex vivo evaluation; Prolidase; Sustained release

Indexed keywords

CELL EXTRACT; ENZYME; MICROSPHERE; POLYGLACTIN; PROLINE DIPEPTIDASE; PROTEIN;

ADULT; ARTICLE; BIODEGRADATION; CASE REPORT; CELL CULTURE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG SOLUBILITY; EMULSION; ENZYME ACTIVITY; ENZYME DEFICIENCY; ENZYME RELEASE; ENZYME REPLACEMENT; ENZYME STABILITY; EVAPORATION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MALE; MICROENCAPSULATION; PRIORITY JOURNAL; PROTEIN CONTENT; SKIN FIBROBLAST; SKIN ULCER;

ADULT; ANIMALS; BIODEGRADATION, ENVIRONMENTAL; CELLS, CULTURED; DIPEPTIDASES; DRUG EVALUATION; ENZYME ACTIVATION; ENZYMES, IMMOBILIZED; FEMALE; FIBROBLASTS; HUMANS; MALE; MICROSPHERES; MIDDLE AGED; SKIN; SWINE;

EID: 0035856849     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(01)00511-9     Document Type: Article

References (20)

1. Minireview on prolidase and prolidase deficiency
2. Prolidase deficiency: Biochemical classification of the alleles
3. Biochemical basis of prolidase deficiency
4. Four novel PEPD alleles causing prolidase deficiency
5. Prolidase deficiency
6. Prolidase deficiency: A multisystemic hereditary disorder
7. Topical treatment of skin ulcers in prolidase deficiency
8. Stability of proteins and their delivery from biodegradable polymer microspheres
9. Formulation of L-asparaginase-loaded poly(lactide-co-glycolide) nanopartciles: Influence of polymer properties on enzyme loading, activity and in vitro release
10. Effects of salt addition on the microencapsulation of proteins using W-O-W double emulsion technique
11. Stabilization of proteins against methylene chloride-water interface-induced denaturation and aggregation
12. Influence of process parameters on the protein stability encapsulated in poly-D,L-lactide-poly(ethylene glycol) microspheres
13. Prolidase interaction with PLGA and its microencapsulation
14. Peptide containing microspheres from low molecular weight and hydrophilic poly(D,L-lactide-co-glycolide)
15. Peptide release from hydrophilic and hydrophobic PLGA polymers
16. High-performance liquid chromatography procedure for the determination of serum prolidase activity
17. A de novo G to T in a pro-alpha1 (I) collagen gene for a moderate case of osteogenesis imperfecta. Substitution of cysteine for glycine 178 in the triple helical domain
18. Photometric estimation of proline and ornithine
19. Cleavage of structural protein during the assembly of the head of bacteriophage T4
20. Prolidase in human breast cancer MCF-7 cells