-
1
-
-
0031912695
-
Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid
-
Kruczynski A., Colpaert F., Tarayre J.P., Mouillard P., Fahy J., and Hill B.T. Preclinical in vivo antitumor activity of vinflunine, a novel fluorinated Vinca alkaloid. Cancer Chemother Pharmacol 41 (1998) 437-447
-
(1998)
Cancer Chemother Pharmacol
, vol.41
, pp. 437-447
-
-
Kruczynski, A.1
Colpaert, F.2
Tarayre, J.P.3
Mouillard, P.4
Fahy, J.5
Hill, B.T.6
-
2
-
-
0024391924
-
Experimental antitumor activity of Navelbine
-
Cros S., Wright M., Morimoto M., Lataste H., Couzinier J.P., and Krikorian A. Experimental antitumor activity of Navelbine. Semin Oncol 16 Suppl 4 (1989) 15-20
-
(1989)
Semin Oncol
, vol.16
, Issue.SUPPL. 4
, pp. 15-20
-
-
Cros, S.1
Wright, M.2
Morimoto, M.3
Lataste, H.4
Couzinier, J.P.5
Krikorian, A.6
-
3
-
-
0033105721
-
Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts
-
Hill B.T., Fiebig H.H., Waud W.R., Poupon M.F., Colpaert F., and Kruczynski A. Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts. Eur J Cancer 35 (1999) 512-520
-
(1999)
Eur J Cancer
, vol.35
, pp. 512-520
-
-
Hill, B.T.1
Fiebig, H.H.2
Waud, W.R.3
Poupon, M.F.4
Colpaert, F.5
Kruczynski, A.6
-
4
-
-
0034773326
-
Vinflunine, the latest Vinca alkaloid in clinical development. A review of its preclinical anticancer properties
-
Kruczynski A., and Hill B.T. Vinflunine, the latest Vinca alkaloid in clinical development. A review of its preclinical anticancer properties. Crit Rev Oncol Hematol 40 (2001) 159-173
-
(2001)
Crit Rev Oncol Hematol
, vol.40
, pp. 159-173
-
-
Kruczynski, A.1
Hill, B.T.2
-
5
-
-
0035986530
-
Higher antitumor activity of vinflunine than vinorelbine against an orthotopic murine model of transitional cell carcinoma of the bladder
-
Bonfil R.D., Russo D.M., Binda M.M., Delgado F.M., and Vincenti M. Higher antitumor activity of vinflunine than vinorelbine against an orthotopic murine model of transitional cell carcinoma of the bladder. Urol Oncol 7 (2002) 159-166
-
(2002)
Urol Oncol
, vol.7
, pp. 159-166
-
-
Bonfil, R.D.1
Russo, D.M.2
Binda, M.M.3
Delgado, F.M.4
Vincenti, M.5
-
6
-
-
0032031453
-
Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid
-
Kruczynski A., Barret J.M., Etievant C., Colpaert F., Fahy J., and Hill B.T. Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated Vinca alkaloid. Biochem Pharmacol 55 (1998) 635-648
-
(1998)
Biochem Pharmacol
, vol.55
, pp. 635-648
-
-
Kruczynski, A.1
Barret, J.M.2
Etievant, C.3
Colpaert, F.4
Fahy, J.5
Hill, B.T.6
-
7
-
-
0038674316
-
The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics
-
Okouneva T., Hill B.T., Wilson L., and Jordan M.A. The effects of vinflunine, vinorelbine, and vinblastine on centromere dynamics. Mol Cancer Ther 2 (2003) 427-436
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 427-436
-
-
Okouneva, T.1
Hill, B.T.2
Wilson, L.3
Jordan, M.A.4
-
8
-
-
4944234717
-
Low concentrations of vinflunine induce apoptosis in human SK-N-SH neuroblastoma cells through a postmitotic G1 arrest and a mitochondrial pathway
-
Pourroy B., Carre M., Honore S., Bourgarel-Rey V., Kruczynski A., Briand C., et al. Low concentrations of vinflunine induce apoptosis in human SK-N-SH neuroblastoma cells through a postmitotic G1 arrest and a mitochondrial pathway. Mol Pharmacol 66 (2004) 580-591
-
(2004)
Mol Pharmacol
, vol.66
, pp. 580-591
-
-
Pourroy, B.1
Carre, M.2
Honore, S.3
Bourgarel-Rey, V.4
Kruczynski, A.5
Briand, C.6
-
9
-
-
0031813790
-
Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase
-
Srivastava R.K., Srivastava A.R., Korsmeyer S.J., Nesterova M., Cho-Chung Y.S., and Longo D.L. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol Cell Biol 18 (1998) 3509-3517
-
(1998)
Mol Cell Biol
, vol.18
, pp. 3509-3517
-
-
Srivastava, R.K.1
Srivastava, A.R.2
Korsmeyer, S.J.3
Nesterova, M.4
Cho-Chung, Y.S.5
Longo, D.L.6
-
10
-
-
0031652750
-
Vinorelbine induces apoptosis and caspase-3 (CPP32) expression in leukemia and lymphoma cells: a comparison with vincristine
-
Toh H.C., Sun L., Koh C.H., and Aw S.E. Vinorelbine induces apoptosis and caspase-3 (CPP32) expression in leukemia and lymphoma cells: a comparison with vincristine. Leuk Lymphoma 31 (1998) 195-208
-
(1998)
Leuk Lymphoma
, vol.31
, pp. 195-208
-
-
Toh, H.C.1
Sun, L.2
Koh, C.H.3
Aw, S.E.4
-
11
-
-
0030829777
-
Apoptosis: an overview
-
Wyllie A.H. Apoptosis: an overview. Br Med Bull 53 (1997) 451-465
-
(1997)
Br Med Bull
, vol.53
, pp. 451-465
-
-
Wyllie, A.H.1
-
12
-
-
0031080248
-
The role of the Caspase family of cysteine proteases in apoptosis
-
Miller D.K. The role of the Caspase family of cysteine proteases in apoptosis. Semin Immunol 9 (1997) 35-49
-
(1997)
Semin Immunol
, vol.9
, pp. 35-49
-
-
Miller, D.K.1
-
13
-
-
37449016064
-
Microtubules in apoptosis induction: Are they necessary?
-
Esteve M.A., Carré M., and Braguer D. Microtubules in apoptosis induction: Are they necessary?. Curr Cancer Drug Targets 7 (2007) 325-334
-
(2007)
Curr Cancer Drug Targets
, vol.7
, pp. 325-334
-
-
Esteve, M.A.1
Carré, M.2
Braguer, D.3
-
14
-
-
0032880829
-
The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review
-
Wang L.G., Liu X.M., Kreis W., and Budman D.R. The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol 44 (1999) 355-361
-
(1999)
Cancer Chemother Pharmacol
, vol.44
, pp. 355-361
-
-
Wang, L.G.1
Liu, X.M.2
Kreis, W.3
Budman, D.R.4
-
15
-
-
0034627879
-
Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells
-
Stone A.A., and Chambers T.C. Microtubule inhibitors elicit differential effects on MAP kinase (JNK, ERK, and p38) signaling pathways in human KB-3 carcinoma cells. Exp Cell Res 254 (2000) 110-119
-
(2000)
Exp Cell Res
, vol.254
, pp. 110-119
-
-
Stone, A.A.1
Chambers, T.C.2
-
16
-
-
0037033711
-
Characterization of cell death induced by vinflunine, the most recent Vinca alkaloid in clinical development
-
Kruczynski A., Etievant C., Perrin D., Chansard N., Duflos A., and Hill B.T. Characterization of cell death induced by vinflunine, the most recent Vinca alkaloid in clinical development. Br J Cancer 86 (2002) 143-150
-
(2002)
Br J Cancer
, vol.86
, pp. 143-150
-
-
Kruczynski, A.1
Etievant, C.2
Perrin, D.3
Chansard, N.4
Duflos, A.5
Hill, B.T.6
-
17
-
-
0032570594
-
Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways
-
Wang T.H., Wang H.S., Ichijo H., Giannakakou P., Foster J.S., Fojo T., et al. Microtubule-interfering agents activate c-Jun N-terminal kinase/stress-activated protein kinase through both Ras and apoptosis signal-regulating kinase pathways. J Biol Chem 273 (1998) 4928-4936
-
(1998)
J Biol Chem
, vol.273
, pp. 4928-4936
-
-
Wang, T.H.1
Wang, H.S.2
Ichijo, H.3
Giannakakou, P.4
Foster, J.S.5
Fojo, T.6
-
18
-
-
33845228689
-
Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine
-
Estève M.A., Carré M., Bourgarel-Rey V., Kruczynski A., Raspaglio G., Ferlini C., et al. Bcl-2 down-regulation and tubulin subtype composition are involved in resistance of ovarian cancer cells to vinflunine. Mol Cancer Ther 5 (2006) 2824-2833
