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Volumn 327, Issue 2, 2004, Pages 206-214

Characterization of a nuclear localization signal in the C-terminus of the adeno-associated virus Rep68/78 proteins

Author keywords

Adeno associated virus (AAV); NLS; Rep protein

Indexed keywords

PROTEIN REP68; PROTEIN REP78; UNCLASSIFIED DRUG; VIRUS PROTEIN;

EID: 4444284261     PISSN: 00426822     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.virol.2004.06.034     Document Type: Article
Times cited : (18)

References (36)
  • 1
    • 0033952245 scopus 로고    scopus 로고
    • A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay
    • T. Cathomen, D. Collette, and M.D. Weitzman A chimeric protein containing the N terminus of the adeno-associated virus Rep protein recognizes its target site in an in vivo assay J. Virol. 74 2000 2372 2382
    • (2000) J. Virol. , vol.74 , pp. 2372-2382
    • Cathomen, T.1    Collette, D.2    Weitzman, M.D.3
  • 2
    • 0028107265 scopus 로고
    • Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli
    • J.A. Chiorini, M.D. Weitzman, R.A. Owens, E. Urcelay, B. Safer, and R.M. Kotin Biologically active Rep proteins of adeno-associated virus type 2 produced as fusion proteins in Escherichia coli J. Virol. 68 2 1994 797 804
    • (1994) J. Virol. , vol.68 , Issue.2 , pp. 797-804
    • Chiorini, J.A.1    Weitzman, M.D.2    Owens, R.A.3    Urcelay, E.4    Safer, B.5    Kotin, R.M.6
  • 3
    • 0030868737 scopus 로고    scopus 로고
    • High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression
    • E. Costello, P. Saudan, E. Winocour, L. Pizer, and P. Beard High mobility group chromosomal protein 1 binds to the adeno-associated virus replication protein (Rep) and promotes Rep-mediated site-specific cleavage of DNA, ATPase activity and transcriptional repression EMBO J. 16 19 1997 5943 5954
    • (1997) EMBO J. , vol.16 , Issue.19 , pp. 5943-5954
    • Costello, E.1    Saudan, P.2    Winocour, E.3    Pizer, L.4    Beard, P.5
  • 4
    • 0035875067 scopus 로고    scopus 로고
    • Journey to the center of the cell
    • B.R. Cullen Journey to the center of the cell Cell 105 6 2001 697 700
    • (2001) Cell , vol.105 , Issue.6 , pp. 697-700
    • Cullen, B.R.1
  • 5
    • 0033052212 scopus 로고    scopus 로고
    • Analysis of the effects of charge cluster mutations in adeno-associated virus rep68 protein in vitro
    • M.D. Davis, R.S. Wonderling, S.L. Walker, and R.A. Owens Analysis of the effects of charge cluster mutations in adeno-associated virus rep68 protein in vitro J. Virol. 73 3 1999 2084 2093
    • (1999) J. Virol. , vol.73 , Issue.3 , pp. 2084-2093
    • Davis, M.D.1    Wonderling, R.S.2    Walker, S.L.3    Owens, R.A.4
  • 6
    • 0034004021 scopus 로고    scopus 로고
    • Mutational analysis of adeno-associated virus type 2 Rep68 protein endonuclease activity on partially single-stranded substrates
    • M.D. Davis, J. Wu, and R.A. Owens Mutational analysis of adeno-associated virus type 2 Rep68 protein endonuclease activity on partially single-stranded substrates J. Virol. 74 6 2000 2936 2942
    • (2000) J. Virol. , vol.74 , Issue.6 , pp. 2936-2942
    • Davis, M.D.1    Wu, J.2    Owens, R.A.3
  • 7
    • 0032826095 scopus 로고    scopus 로고
    • Adeno-associated virus type 2 protein interactions: Formation of pre-encapsidation complexes
    • R. Dubielzig, J.A. King, S. Weger, A. Kern, and J.A. Kleinschmidt Adeno-associated virus type 2 protein interactions: formation of pre-encapsidation complexes J. Virol. 73 11 1999 8989 8998
    • (1999) J. Virol. , vol.73 , Issue.11 , pp. 8989-8998
    • Dubielzig, R.1    King, J.A.2    Weger, S.3    Kern, A.4    Kleinschmidt, J.A.5
  • 8
    • 0029841689 scopus 로고    scopus 로고
    • The adeno-associated virus Rep78 major regulatory/transformation suppressor protein binds cellular Sp1 in vitro and evidence of a biological effect
