The adeno-associated virus Rep78 major regulatory/transformation suppressor protein binds cellular Sp1 in vitro and evidence of a biological effect

Cancer Research

Volumn 56, Issue 22, 1996, Pages 5299-5304

  Hermonat, Paul L ^a   Santin, Alessandro D ^a,b   Batchu, Ramesh B ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS; ARTICLE; DNA REPLICATION; DNA SYNTHESIS INHIBITION; ELECTROPHORETIC MOBILITY; GENETIC REGULATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MALIGNANT TRANSFORMATION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTO ONCOGENE; TRANSCRIPTION INITIATION;

ANIMALS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA; DNA-BINDING PROTEINS; HELA CELLS; HUMANS; MICE; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); SP1 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSCRIPTION, GENETIC; TRANSFECTION; VIRAL PROTEINS;

EID: 0029841689     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. Snyder, R. O., Im, D. S., Ni, T., Xiao, X., Samulski, R. J., and Muzyczka, N. Features of the adeno-associated virus origin involved in substrate recognition by the viral rep protein. J Virol., 67: 6096-6104, 1993.
2. Im, D. S., and Muzyczka, N. Factors that bind to adeno-associated virus terminal repeats J. Virol., 63: 3095-3104, 1989.
3. Im, D. S., and Muzyczka, N. Partial purification of adeno-associated virus Rep78, Rep52, and Rep40 and their biochemical characterization. J Virol., 66: 1119-1128, 1992.
4. Im, D. S., and Muzyczka, N. The AAV origin binding protein Rep68 is an ATP-dependent site-specific endo-nuclease with DNA helicase activity. Cell, 61: 447-457, 1990.
5. Batchu, R. B., Miles, D. A., Rectin, T. M., Drake, R. R., and Hermonat, P. L. Cloning, expression and purification of full length Rep78 of adeno-associated virus as a fusion protein with maltose binding protein in Escherichia coli. Biochem. Biophys Res Commun., 208: 714-720, 1995.
6. Hermonat, P. L., Labow, M. A., Wright, R., Berns, K. I., and Muzyczka, N. Genetics of adeno-associated virus: isolation and preliminary characterization of adeno-associated virus type 2 mutants. J. Virol., 51: 329-339, 1984.
7. Tratschin, J. D., Miller, I. L., and Carter, B. J. Genetic analysis of adeno-associated virus: properties of deletion mutants constructed in vitro and evidence for an adeno-associated virus replication function. J Virol., 51: 611-619, 1984.
8. Labow, M. A., Hermonat, P. L., and Berns, K. I. Positive and negative autoregulation of the adeno-associated virus type 2 genome J. Virol., 60: 251-258, 1986.
9. Tratschin, J. D., Tal, J., and Carter, B. J. Negative and positive regulation in trans of gene expression from adeno-associated virus vectors in mammalian cells by a viral rep gene product. Mol. Cell Biol., 6: 2884-2894, 1986.
10. Katz, E., and Carter, B. J. Effect of adeno-associated virus on transformation of NIH 3T3 cells by ras gene and on tumorigenicity of an NIH 3T3 transformed cell line. Cancer Res., 46: 3023-3026, 1986.
11. Hermonat, P. L. Inhibition of H-ras expression by the adeno-associated virus Rep78 transformation suppressor gene product Cancer Res., 51, 3373-3377, 1991
12. Klein-Bauernschmitt, P., zur Hausen, H., and Schlehofer, J. R. Induction of differentiation-associated changes in established human cells by infection with adeno-associated virus type 2 J. Virol., 66: 4191-4200, 1992.
13. Hermonat, P. L. Down regulation of the human c-fos and c-myc proto-oncogene promoters by adeno-associated virus Rep78. Cancer Lett., 81: 129-136, 1994.
14. Batchu, B. R., Kotin, R. M., and Hermonat, P. L. The regulatory rep protein of adeno-associated virus binds to sequences within the c-H-ras promoter. Cancer Lett., 86: 23-31, 1994.
15. Labow, M. A., Graf, L. H., and Berns, K. I. Adeno-associated virus gene expression inhibits cellular transformation by heterologous genes. Mol. Cell Biol., 7 1320-1325, 1987
16. Hermonat, P. L. The adeno-associated virus Rep78 gene inhibits cellular transformation induced by bovine papillomavirus. Virology, 172: 253-261, 1989.
17. Hermonat, P. L. Inhibition of bovine papillomavirus plasmid DNA replication by adeno-associated virus. Virology, 189: 329-333, 1992.
18. Hermonat, P. L. Adeno-associated virus inhibits human papillomavirus type 16: a viral interaction implicated in cervical cancer. Cancer Res., 54: 2278-2281, 1994
19. Horer, M., Weger, S., Butz, K., Hoppe-Seyler, F., Geisen, C., and Kleinschmidt, J. A. Mutational analysis of adeno-associated virus Rep protein-mediated inhibition of heterologous and homologous promoters J. Virol., 69: 5485-5496, 1995.
20. Beaton, A., Palumb, P., and Berns, K. I. Expression from the adeno-associated virus p5 and p19 promoters is negatively regulated in trans by the rep protein. J. Virol., 63: 4450-4454, 1989.
21. Rittner, K., Heilbronn, R., Kleinschmidt, J. A., and Sczakeil, G. Adeno-associated virus type 2-mediated inhibition of human immunodeficiency virus type 1 (HIV-1) replication, involvement of p78/p68rep and the HIV-1 long terminal repeat. J. Gen. Virol., 73, 2877-2981, 1992
