Determination and pharmacokinetic profile of pyrazinamide in rat blood, brain and bile using microdialysis coupled with high-performance liquid chromatography and verified by tandem mass spectrometry

Analytica Chimica Acta

Volumn 522, Issue 2, 2004, Pages 231-239

  Wu, Jhy Wen ^a,b   Shih, Hsin Hui ^c   Wang, Shau Chun ^c   Tsai, Tung Hu ^a,d,e  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CENTER FOR DISEASE CONTROL   (Taiwan)

^c NATIONAL CHUNG CHENG UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

Author keywords

Hepatobiliary excretion; Liquid chromatography tandem mass; Microdialysis; Pharmacokinetics; Pyrazinamide

Indexed keywords

BIOLOGICAL FLUIDS; MICRODIALYSIS; MOBILE PHASES;

BLOOD; BRAIN; DIALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHARMACOKINETICS;

AMINES;

PYRAZINAMIDE;

ANIMAL EXPERIMENT; ARTICLE; BILE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DETERMINATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

EID: 4444376068     PISSN: 00032670     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.aca.2004.06.004     Document Type: Article

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