    • P.L. Hermonat, A.D. Santin, and R.B. Batchu The adeno-associated virus Rep78 major regulatory/transformation suppressor protein binds cellular Sp1 in vitro and evidence of a biological effect Cancer Res. 56 22 1996 5299 5304
    • (1996) Cancer Res. , vol.56 , Issue.22 , pp. 5299-5304
    • Hermonat, P.L.1    Santin, A.D.2    Batchu, R.B.3
  • 9
    • 0026501651 scopus 로고
    • Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells
    • L.A. Hunter, and R.J. Samulski Colocalization of adeno-associated virus Rep and capsid proteins in the nuclei of infected cells J. Virol. 66 1 1992 317 324
    • (1992) J. Virol. , vol.66 , Issue.1 , pp. 317-324
    • Hunter, L.A.1    Samulski, R.J.2
  • 10
    • 0025362618 scopus 로고
    • The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity
    • D.S. Im, and N. Muzyczka The AAV origin binding protein Rep68 is an ATP-dependent site-specific endonuclease with DNA helicase activity Cell 61 3 1990 447 457
    • (1990) Cell , vol.61 , Issue.3 , pp. 447-457
    • Im, D.S.1    Muzyczka, N.2
  • 11
    • 0026597463 scopus 로고
    • Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization
    • D.S. Im, and N. Muzyczka Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization J. Virol. 66 2 1992 1119 1128
    • (1992) J. Virol. , vol.66 , Issue.2 , pp. 1119-1128
    • Im, D.S.1    Muzyczka, N.2
  • 12
    • 0031785929 scopus 로고    scopus 로고
    • How do animal DNA viruses get to the nucleus?
    • H. Kasamatsu, and A. Nakanishi How do animal DNA viruses get to the nucleus? Annu. Rev. Microbiol. 52 1998 627 686
    • (1998) Annu. Rev. Microbiol. , vol.52 , pp. 627-686
    • Kasamatsu, H.1    Nakanishi, A.2
  • 13
    • 0031583848 scopus 로고    scopus 로고
    • An imperfect correlation between DNA replication activity of Epsteinâ€"Barr virus nuclear antigen 1 (EBNA1) and binding to the nuclear import receptor, Rch1/importin alpha
    • A.L. Kim, M. Maher, J.B. Hayman, J. Ozer, D. Zerby, J.L. Yates, and P.M. Lieberman An imperfect correlation between DNA replication activity of Epsteinâ€"Barr virus nuclear antigen 1 (EBNA1) and binding to the nuclear import receptor, Rch1/importin alpha Virology 239 2 1997 340 351
    • (1997) Virology , vol.239 , Issue.2 , pp. 340-351
    • Kim, A.L.1    Maher, M.2    Hayman, J.B.3    Ozer, J.4    Zerby, D.5    Yates, J.L.6    Lieberman, P.M.7
  • 14
    • 0036311953 scopus 로고    scopus 로고
    • Studies of the mechanism of transactivation of the adeno-associated virus p19 promoter by Rep protein
    • D.F. Lackner, and N. Muzyczka Studies of the mechanism of transactivation of the adeno-associated virus p19 promoter by Rep protein J. Virol. 76 16 2002 8225 8235
    • (2002) J. Virol. , vol.76 , Issue.16 , pp. 8225-8235
    • Lackner, D.F.1    Muzyczka, N.2
  • 15
    • 0041885527 scopus 로고    scopus 로고
    • Characterization of the adenoassociated virus Rep protein complex formed on the viral origin of DNA replication
    • Z. Li, J.R. Brister, D.S. Im, and N. Muzyczka Characterization of the adenoassociated virus Rep protein complex formed on the viral origin of DNA replication Virology 313 2 2003 364 376
    • (2003) Virology , vol.313 , Issue.2 , pp. 364-376
    • Li, Z.1    Brister, J.R.2    Im, D.S.3    Muzyczka, N.4
  • 16
    • 0037333846 scopus 로고    scopus 로고
    • A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway
    • P. Lischka, G. Sorg, M. Kann, M. Winkler, and T. Stamminger A nonconventional nuclear localization signal within the UL84 protein of human cytomegalovirus mediates nuclear import via the importin alpha/beta pathway J. Virol. 77 6 2003 3734 3748
    • (2003) J. Virol. , vol.77 , Issue.6 , pp. 3734-3748
    • Lischka, P.1    Sorg, G.2    Kann, M.3    Winkler, M.4    Stamminger, T.5
  • 17
    • 0035203632 scopus 로고    scopus 로고
    • Transport into and out of the nucleus
    • I.G. Macara Transport into and out of the nucleus Microbiol. Mol. Biol. Rev. 65 4 2001 570 594 (table of contents)
    • (2001) Microbiol. Mol. Biol. Rev. , vol.65 , Issue.4 , pp. 570-594
    • MacAra, I.G.1
