Effect of substrate exposure and other growth condition manipulations on norA expression

Journal of Antimicrobial Chemotherapy

Volumn 54, Issue 2, 2004, Pages 364-369

  Kaatz, Glenn W ^a   Seo, Susan M ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Efflux; Regulation; Staphylococcus

Indexed keywords

ACRIDINE ORANGE; BENZALKONIUM CHLORIDE; BETA GALACTOSIDASE; CARRIER PROTEIN; CETRIMIDE; ETHIDIUM BROMIDE; HYBRID PROTEIN; MESSENGER RNA; NORA PROTEIN; NORFLOXACIN; REGULATOR PROTEIN; SALICYLIC ACID; SODIUM CHLORIDE; TETRACYCLINE; TETRAPHENYLPHOSPHONIUM; UNCLASSIFIED DRUG;

ANTIBIOTIC SENSITIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL CHROMOSOME; BACTERIAL GROWTH; CONTROLLED STUDY; DRUG TRANSPORT; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; GENE LOCUS; GENETIC TRANSCRIPTION; HALF LIFE TIME; MULTIDRUG RESISTANCE; NONHUMAN; OSMOTIC STRESS; PROTEIN PROTEIN INTERACTION; QUANTITATIVE ANALYSIS; STAPHYLOCOCCUS AUREUS; TEMPERATURE MEASUREMENT; TRANSLATION REGULATION;

ANTI-INFECTIVE AGENTS, LOCAL; ARTIFICIAL GENE FUSION; BACTERIAL PROTEINS; BENZALKONIUM COMPOUNDS; BETA-GALACTOSIDASE; CHROMOSOMES, BACTERIAL; CULTURE MEDIA; DRUG RESISTANCE, MULTIPLE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; HALF-LIFE; INDICATORS AND REAGENTS; LAC OPERON; MICROBIAL SENSITIVITY TESTS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RNA, BACTERIAL; RNA, MESSENGER; SALICYLATES; STAPHYLOCOCCUS AUREUS; TEMPERATURE;

EID: 4444327371     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/dkh341     Document Type: Article

References (32)

