Neonatal exposure to diethylstilbestrol leads to impaired action of androgens in adult male hamsters

Reproductive Toxicology

Volumn 19, Issue 1, 2004, Pages 53-63

  Karri, SriTulasi ^a   Johnson, Heather ^a   Hendry III, William J ^b   Williams, Simon C ^c   Khan, Shafiq A ^a,c  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

^b WICHITA STATE UNIVERSITY   (United States)

^c CLARK ATLANTA UNIVERSITY   (United States)

Author keywords

Androgen action; Diethylstilbestrol; Seminal vesicle; Spermatogenesis; Steroid receptors; Testes

Indexed keywords

ANDROGEN; CALRETICULIN; DIETHYLSTILBESTROL; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; ORNITHINE DECARBOXYLASE; PROTEIN; PROTEIN SEC 23B; TESTOSTERONE PROPIONATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HAMSTER; HISTOPATHOLOGY; HORMONE ACTION; HORMONE RESPONSIVE ELEMENT; MALE; NEWBORN; NONHUMAN; NORTHERN BLOTTING; ORGAN WEIGHT; PERINATAL DEVELOPMENT; REPRODUCTIVE TOXICITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEMINAL VESICLE; SPERMATOGENESIS;

ANDROGEN ANTAGONISTS; ANDROGENS; ANIMALS; ANIMALS, NEWBORN; BLOTTING, NORTHERN; CRICETINAE; DIETHYLSTILBESTROL; DIHYDROTESTOSTERONE; DRUG THERAPY, COMBINATION; ESTROGENS, NON-STEROIDAL; GENE EXPRESSION; INJECTIONS, SUBCUTANEOUS; MALE; ORGAN SIZE; RECEPTORS, ANDROGEN; RECEPTORS, ESTROGEN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEMINAL VESICLES; SPERMATOGENESIS; TESTIS; TESTOSTERONE; TESTOSTERONE PROPIONATE;

ANIMALIA; CRICETINAE;

EID: 4444243012     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2004.06.011     Document Type: Article

References (53)