-
(2006)
Mol Cancer Ther
, vol.5
, pp. 2824-2833
-
-
Estève, M.A.1
Carré, M.2
Bourgarel-Rey, V.3
Kruczynski, A.4
Raspaglio, G.5
Ferlini, C.6
-
19
-
-
0035434591
-
Antiangiogenic and antivascular therapy for cancer
-
Taraboletti G., and Margosio B. Antiangiogenic and antivascular therapy for cancer. Curr Opin Pharmacol 1 (2001) 378-384
-
(2001)
Curr Opin Pharmacol
, vol.1
, pp. 378-384
-
-
Taraboletti, G.1
Margosio, B.2
-
20
-
-
30744449235
-
Angiogenesis as a therapeutic target
-
Ferrara N., and Kerbel R.S. Angiogenesis as a therapeutic target. Nature 438 (2005) 967-974
-
(2005)
Nature
, vol.438
, pp. 967-974
-
-
Ferrara, N.1
Kerbel, R.S.2
-
21
-
-
33745249512
-
Microtubule-targeting agents in angiogenesis: where do we stand?
-
Pasquier E., Honoré S., and Braguer D. Microtubule-targeting agents in angiogenesis: where do we stand?. Drug Resist Updat 9 (2006) 74-86
-
(2006)
Drug Resist Updat
, vol.9
, pp. 74-86
-
-
Pasquier, E.1
Honoré, S.2
Braguer, D.3
-
22
-
-
0032762952
-
Antiangiogenesis is produced by nontoxic doses of vinblastine
-
Vacca A., Iurlaro M., Ribatti D., Minischetti M., Nico B., Ria R., et al. Antiangiogenesis is produced by nontoxic doses of vinblastine. Blood 94 (1999) 4143-4155
-
(1999)
Blood
, vol.94
, pp. 4143-4155
-
-
Vacca, A.1
Iurlaro, M.2
Ribatti, D.3
Minischetti, M.4
Nico, B.5
Ria, R.6
-
23
-
-
0029802685
-
The microtubule-affecting drug paclitaxel has antiangiogenic activity
-
Belotti D., Vergani V., Drudis T., Borsotti P., Pitelli M.R., Viale G., et al. The microtubule-affecting drug paclitaxel has antiangiogenic activity. Clin Cancer Res 2 (1996) 1843-1849
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1843-1849
-
-
Belotti, D.1
Vergani, V.2
Drudis, T.3
Borsotti, P.4
Pitelli, M.R.5
Viale, G.6
-
24
-
-
16844381714
-
Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells
-
Pasquier E., Honore S., Pourroy B., Jordan M.A., Lehmann M., Briand C., et al. Antiangiogenic concentrations of paclitaxel induce an increase in microtubule dynamics in endothelial cells but not in cancer cells. Cancer Res 65 (2005) 2433-2440
-
(2005)
Cancer Res
, vol.65
, pp. 2433-2440
-
-
Pasquier, E.1
Honore, S.2
Pourroy, B.3
Jordan, M.A.4
Lehmann, M.5
Briand, C.6
-
25
-
-
33645533966
-
Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells
-
Pourroy B., Honoré S., Pasquier E., Bourgarel-Rey V., Kruczynski A., Briand C., et al. Antiangiogenic concentrations of vinflunine increase the interphase microtubule dynamics and decrease the motility of endothelial cells. Cancer Res 66 (2006) 3256-3263
-
(2006)
Cancer Res
, vol.66
, pp. 3256-3263
-
-
Pourroy, B.1
Honoré, S.2
Pasquier, E.3
Bourgarel-Rey, V.4
Kruczynski, A.5
Briand, C.6
-
26
-
-
33750075041
-
Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development
-
Kruczynski A., Poli M., Dossi R., Chazottes E., Berrichon G., Ricome C., et al. Anti-angiogenic, vascular-disrupting and anti-metastatic activities of vinflunine, the latest vinca alkaloid in clinical development. Eur J Cancer 42 (2006) 2821-2832
-
(2006)
Eur J Cancer
, vol.42
, pp. 2821-2832
-
-
Kruczynski, A.1
Poli, M.2
Dossi, R.3
Chazottes, E.4
Berrichon, G.5
Ricome, C.6
-
27
-
-
0035150786
-
Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model
-
Holwell S.E., Hill B.T., and Bibby M.C. Anti-vascular effects of vinflunine in the MAC 15A transplantable adenocarcinoma model. Br J Cancer 84 (2001) 290-295
