Whole-brain glutamate metabolism evaluated by steady-state kinetics using a double-isotope procedure: Effects of gabapentin

Journal of Neurochemistry

Volumn 90, Issue 5, 2004, Pages 1104-1116

  Xu, Y ^a   Oz G ^b   LaNoue, Kathryn F ^a,d   Keiger, C J ^c   Berkich, D A ^a   Gruetter, R ^b   Hutson, S H ^c  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d Cellular and Molecular Physiology   (United States)

Author keywords

Brain; Gabapentin; Glutamate glutamine cycle; Glutamatergic neurons; Pyruvate carboxylase; Retina

Indexed keywords

BICARBONATE; BRAIN EXTRACT; BRANCHED CHAIN AMINO ACID AMINOTRANSFERASE; CARBON 13; GABAPENTIN; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; PYRUVATE CARBOXYLASE; TRACER;

AMINO ACID METABOLISM; AMINO ACID SYNTHESIS; AMINO ACID TRANSPORT; ANAPLEROSIS; ANIMAL TISSUE; ARTICLE; BRAIN METABOLISM; CONTROLLED STUDY; DOUBLE ISOTOPE LABELING; DRUG EFFECT; GLIA; GLUTAMATE GLUTAMINE CYCLE; GLUTAMATE METABOLISM; GLUTAMATERGIC NERVE CELL; ISOTOPE LABELING; MALE; METABOLISM; NERVE CELL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; RETINA; STEADY STATE;

ACETIC ACIDS; AMINES; ANIMALS; ASTROCYTES; BICARBONATES; BRAIN; BRAIN CHEMISTRY; CARBON ISOTOPES; CHROMATOGRAPHY; CYCLOHEXANECARBOXYLIC ACIDS; EXCITATORY AMINO ACID ANTAGONISTS; GAMMA-AMINOBUTYRIC ACID; GLUCOSE; GLUTAMIC ACID; GLUTAMINE; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MODELS, NEUROLOGICAL; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS; RETINA; TIME FACTORS;

ANIMALIA;

EID: 4444383119     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02576.x     Document Type: Article

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