1. Van Bambeke, F., Glupczynski, Y., Plesiat, P. et al. (2003). Antibiotic efflux pumps in prokaryotic cells: occurrence, impact on resistance and strategies for the future of antimicrobial therapy. Journal of Antimicrobial Chemotherapy 51, 313-38.
2. Lee, A., Mao, W., Warren, M. S. et al. (2000). Interplay between efflux pumps may provide either additive or multiplicative effects on drug resistance. Journal of Bacteriology 182, 3142-50.
3. Ubukata, K., Itoh-Yamashita, N. & Konno, M. (1989). Cloning and expression of the norA gene for fluoroquinolone resistance in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 33, 1535-9.
4. Neyfakh, A. A., Borsch, C. M. & Kaatz, G. W. (1993). Fluoroquinolone resistance protein NorA of Staphylococcus aureus is a multidrug efflux transporter. Antimicrobial Agents and Chemotherapy 37, 128-9.
5. Ng, E. Y., Trucksis, M. & Hooper, D. C. (1994). Quinolone resistance mediated by norA: physiologic characterization and relationship to flqB, a quinolone resistance locus on the Staphylococcus aureus chromosome. Antimicrobial Agents and Chemotherapy 38, 1345-55.
6. Yu, J.-L., Grinius, L. & Hooper, D. C. (2002). NorA functions as a multidrug efflux protein in both cytoplasmic membrane vesicles and reconstituted proteoliposomes. Journal of Bacteriology 184, 1370-7.
7. Kaatz, G. W. & Seo, S. M. (1995). Inducible NorA-mediated multidrug resistance in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 39, 2650-5.
8. Kaatz, G. W., Seo, S. M. & Ruble, C. A. (1993). Efflux-mediated fluoroquinolone resistance in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 37, 1086-94.
9. Neyfakh, A. A., Bidnenko, V. E. & Chen, L. B. (1991). Efflux-mediated multidrug resistance in Bacillus subtilis: similarities and dissimilarities with the mammalian system. Proceedings of the National Academy of Sciences USA 88, 4781-5.
10. Neyfakh, A. A. (1992). The multidrug efflux transporter of Bacillus subtilis is a structural and functional homologue of the Staphylococcus aureus NorA protein. Antimicrobial Agents and Chemotherapy 36, 484-5.
11. Ahmed, M., Borsch, C. M., Taylor, S. S. et al. (1994). A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. Journal of Biological Chemistry 269, 1-8.
12. Zheleznova, E. E., Markham, P. M., Neyfakh, A. A. et al. (1999). Structural basis of multidrug recognition by BmrR, a transcriptional activator of a multidrug transporter. Cell 96, 353-62.
13. Ahmed, M., Lyass, L., Markham, P. M. et al. (1995). Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. Journal of Bacteriology 177, 3904-10.
14. Paulsen, I. T., Brown, M. H., Littlejohn, T. G. et al. (1996). Multidrug resistance proteins QacA and QacB from Staphylococcus aureus: membrane topology and identification of residues involved in substrate specificity. Proceedings of the National Academy of Sciences USA 93, 3630-5.
15. Grkovic, S., Brown, M. H. & Skurray, R. A. (2002). Regulation of bacterial drug export systems. Microbiology and Molecular Biology Reviews 66, 671-701.
16. Fournier, B., Aras, R. & Hooper, D. C. (2000). Expression of the multidrug resistance transporter NorA from Staphylococcus aureus is modified by a two-component regulatory system. Journal of Bacteriology 182, 664-71.
17. Fournier, B. & Hooper, D. C. (2000). A new two-component regulatory system involved in adhesion, autolysis, and extracellular proteolytic activity of Staphylococcus aureus. Journal of Bacteriology 182, 3955-64.
18. Truong-Boldoc, Q.-C., Zhang, X. & Hooper, D. C. (2003). Characterization of NorR protein, a multifunctional regulator of norA expression in Staphylococcus aureus. Journal of Bacteriology 185, 3127-38.
19. Trucksis, M., Wolfson, J. S. & Hooper, D. C. (1991). A novel locus conferring fluoroquinolone resistance in Staphylococcus aureus. Journal of Bacteriology 173, 5854-60.
20. Ingavale, S. S., Van Wamel, W. & Cheung, A. C. (2003). Characterization of Rat, an autolysis regulator in Staphylococcus aureus. Molecular Microbiology 48, 1451-66.
21. Luong, T. T., Newell, S. W. & Lee, C. Y. (2003). mgr, a novel global regulator in Staphylococcus aureus. Journal of Bacteriology 185, 3703-10.
22. Kreiswirth, B. N., Lofdahl, M. S., Betley, M. J. et al. (1983). The toxic shock syndrome exotoxin structural gene is not detectably transmitted by prophage. Nature 305, 709-12.
23. Horsburgh, M. J., Aish, J. L., White, I. J. et al. (2002). sB modulates virulence determinant expression and stress resistance: characterization of a functional rsbU strain derived from Staphylococcus aureus 8325-4. Journal of Bacteriology 184, 5457-67.
24. B in Staphylococcus aureus reveals its function as a global regulator of virulence genes. Journal of Bacteriology 180, 4814-20.
25. National Committee for Clinical Laboratory Standards. (1999). Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria that Grow Aerobically - Fifth Edition: Approved Standard M7-A5. NCCLS, Wayne, PA, USA.
26. Kemp, E. H., Sammons, R. L., Moir, A. et al. (1991). Analysis of transcriptional control of the gerD spore germination gene of Bacillus subtilis 168. Journal of Bacteriology 173, 4646-52.
27. McAleese, F. M., Walsh, E. J., Sieprawska, M. et al. (2001). Loss of clumping factor B fibrinogen binding activity by Staphylococcus aureus involves cessation of transcription, shedding and cleavage by metalloprotease. Journal of Biological Chemistry 278, 29969-78.
28. Price, C. T., Lee, I. R. & Gustafson, J. E. (2000). The effects of salicylate on bacteria. International Journal of Biochemistry and Cell Biology 32, 1029-43.
29. Price, C. T., Kaatz, G. W. & Gustafson, J. E. (2002). The multidrug efflux pump NorA is not required for salicylate-induced reduction in drug accumulation by Staphylococcus aureus. International Journal of Antimicrobial Agents 20, 206-13.
30. Lim, H. M., Lewis, D. E. A., Lee, H. J. et al. (2003). Effect of varying the supercoiling of DNA on transcription and its regulation. Biochemistry 42, 10718-25.
31. Afonyushkin, T., Moll, I., Bläsi, U. et al. (2002). Temperature-dependent stability and translation of Escherichia coli ompA mRNA. Biochemical and Biophysical Research Communications 311, 604-9.
32. Craig, D. B., Nachtigall, J. T., Ash, H. L. et al. (2003). Differences in the average single molecule activities of E. coli β-galactosidase: effect of source, enzyme molecule age and temperature of induction. Journal of Protein Science 22, 555-61.