1. T. Colborn, F.S. vom Saal, and A.M. Soto Developmental effects of endocrine-disrupting chemicals in wildlife and humans Environ Health Perspect 101 1993 378 384
2. R.M. Giusti, K. Iwamoto, and E.E. Hatch Diethylstilbestrol revisited: a review of the long-term health effects Ann Intern Med. 122 1995 778 788
3. K.S. Korach Surprising places of estrogenic activity Endocrinology 132 1993 2277 2278
4. R.M. Sharpe, and N.E. Skakkebaek Are oestrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 341 1993 1392 1395
5. J.A. McLachlan, R.R. Newbold, M.E. Burow, and S.F. Li From malformations to molecular mechanisms in the male: three decades of research on endocrine disrupters Apmis 109 2001 263 272
6. R.M. Sharpe, J.S. Fisher, M.M. Millar, S. Jobling, and J.P. Sumpter Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production Environ Health Perspect 103 1995 1136 1143
7. H. Bern The fragile fetus C.C. Colborn Chemically induced alternations in sexual and functional development. 1992 Princton Scientific Publishing Co. Princton, NJ 9 15
8. B.C. Bullock, R.R. Newbold, and J.A. McLachlan Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure Environ Health Perspect 77 1988 29 31
9. J.A. McLachlan, R.R. Newbold, and B. Bullock Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol Science 190 1975 991 992
10. R.R. Newbold, B.C. Bullock, and J.A. McLachlan Testicular tumors in mice exposed in utero to diethylstilbestrol J Urol. 138 1987 1446 1450
11. G.S. Prins Neonatal estrogen exposure induces lobe-specific alterations in adult rat prostate androgen receptor expression Endocrinology 130 1992 3703 3714
12. S.A. Khan, R.B. Ball, and W.J. Hendry 3rd Effects of neonatal administration of diethylstilbestrol in male hamsters: disruption of reproductive function in adults after apparently normal pubertal development Biol Reprod. 58 1998 137 142
13. A.J. Wilcox, D.D. Baird, C.R. Weinberg, P.P. Hornsby, and A.L. Herbst Fertility in men exposed prenatally to diethylstilbestrol N Engl J Med. 332 1995 1411 1416
14. W.J. Hendry 3rd, X. Zheng, W.W. Leavitt, W.S. Branham, and D.M. Sheehan Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri Cancer Res. 57 1997 1903 1908
15. W.J. Hendry 3rd, and W.W. Leavitt Altered morphogenesis of the immature hamster uterus following neonatal exposure to diethylstilbestrol Differentiation 52 1993 221 227
16. X. Zheng, and W.J. Hendry 3rd Neonatal diethylstilbestrol treatment alters the estrogen-regulated expression of both cell proliferation and apoptosis-related proto-oncogenes (c-jun, c-fos, c-myc, bax, bcl-2, and bcl-x) in the hamster uterus Cell Growth Differ. 8 1997 425 434
17. P. Niklowitz, S. Khan, M. Bergmann, K. Hoffmann, and E. Nieschlag Differential effects of follicle-stimulating hormone and luteinizing hormone on Leydig cell function and restoration of spermatogenesis in hypophysectomized and photoinhibited Djungarian hamsters (Phodopus sungorus) Biol Reprod. 41 1989 871 880
18. R.M. Sharpe, S. Maddocks, M. Millar, J.B. Kerr, P.T. Saunders, and C. McKinnell Testosterone and spermatogenesis. Identification of stage-specific, androgen-regulated proteins secreted by adult rat seminiferous tubules J Androl. 13 1992 172 184
19. C.A. Awoniyi, B.R. Zirkin, V. Chandrashekar, and W.D. Schlaff Exogenously administered testosterone maintains spermatogenesis quantitatively in adult rats actively immunized against gonadotropin-releasing hormone Endocrinology 130 1992 3283 3288
20. G. Majdic, R.M. Sharpe, P.J. O'Shaughnessy, and P.T. Saunders Expression of cytochrome P450 17alpha-hydroxylase/C17-20 lyase in the fetal rat testis is reduced by maternal exposure to exogenous estrogens Endocrinology 137 1996 1063 1070
21. N. Atanassova, C. McKinnell, M. Walker, K.J. Turner, J.S. Fisher, and M. Morley Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood Endocrinology 140 1999 5364 5373
22. C. McKinnell, N. Atanassova, K. Williams, J.S. Fisher, M. Walker, and K.J. Turner Suppression of androgen action and the induction of gross abnormalities of the reproductive tract in male rats treated neonatally with diethylstilbestrol J Androl. 22 2001 323 338
23. B.A. Keel, and T.O. Abney Oestrogenic regulation of testicular androgen production during development in the rat J Endocrinol. 105 1985 211 218
24. W.J. Hendry 3rd, B.L. DeBrot, X. Zheng, W.S. Branham, and D.M. Sheehan Differential activity of diethylstilbestrol versus estradiol as neonatal endocrine disruptors in the female hamster (Mesocricetus auratus) reproductive tract Biol Reprod. 61 1999 91 100
25. L. Seethalakshmi, C. Flores, A.A. Carboni, and M. Menon Quantitative maintenance of spermatogenesis in cyclosporine-treated rats by exogenous administration of testosterone propionate J Androl. 11 1990 491 497
26. A.K. Chowdhury, and R.K. Tcholakian Effects of various doses of testosterone propionate on intratesticular and plasma testosterone levels and maintenance of spermatogenesis in adult hypophysectomized rats Steroids 34 1979 151 162
27. A.A. Ismail, G.D. Niswender, and A.R. Midgley Jr. Radioimmunoassay of testosterone without chromatography J Clin Endocrinol Metab. 34 1972 177 184
28. N. Zhu, and Z. Wang Calreticulin expression is associated with androgen regulation of the sensitivity to calcium ionophore-induced apoptosis in LNCaP prostate cancer cells Cancer Res. 59 1999 1896 1902
