Effects of neonatal administration of diethylstilbestrol in male hamsters: Disruption of reproductive function in adults after apparently normal pubertal development

Biology of Reproduction

Volumn 58, Issue 1, 1998, Pages 137-142

  Khan, Shafiq A ^a,b   Ball, Rebecca B ^a   Hendry III, William J ^c  

^a TEXAS TECH UNIVERSITY   (United States)

^b TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c WICHITA STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DIETHYLSTILBESTROL; ESTRADIOL; TESTOSTERONE;

ACCESSORY SEX ORGAN; ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYPTORCHISM; EPIDIDYMIS DISEASE; HAMSTER; INVOLUTION; MALE; MALE GENITAL SYSTEM; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PUBERTY; SPERMATOGENESIS; TERATOGENICITY; TESTIS TUMOR; TESTOSTERONE BLOOD LEVEL;

ANIMALS; ANIMALS, NEWBORN; CRICETINAE; CRYPTORCHIDISM; DIETHYLSTILBESTROL; EPIDIDYMIS; ESTRADIOL; FEMALE; GENITALIA, MALE; MALE; MESOCRICETUS; ORGAN SIZE; PREGNANCY; REPRODUCTION; SEXUAL MATURATION; SPERMATOGENESIS; TESTICULAR DISEASES; TESTIS; TESTOSTERONE;

ANIMALIA; CRICETINAE; MESOCRICETUS AURATUS;

EID: 0031973544     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod58.1.137     Document Type: Article

References (42)