-
(2001)
Br J Cancer
, vol.84
, pp. 290-295
-
-
Holwell, S.E.1
Hill, B.T.2
Bibby, M.C.3
-
28
-
-
0034074044
-
In vitro synergistic effects of vinflunine, a novel fluorinated vinca alkaloid, in combination with other anticancer drugs
-
Barret J.M., Etievant C., and Hill B.T. In vitro synergistic effects of vinflunine, a novel fluorinated vinca alkaloid, in combination with other anticancer drugs. Cancer Chemother Pharmacol 45 (2000) 471-476
-
(2000)
Cancer Chemother Pharmacol
, vol.45
, pp. 471-476
-
-
Barret, J.M.1
Etievant, C.2
Hill, B.T.3
-
29
-
-
44449155605
-
Results of a phase I/II and pharmacokinetic study of vinflunine VFL) in combination with cisplatin (CDDP) for primary treatment of advanced non-small cell lung cancer (NSCLC)
-
[abstract 7110]
-
Ramlau R., Souquet P., Sun X., et al. Results of a phase I/II and pharmacokinetic study of vinflunine VFL) in combination with cisplatin (CDDP) for primary treatment of advanced non-small cell lung cancer (NSCLC). [abstract 7110]. J Clin Oncol (Meeting Abstracts) 22 14S (2004) 643s
-
(2004)
J Clin Oncol (Meeting Abstracts)
, vol.22
, Issue.14 S
-
-
Ramlau, R.1
Souquet, P.2
Sun, X.3
-
30
-
-
44449147289
-
-
Souquet P, Ramlau R, Sun X, et al. Vinflunine (VFL) and cisplatin (CDDP) combination in first line treatment of advanced non-small-cell lung cancer (NSCLC). Final results of a phase II study. Paper presented at the World Conference on Lung Cancer; July 3, 2005; Barcelona, Spain. Poster 571.
-
Souquet P, Ramlau R, Sun X, et al. Vinflunine (VFL) and cisplatin (CDDP) combination in first line treatment of advanced non-small-cell lung cancer (NSCLC). Final results of a phase II study. Paper presented at the World Conference on Lung Cancer; July 3, 2005; Barcelona, Spain. Poster 571.
-
-
-
-
31
-
-
44449086184
-
Vinflunine (VFL) in combination with gemcitabine (GEM) for treatment of advanced non-small cell lung cancer (NSCLC) in chemonaive patients (ptd): preliminary results of the phase I and pharmacokinetic study
-
[abstract 7266]
-
Lemarie E., Bennouna J., Grossi F., et al. Vinflunine (VFL) in combination with gemcitabine (GEM) for treatment of advanced non-small cell lung cancer (NSCLC) in chemonaive patients (ptd): preliminary results of the phase I and pharmacokinetic study. [abstract 7266]. J Clin Oncol 23 16S (2005) 686s
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 S
-
-
Lemarie, E.1
Bennouna, J.2
Grossi, F.3
-
32
-
-
41549114752
-
Phase I and pharmacokinetic study of Vinflunine (VFL) in combination with carboplatin (CBDCA) for treatment of advanced non-small cell lung cancer (NSCLC) in chemonaive patients (pts): final results
-
[abstract 7271]
-
Tourani J., Pinel M., Planchard D., Aslanis V., Gouva S., and Robinet G. Phase I and pharmacokinetic study of Vinflunine (VFL) in combination with carboplatin (CBDCA) for treatment of advanced non-small cell lung cancer (NSCLC) in chemonaive patients (pts): final results. [abstract 7271]. J Clin Oncol 23 16S (2005) 688s
-
(2005)
J Clin Oncol
, vol.23
, Issue.16 S
-
-
Tourani, J.1
Pinel, M.2
Planchard, D.3
Aslanis, V.4
Gouva, S.5
Robinet, G.6
-
33
-
-
44449131861
-
-
Campone M, Fumoleau P, Roche H, Bonneterre J, et al. A dose-finding and pharmacokinetic study of IV vinflunine (VFL) in combination with capecitabine (CAPE) as second line treatment of metastatic breast cancer (MBC). Presented at the San Antonio Breast Cancer Symposium; December 14, 2006; San Antonio, TX.