29. J.P. Paccaud, W. Reith, J.L. Carpentier, M. Ravazzola, M. Amherdt, and R. Schekman Cloning and functional characterization of mammalian homologues of the COPII component Sec23 Mol Biol Cell. 7 1996 1535 1546
30. F. Klamt, F. Dal-Pizzol, N.C. Ribeiro, E.A. Bernard, M.S. Benfato, and J.C. Moreira Retinol-induced elevation of ornithine decarboxylase activity in cultured rat Sertoli cells is attenuated by free radical scavenger and by iron chelator Mol Cell Biochem. 208 2000 71 76
31. Q. Zhang, R. Haleem, X. Cai, and Z. Wang Identification and characterization of a novel testosterone-regulated prominin-like gene in the rat ventral prostate Endocrinology 143 2002 4788 4796
32. C. Chang, J. Kokontis, S. Swift, and S.T. Liao Molecular cloning and structural analysis of complementary DNA of human and rat androgen receptors Prog Clin Biol Res. 322 1990 53 63
33. C.S. Chang, J. Kokontis, and S.T. Liao Molecular cloning of human and rat complementary DNA encoding androgen receptors Science 240 1988 324 326
34. R.A. Hess, D.H. Gist, D. Bunick, D.B. Lubahn, A. Farrell, and J. Bahr Estrogen receptor (alpha and beta) expression in the excurrent ducts of the adult male rat reproductive tract J Androl. 18 1997 602 611
35. H. Cardenas, K.A. Burke, R.M. Bigsby, W.F. Pope, and K.P. Nephew Estrogen receptor beta in the sheep ovary during the estrous cycle and early pregnancy Biol Reprod. 65 2001 128 134
36. O.M. Tirado, E.D. Martinez, O.C. Rodriguez, M. Danielsen, D.M. Selva, and J. Reventos Methoxyacetic acid disregulation of androgen receptor and androgen-binding protein expression in adult rat testis Biol Reprod. 68 2003 1437 1446
37. P.R. Manna, P. Roy, B.J. Clark, D.M. Stocco, and I.T. Huhtaniemi Interaction of thyroid hormone and steroidogenic acute regulatory (StAR) protein in the regulation of murine Leydig cell steroidogenesis J Steroid Biochem Mol Biol. 76 2001 167 177
38. L. O'Donnell, K. Pratis, P.G. Stanton, D.M. Robertson, and R.I. McLachlan Testosterone-dependent restoration of spermatogenesis in adult rats is impaired by a 5alpha-reductase inhibitor J Androl. 20 1999 109 117
39. N. Ahmad, G.C. Haltmeyer, and K.B. Eik-Nes Maintenance of spermatogenesis in rats with intratesticular implants containing testosterone or dihydrotestosterone (DHT) Biol Reprod. 8 1973 411 419
40. G.S. Prins, L. Birch, J.F. Couse, I. Choi, B. Katzenellenbogen, and K.S. Korach Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice Cancer Res. 61 2001 6089 6097
41. R.A. Hess, D. Bunick, D.B. Lubahn, Q. Zhou, and J. Bouma Morphologic changes in efferent ductules and epididymis in estrogen receptor-alpha knockout mice J Androl. 21 2000 107 121
42. S.S. Dadras, X. Cai, I. Abasolo, and Z. Wang Inhibition of 5alpha-reductase in rat prostate reveals differential regulation of androgen-response gene expression by testosterone and dihydrotestosterone Gene Expr. 9 2001 183 194
43. C.A. Heinlein, and C. Chang Androgen receptor (AR) coregulators: an overview Endocr Rev. 23 2002 175 200
44. O.A. Janne, A.M. Moilanen, H. Poukka, N. Rouleau, U. Karvonen, and N. Kotaja Androgen-receptor-interacting nuclear proteins Biochem Soc Trans. 28 2000 401 405
45. N. Kotaja, M. Vihinen, J.J. Palvimo, and O.A. Janne Androgen receptor-interacting protein 3 and other PIAS proteins cooperate with glucocorticoid receptor-interacting protein 1 in steroid receptor-dependent signaling J Biol Chem. 2002
46. E. Holter, N. Kotaja, S. Makela, L. Strauss, S. Kietz, and O.A. Janne Inhibition of androgen receptor (AR) function by the reproductive orphan nuclear receptor Dax-1 Mol Endocrinol. 16 2002 515 528
47. G. Buchanan, M. Yang, J.M. Harris, H.S. Nahm, G. Han, and N. Moore Mutations at the boundary of the hinge and ligand binding domain of the androgen receptor confer increased transactivation function Mol Endocrinol. 15 2001 46 56
48. I. Knoke, A. Allera, and P. Wieacker Significance of the CAG repeat length in the androgen receptor gene (AR) for the transactivation function of an M780I mutant AR Hum Genet. 104 1999 257 261
49. P. Doesburg, C.W. Kuil, C.A. Berrevoets, K. Steketee, P.W. Faber, and E. Mulder Functional in vivo interaction between the amino-terminal, transactivation domain and the ligand binding domain of the androgen receptor Biochemistry 36 1997 1052 1064
50. G.S. Prins, C. Woodham, M. Lepinske, and L. Birch Effects of neonatal estrogen exposure on prostatic secretory genes and their correlation with androgen receptor expression in the separate prostate lobes of the adult rat Endocrinology 132 1993 2387 2398
51. R.M. Sharpe, N. Atanassova, C. McKinnell, P. Parte, K.J. Turner, and J.S. Fisher Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development Biol Reprod. 59 1998 1084 1094
52. N. Atanassova, C. McKinnell, K. Williams, K.J. Turner, J.S. Fisher, and P.T. Saunders Age-, cell- and region-specific immunoexpression of estrogen receptor alpha (but not estrogen receptor beta) during postnatal development of the epididymis and vas deferens of the rat and disruption of this pattern by neonatal treatment with diethylstilbestrol Endocrinology 142 2001 874 886
53. N. Atanassova, C. McKinnell, K.J. Turner, M. Walker, J.S. Fisher, and M. Morley Comparative effects of neonatal exposure of male rats to potent and weak (environmental) estrogens on spermatogenesis at puberty and the relationship to adult testis size and fertility: evidence for stimulatory effects of low estrogen levels Endocrinology 141 2000 3898 3907