1. Iguchi T. Cellular effects of early exposure to sex hormones and anti-hormones. Int Rev Cytol 1992; 139:1-5.
2. White R, Jobling S, Hoare SA, Sumpter JP, Parker MG. Environmentally persistent alkylphenolic compounds are estrogenic. Endocrinology 1994; 135:175-182.
3. McLachlan JA, Newbold RR. Estrogens and development. Environ Health Persect 1987; 75:25-27.
4. Krishnan AV, Stathis P, Permuth SP, Tokes L, Feldman D. Bisphenol-A: an estrogenic substance is released from polycarbonate flasks during autoclaving. Endocrinology 1993; 132:2279-2286.
5. Soto AM, Justicia H, Wnay JW, Sonnenschein C. p-Nonyl-phenol: an estrogenic xenobiotic released from "modified" polystyrene. Environ Health Perspect 1991; 92:167-173.
6. Korach KS. Editorial: surprising places of estrogenic activity. Endocrinology 1993; 132:2277-2278.
7. Colborn T, von Saal RS, Soto AM. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ Health Perspect 1993; 101:378-384.
8. Raloff J. Gender benders: are environmental "hormones" emasculating wildlife? Science News 1994; 145:24-27.
9. London WP. Male sexual development in "a sea of estrogen". Lancet 1993; 342:124.
10. Sharpe RM. Declining sperm count in men - is there an endocrine cause. J Endocrinol 1993; 136:357-360.
11. Sharpe RM, Skakkebaek NE. Are estrogens involved in falling sperm counts and disorders of the male reproductive tract? Lancet 1993; 341: 1392-1395.
12. Herbst AL, Ulfeder H, Poskanzer DC. Adenocarcinoma of the vagina: association of maternal stilbestrol therapy with tumor appearance in young women. New Engl J Med 1971; 284:878-881.
13. Herbst AL, Scully RE, Robboy SJ. Prenatal diethylstilbestrol exposure and human genital tract abnormalities. Natl Cancer Inst Monogr 1979; 51:25-35.
14. Hornsby PP, Wilcox AJ, Weinberg CR, Herbst A. Effects on the menstrual cycle of in utero exposure to diethylstilbestrol. Am J Obstet Gynecol 1994; 170:709-715.
15. Wilcox AJ, Baird DD, Weinberg CR, Hornsby PP, Herbst AL. Fertility in men exposed prenatally to diethylstilbestrol. New Engl J Med 1995; 332:1411-1416.
16. Giusti RM, Iwamoto K, Hatch EE. Diethylstilbestrol revisited: A review of the long-term health effects. Ann Intern Med 1995; 122:778-788.
17. McLachlan JA, Newbold RR, Bullock B. Reproductive tract lesions in male mice prenatally exposed to diethylstilbestrol. Science 1975; 190:991-992.
18. Newbold RR, Bullock BC, McLachlan JA. Testicular tumors in mice exposed prenatally to diethylstilbestrol. J Urol 1987; 138:1446-1450.
19. Bullock BC, Newbold RR, McLachlan JA. Lesions of testis and epididymis associated with prenatal diethylstilbestrol exposure. Environ Health Perspect 1988; 77:29-31.
20. Arnold SF, Klotz DM, Collins BM, Vonier PM, Guillette LJ Jr, McLachlan JA. Synergistic activation of estrogen receptor with combinations of environmental chemicals. Science 1996; 272:1489-1492.
21. Ramamoorthy K, Wang F, Chen I-C, Morris JD, McDonnell DP, Leonard LS, Gaido KW, Bocchinfuso WP, Korach KS, Safe S. Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus. MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. Endocrinology 1997; 138:1520-1527.
22. Kaiser J. Endocrine disrupters: synergy paper questioned at toxicology meeting. Science 1997; 277:1879.
23. Leavitt WW, Evans RW, Hendry WJ. Etiology of DES-induced uterine tumors in the Syrian hamster. In: Leavitt WW (ed.), Hormones and Cancer. New York: Plenum Publishing Corporation; 1982: 63-86.
24. Hendry WJ, Branham WS, Sheehan DM. The hamster cheek pouch as a convenient ectopic site for studies of uterine morphogenesis and endocrine responsiveness. Differentiation 1992; 51:49-54.
25. Hendry III WJ, Zheng X, Leavitt WW, Branham WS, Sheehan DM. Endometrial hyperplasia and apoptosis following neonatal diethylstilbestrol exposure and subsequent estrogen stimulation in both host and transplanted hamster uteri. Cancer Res 1997; 57:1903-1908.
26. Zheng X, Hendry III WJ. Neonatal diethylstilbestrol treatment alters the estrogen regulated expression of both cell proliferation and apoptosis-related protooncogenes (c-jun, c-fos, c-myc, bax, bcl-2 and bcl-x) in the hamster uteri. Cell Growth Differ 1997; 8:425-434.
27. Hendry WJ, Leavitt WW. Altered morphogenesis of the immature hamster uterus following neonatal exposure to diethylstilbestrol. Differentiation 1993; 52:221-227.
28. Niklowitz P, Khan S, Bergmann M, Hoffmann K, Nieschlag E. Differential effects of follicle-stimulating hormone and luteinizing hormone on Leydig cell function and restoration of spermatogenesis in hypophysectomized and photoinhibited Djungarian hamsters (Phodopus sungorus). Biol Reprod 1989; 41:871-880.
29. Vornberger W, Prins G, Musto NA, Suarez-Quian CA. Androgen receptor distribution in rat testis: new implications for androgen regulation of spermatogenesis. Endocrinology 1994; 134:2307-2316.
30. Savu L, Nunez EA, Jayle MF. High affinity testosterone, corticosterone and progesterone binding activities in pregnant hamster serum. Endocrinology 1977; 101:369-377.
31. Schatz R, Laugier C, Soto AM, Sonnenschein C. Alpha-fetoprotein serum levels and the development of estrogen-sensitive cell multiplication in the hamster uterus. Biol Reprod 1983; 28:1148-1154.
32. Marselos M, Tomatis L. Diethylstilbestrol: I. Pharmacology, toxicology and carcinogenicity in humans. Eur J Cancer 1992; 28A:1182-1189.
33. Metzler M. Metabolic activation of xenobiotic stilbene estrogens. Fed Proc 1987; 46:1855-1857.
34. Korach KS, Metzler M, McLachlan JA. Estrogenic activity in vivo and in vitro of some diethylstilbestrol metabolites and analogs. Proc Natl Acad Sci USA 1978; 75:468-471.
35. Gaytan F, Pirilla L, Aguilar R, Lucena MC, Paniagua R. Effects of neonatal estrogen administration on rat testis development with particular reference to Sertoli cells. J Androl 1986; 7:112-121.
36. Smith DA, Walker BE. Evidence of hypothalamic involvement in the mechanism of transplacental carcinogenesis by diethylstilbestrol. Cancer Lett 1992; 67:55-59.
37. Gorski RA, Harlan RE, Christensen LW. Perinatal hormone exposure and the development of neuroendocrine regulatory processes. J Toxicol Environ Health 1977; 3:97-121.
38. Russell LD, Sinha Hikim AP, Ghosh S, Bartke A. Structure-function relationships in somatic cells of the testis and accessory reproductive glands. In: Bartke A (ed.), Function of Somatic Cells in the Testis. New York: Springer-Verlag; 1994: 55-84.
39. Bartke A. Male hamster reproductive endocrinology. In: Siegel HI (ed.), The Hamster. New York: Plenum Press: 1985: 73-98.
40. Ghersevich S, Nokelainen P, Poutanen M, Orava M, Autio-Harmainen H, Rajaniemi H, Vihko R. Rat 17β-hydroxysteroid dehydrogenase type 1: primary structure of enzyme expression in rat ovary by diethylstilbestrol and gonadotropins in vivo. Endocrinology 1994; 135: 1477-1487.
41. Zanger RC, Buhler DR, Springer DL. Neonatal exposure to xenobiotics alters adult hepatic protein kinase C alpha levels and testosterone metabolism: differential effects by diethylstilbestrol and phenobarbital. J Toxicol Environ Health 1995; 45:47-58.
42. Zheng X, Branham WS, Sheehan DM, Hendry III WJ. Neonatal exposure to diethylstilbestrol leads to persistent induction of c-jun, c-fos, and c-myc proteins plus apoptosis in hamster endometrium epithelium. In: Proceedings of the 77th annual meeting of the Endocrine Society; Washington, DC; 1995; Abstract 667.