22. Kotin, R. M., Siniscalco, M., Samulski, R. J., Zhu, X. D., Hunter, L., Laughlin, C. A., McLaughlin, S., Muzyczka, N., Rocchi, M., and Berns, K. I. Site-specific integration by adeno-associated virus. Proc. Natl. Acad. Sci. USA, 87: 2211-2215, 1990.
23. Samulski, R. J., Zhu, X., Xiao, X., Brook, J. D., Housman, D. E., Epstein, N., and Hunter, L. A. Targeted integration of adeno-associated virus (AAV) into human chromosome 19. EMBO J., 10: 3941-3950, 1992
24. Weitzman, M. D., Kyostio, S. R., Kotin, R. M., and Owens, R. A. Adeno-associated virus (AAV) Rep protein mediates complex formation between AAV DNA and its integration site in human DNA. Proc. Natl. Acad. Sci USA, 94: 5806-5812, 1994.
25. Angel, P., and Karin, M. The role of Jun, Fos, and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta, 1072: 129-157, 1991.
26. McBride, A. A., Romanczuk, H., and Howley, P. M. The papillomavirus E2 regulatory proteins. J Biol. Chem., 266: 1811-1814, 1991.
27. Van Beveren, C., Enami, S., Curran, T., and Verma, I. M. FBR murine osteosarcoma virus Virology, 135, 229-243, 1984.
28. Courey, A. J., Holtzman, D. A., Jackson, S. P., and Tjian, R. Synergistic activation by the glutamine-rich domains of human transcription factor Sp1 Cell, 59: 827-836, 1989
29. Hermonat, P. L., and Muzyczka, N. Use of adeno-associated virus as a mammalian DNA cloning vector: transduction of neomycin resistance into mammalian tissue culture cells. Proc Natl. Acad Sci. USA, 81: 6466-6470, 1984
30. Ishii, S., Merlino, G. T. and Pastan, I. Promoter region of the human harvey ras proto-oncogene: similarity to the EGF receptor proto-oncogene promoter. Science (Washington DC), 230: 1378-1381, 1985.
31. Towbin, H., Staehelin, T., and Gordon, J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl. Acad. Sci. USA, 76: 4350-4354, 1979
32. Batchu, R. B., and Hermonat, P. L. The trans-inhibitory Rep78 protein of adeno-associated virus binds to TAR region DNA of the human immunodeficiency virus type 1 long terminal repeat. FEBS Lett., 367: 267-271, 1995
33. Chen, C., and Okayama, H. High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol., 7: 2745-2752, 1987.
34. White, B. A., and Bancroft, F. C. Cytoplasmic dot hybridization: simple analysis of relative mRNA levels in multiple small cell or tissue samples. J. Biol Chem., 257: 8569-8572.
35. Hermonat, P. L., Spalholz, B. A., and Howley, P. M. The bovine papillomavirus P2443 promoter is E2 trans-responsive evidence for E2 autoregulation. EMBO J., 7: 2815-2822, 1988.
36. Labow, M. A., Graf, L. H., and Berns, K. I. Adeno-associated virus gene expression inhibits cellular transformation by heterologous genes. Mol. Cell Biol, 7: 1320-1325, 1987.
37. Van Beveren, C., Enami, S., Curran, T., and Verma, I. M. FBR murine osteosarcoma virus. II. Nucleotide sequence of the provirus reveals that the genome contains sequences acquired from two cellular genes Virology, 135: 229-243, 1984.
38. Krady, J. K., and Ward, D. C. Transcriptional activation by the parvoviral nonstructural protein NS-1 is mediated via a direct interaction with Sp1. Mol Cell. Biol., 15: 524-533, 1995.
39. Winocour, E., Callahan, M. F., and Huberman, E. Perturbation of the cell cycle by adeno-associated virus Virology, 167, 393-399, 1988.
40. Yang, Q., Fang, C., and Trempe, J. P. Characterization of cell lines which inducibly express the adeno-associated virus rep proteins. J Virol., 68: 4847-4856, 1994
41. Holscher, C. A., Horer, M., Kleinschmidt, J. A., Zentgraf, H., Burkle, A., and Heilbronn, R. Cell lines inducibly expressing the adeno-associated virus (AAV) rep gene, requirements for productive replication of rep negative AAV mutants. J. Virol., 68: 7169-7177, 1994.
42. Ishii, S., Young-Hua, X., Stratton, H., Roe, A., Merlino, G. T., and Patan, I. Characterization and sequence of the promoter region of the human epidermal growth factor receptor gene. Proc. Natl. Acad. Sci. USA, 82: 4920-4924, 1995.
43. McCarty, D. M., Pereira, D. J., Zolotukhin, I., Zhou, X., Ryan, J. H., and Muzyczka, N. Identification of linear DNA sequences that specifically bind the adeno-associated virus Rep protein. J. Virol., 68: 4988-4997, 1994.
44. Chiorini, J. A., Weiner, S. M., Owens, R. A., Kyostio, S. R., Kotin, R. M., and Safer, B. Sequence requirements for stable binding and function of Rep68 on the AAV-2 inverted terminal repeats. J. Virol., 68: 7448-7457, 1994.
45. McCarty, D. M., Ryan, J. H., Zolotukhin, S., Zhou, X., and Muzyczka, N. Interaction of the adeno-associated virus Rep protein with a sequence within the A palindrome of the viral terminal repeat. J. Virol., 68: 4998-5006, 1994.
46. Hoey, T., Weinzieri, R. O. J., Gill, G., Chen, J-L., Dynlacht, B. D., and Tjian, R. Molecular cloning and functional analysis of Drosophila TAF110 reveal properties expected of coactivators. Cell, 72: 247-260, 1993.