Pyridinium cationic-dimer antimalarials, unlike chloroquine, act selectively between the schizont stage and the ring stage of Plasmodium falciparum

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 11, 2008, Pages 6027-6033

  Yoshikawa, Mai ^a   Motoshima, Kazunori ^a   Fujimoto, Kanji ^a   Tai, Akihiro ^a   Kakuta, Hiroki ^a   Sasaki, Kenji ^a  

^a OKAYAMA UNIVERSITY   (Japan)

Author keywords

Antimalarials; Cationic dimer; Hammett's ; Hansch Fujita ; Synchronized culture

Indexed keywords

1,1' (1,10 DECANEDIYL)BIS[4 [(HEXYLAMINO)CARBONYL]PYRIDINIUM BROMIDE]; 1,1' (1,10 DECANEDIYL)BIS[4 [(PHENYLAMINO)CARBONYL]PYRIDINIUM BROMIDE]; ANTIMALARIAL AGENT; CHLOROQUINE; MAP 610; PHENYL GROUP; PMAP H10; PYRIDINIUM DERIVATIVE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG STRUCTURE; GROWTH INHIBITION; HYDROPHOBICITY; IN VITRO STUDY; MAMMAL CELL; NONHUMAN; PLASMODIUM FALCIPARUM; SCHIZONT;

ANIMALS; ANTIMALARIALS; CATIONS; CELL LINE, TUMOR; CHLOROQUINE; DIMERIZATION; DRUG RESISTANCE; ERYTHROCYTES; HUMANS; INHIBITORY CONCENTRATION 50; MICE; PARASITEMIA; PLASMODIUM FALCIPARUM; PYRIDINIUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

PLASMODIUM FALCIPARUM;

EID: 44449104165     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.04.051     Document Type: Article

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