  • 18
    • 0026659844 scopus 로고
    • Analysis of mutations in adeno-associated virus Rep protein in vivo and in vitro
    • D.M. McCarty, T.H. Ni, and N. Muzyczka Analysis of mutations in adeno-associated virus Rep protein in vivo and in vitro J. Virol. 66 7 1992 4050 4057
    • (1992) J. Virol. , vol.66 , Issue.7 , pp. 4050-4057
    • McCarty, D.M.1    Ni, T.H.2    Muzyczka, N.3
  • 19
    • 0028290387 scopus 로고
    • Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein
    • D.M. McCarty, D.J. Pereira, I. Zolotukhin, X. Zhou, J.H. Ryan, and N. Muzyczka Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein J. Virol. 68 8 1994 4988 4997
    • (1994) J. Virol. , vol.68 , Issue.8 , pp. 4988-4997
    • McCarty, D.M.1    Pereira, D.J.2    Zolotukhin, I.3    Zhou, X.4    Ryan, J.H.5    Muzyczka, N.6
  • 20
    • 0028338651 scopus 로고
    • Interaction of the adeno-associated virus Rep protein with a sequence within the a palindrome of the viral terminal repeat
    • D.M. McCarty, J.H. Ryan, S. Zolotukhin, X. Zhou, and N. Muzyczka Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat J. Virol. 68 8 1994 4998 5006
    • (1994) J. Virol. , vol.68 , Issue.8 , pp. 4998-5006
    • McCarty, D.M.1    Ryan, J.H.2    Zolotukhin, S.3    Zhou, X.4    Muzyczka, N.5
  • 21
    • 0001142644 scopus 로고    scopus 로고
    • Parvoviridae: The viruses and their replication
    • D.M. Knipe P.M. Howley 4th ed. Lippincott Williams and Wilkins Philadelpia, PA
    • N. Muzyczka, and K.I. Berns Parvoviridae: the viruses and their replication D.M. Knipe P.M. Howley 4th ed. Fields Virology vol. 2 2001 Lippincott Williams and Wilkins Philadelpia, PA 2327 2359
    • (2001) Fields Virology , vol.2 , pp. 2327-2359
    • Muzyczka, N.1    Berns, K.I.2
  • 22
    • 0027496233 scopus 로고
    • Nuclear targeting of the parvoviral replicator molecule NS1: Evidence for self-association prior to nuclear transport
    • J.P. Nuesch, and P. Tattersall Nuclear targeting of the parvoviral replicator molecule NS1: evidence for self-association prior to nuclear transport Virology 196 2 1993 637 651
    • (1993) Virology , vol.196 , Issue.2 , pp. 637-651
    • Nuesch, J.P.1    Tattersall, P.2
  • 23
    • 0027476207 scopus 로고
    • Identification of a DNA-binding domain in the amino terminus of adeno-associated virus Rep proteins
    • R.A. Owens, M.D. Weitzman, S.R. Kyostio, and B.J. Carter Identification of a DNA-binding domain in the amino terminus of adeno-associated virus Rep proteins J. Virol. 67 2 1993 997 1005
    • (1993) J. Virol. , vol.67 , Issue.2 , pp. 997-1005
    • Owens, R.A.1    Weitzman, M.D.2    Kyostio, S.R.3    Carter, B.J.4
  • 24
    • 0031048047 scopus 로고    scopus 로고
    • The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter
    • D.J. Pereira, and N. Muzyczka The cellular transcription factor SP1 and an unknown cellular protein are required to mediate Rep protein activation of the adeno-associated virus p19 promoter J. Virol. 71 3 1997 1747 1756
    • (1997) J. Virol. , vol.71 , Issue.3 , pp. 1747-1756
    • Pereira, D.J.1    Muzyczka, N.2
  • 25
    • 0042121451 scopus 로고    scopus 로고
    • A non-canonical transferable signal mediates nuclear import of simian immunodeficiency virus Vpx protein
    • P. Rajendra Kumar, P.K. Singhal, S.S. Vinod, and S. Mahalingam A non-canonical transferable signal mediates nuclear import of simian immunodeficiency virus Vpx protein J. Mol. Biol. 331 5 2003 1141 1156
    • (2003) J. Mol. Biol. , vol.331 , Issue.5 , pp. 1141-1156
    • Rajendra Kumar, P.1    Singhal, P.K.2    Vinod, S.S.3    Mahalingam, S.4
  • 26
    • 0024311525 scopus 로고
    • Helper-free stocks of recombinant adeno-associated viruses: Normal integration does not require viral gene expression
    • R.J. Samulski, L.S. Chang, and T. Shenk Helper-free stocks of recombinant adeno-associated viruses: normal integration does not require viral gene expression J. Virol. 63 1989 3822 3828
    • (1989) J. Virol. , vol.63 , pp. 3822-3828
