Dehydrocrotonin and its derivative, dimethylamide-crotonin induce apoptosis with lipid peroxidation and activation of caspases-2, -6 and -9 in human leukemic cells HL60

Toxicology

Volumn 203, Issue 1-3, 2004, Pages 123-137

  Anazetti, Maristella C ^a   Melo, Patricia S ^a   Durán, Nelson ^a,b   Haun, Marcela ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b UNIVERSIDADE DE MOGI DAS CRUZES   (Brazil)

Author keywords

Apoptosis; Caspase activity; Dehydrocrotonin; Dimethylamide crotonin; Glutathione; HL60 cells; Lipid peroxidation

Indexed keywords

CASPASE 2; CASPASE 6; CASPASE 9; CROTONIC ACID DERIVATIVE; CYCLOSPORIN A; CYTOCHROME C; DEHYDROCROTONIN; DITERPENE; GLUTATHIONE; LACTONE DERIVATIVE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL SWELLING; CONTROLLED STUDY; CROTON; CYTOTOXICITY; ENZYME ACTIVITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; LIPID PEROXIDATION; MEMBRANE PERMEABILITY; MITOCHONDRION; PRIORITY JOURNAL;

ANNEXIN A5; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 2; CASPASE 6; CASPASE 9; CASPASES; CELL SURVIVAL; DITERPENES; DITERPENES, CLERODANE; ENZYME ACTIVATION; FLUORESCEIN-5-ISOTHIOCYANATE; HL-60 CELLS; HUMANS; LACTONES; LIPID PEROXIDATION; MITOCHONDRIA; PERMEABILITY; PLANT BARK; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

CROTON;

EID: 4444261752     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2004.06.003     Document Type: Article

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