-
Campone M, Fumoleau P, Roche H, Bonneterre J, et al. A dose-finding and pharmacokinetic study of IV vinflunine (VFL) in combination with capecitabine (CAPE) as second line treatment of metastatic breast cancer (MBC). Presented at the San Antonio Breast Cancer Symposium; December 14, 2006; San Antonio, TX.
-
-
-
-
34
-
-
31744449858
-
Development of angiogenesis inhibitors to vascular endothelial growth factor receptor 2. Current status and future perspective
-
Paz K., and Zhu Z. Development of angiogenesis inhibitors to vascular endothelial growth factor receptor 2. Current status and future perspective. Front Biosci 10 (2005) 1415-1439
-
(2005)
Front Biosci
, vol.10
, pp. 1415-1439
-
-
Paz, K.1
Zhu, Z.2
-
35
-
-
33846566408
-
Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu)
-
Reid A., Vidal L., Shaw H., and de B.J. Dual inhibition of ErbB1 (EGFR/HER1) and ErbB2 (HER2/neu). Eur J Cancer 43 (2007) 481-489
-
(2007)
Eur J Cancer
, vol.43
, pp. 481-489
-
-
Reid, A.1
Vidal, L.2
Shaw, H.3
de, B.J.4
-
36
-
-
45349093860
-
Preliminary results of a multicenter phase II trial of vinflunine (with trastuzumab in HER2+ pts) as first-line treatment in metastatic breast cancer
-
[abstract 1043]
-
Peacock N.W., Spigel D.R., Mainwaring P.N., et al. Preliminary results of a multicenter phase II trial of vinflunine (with trastuzumab in HER2+ pts) as first-line treatment in metastatic breast cancer. [abstract 1043]. J Clin Oncol 28 18S (2007) 42s
-
(2007)
J Clin Oncol
, vol.28
, Issue.18 S
-
-
Peacock, N.W.1
Spigel, D.R.2
Mainwaring, P.N.3
-
38
-
-
44449114444
-
-
Catalogue of Somatic Mutations in Cancer (Accessed Dec 19, 2007)
-
Catalogue of Somatic Mutations in Cancer. http://www.sanger.ac.uk/perl/genetics/CGP/cosmic (Accessed Dec 19, 2007)
-
-
-
-
39
-
-
36248943079
-
Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target
-
Knowles M.A. Role of FGFR3 in urothelial cell carcinoma: biomarker and potential therapeutic target. World J Urol 25 (2007) 581-593
-
(2007)
World J Urol
, vol.25
, pp. 581-593
-
-
Knowles, M.A.1
-
40
-
-
33646473687
-
Cell cycle effects of vinflunine, the most recent promising Vinca alkaloid, and its interaction with radiation, in vitro
-
Simoens C., Vermorken J.B., Korst A.E., et al. Cell cycle effects of vinflunine, the most recent promising Vinca alkaloid, and its interaction with radiation, in vitro. Cancer Chemother Pharmacol 58 (2006) 210-218
-
(2006)
Cancer Chemother Pharmacol
, vol.58
, pp. 210-218
-
-
Simoens, C.1
Vermorken, J.B.2
Korst, A.E.3
-
41
-
-
43749085592
-
Further mechanistic unraveling of the influence of the cell cycle effects on the radiosensitising mechanism of vinflunine, in vitro
-
In press
-
Simoens C., Pauwels B., Vermorken J.B., Patyn G.G., Lambreckts H.A., Breillout F., et al. Further mechanistic unraveling of the influence of the cell cycle effects on the radiosensitising mechanism of vinflunine, in vitro. Cancer Chemother Pharmacol (2008) In press
-
(2008)
Cancer Chemother Pharmacol
-
-
Simoens, C.1
Pauwels, B.2
Vermorken, J.B.3
Patyn, G.G.4
Lambreckts, H.A.5
Breillout, F.6
-
42
-
-
0019818819
-
Preclinical drug development: Rationale and methods
-
Venditti J.M. Preclinical drug development: Rationale and methods. Semin Oncol 8 (1981) 349-361
-
(1981)
Semin Oncol
, vol.8
, pp. 349-361
-
-
Venditti, J.M.1
|