    • Samulski, R.J.1    Chang, L.S.2    Shenk, T.3
  • 27
    • 0030947409 scopus 로고    scopus 로고
    • The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences
    • R.H. Smith, A.J. Spano, and R.M. Kotin The Rep78 gene product of adeno-associated virus (AAV) self-associates to form a hexameric complex in the presence of AAV ori sequences J. Virol. 71 6 1997 4461 4471
    • (1997) J. Virol. , vol.71 , Issue.6 , pp. 4461-4471
    • Smith, R.H.1    Spano, A.J.2    Kotin, R.M.3
  • 29
    • 0030846525 scopus 로고    scopus 로고
    • Mutational analysis of the adeno-associated virus type 2 Rep68 protein helicase motifs
    • S.L. Walker, R.S. Wonderling, and R.A. Owens Mutational analysis of the adeno-associated virus type 2 Rep68 protein helicase motifs J. Virol. 71 9 1997 6996 7004
    • (1997) J. Virol. , vol.71 , Issue.9 , pp. 6996-7004
    • Walker, S.L.1    Wonderling, R.S.2    Owens, R.A.3
  • 30
    • 0030058330 scopus 로고    scopus 로고
    • Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers
    • M.D. Weitzman, K.J. Fisher, and J.M. Wilson Recruitment of wild-type and recombinant adeno-associated virus into adenovirus replication centers J. Virol. 70 3 1996 1845 1854
    • (1996) J. Virol. , vol.70 , Issue.3 , pp. 1845-1854
    • Weitzman, M.D.1    Fisher, K.J.2    Wilson, J.M.3
  • 31
    • 0029869445 scopus 로고    scopus 로고
    • Interaction of wild-type and mutant adeno-associated virus (AAV) Rep proteins on AAV hairpin DNA
    • M.D. Weitzman, S.R. Kyostio, B.J. Carter, and R.A. Owens Interaction of wild-type and mutant adeno-associated virus (AAV) Rep proteins on AAV hairpin DNA J. Virol. 70 4 1996 2440 2448
    • (1996) J. Virol. , vol.70 , Issue.4 , pp. 2440-2448
    • Weitzman, M.D.1    Kyostio, S.R.2    Carter, B.J.3    Owens, R.A.4
  • 32
    • 0031015285 scopus 로고    scopus 로고
    • Subcellular compartmentalization of adeno-associated virus type 2 assembly
    • A. Wistuba, A. Kern, S. Weger, D. Grimm, and J.A. Kleinschmidt Subcellular compartmentalization of adeno-associated virus type 2 assembly J. Virol. 71 2 1997 1341 1352
    • (1997) J. Virol. , vol.71 , Issue.2 , pp. 1341-1352
    • Wistuba, A.1    Kern, A.2    Weger, S.3    Grimm, D.4    Kleinschmidt, J.A.5
  • 33
    • 0036828086 scopus 로고    scopus 로고
    • Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2
    • W. Xiao, K.H. Warrington Jr., P. Hearing, J. Hughes, and N. Muzyczka Adenovirus-facilitated nuclear translocation of adeno-associated virus type 2 J. Virol. 76 22 2002 11505 11517
    • (2002) J. Virol. , vol.76 , Issue.22 , pp. 11505-11517
    • Xiao, W.1    Warrington Jr., K.H.2    Hearing, P.3    Hughes, J.4    Muzyczka, N.5
  • 34
    • 0027241589 scopus 로고
    • Analysis of the terminal repeat binding abilities of mutant adeno-associated virus replication proteins
    • Q. Yang, and J.P. Trempe Analysis of the terminal repeat binding abilities of mutant adeno-associated virus replication proteins J. Virol. 67 7 1993 4442 4447
    • (1993) J. Virol. , vol.67 , Issue.7 , pp. 4442-4447
    • Yang, Q.1    Trempe, J.P.2
  • 35
    • 0026731015 scopus 로고
    • Mutational analysis of the adeno-associated virus rep gene
    • Q. Yang, A. Kadam, and J.P. Trempe Mutational analysis of the adeno-associated virus rep gene J. Virol. 66 10 1992 6058 6069
    • (1992) J. Virol. , vol.66 , Issue.10 , pp. 6058-6069
    • Yang, Q.1    Kadam, A.2    Trempe, J.P.3
  • 36
    • 0035106817 scopus 로고    scopus 로고
    • Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro
    • M. Yoon, D.H. Smith, P. Ward, F.J. Medrano, A.K. Aggarwal, and R.M. Linden Amino-terminal domain exchange redirects origin-specific interactions of adeno-associated virus rep78 in vitro J. Virol. 75 7 2001 3230 3239
    • (2001) J. Virol. , vol.75 , Issue.7 , pp. 3230-3239
    • Yoon, M.1    Smith, D.H.2    Ward, P.3    Medrano, F.J.4    Aggarwal, A.K.5    Linden, R.M.6


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