Morphologic changes in efferent ductules and epididymis in estrogen receptor-α knockout mice

Journal of Andrology

Volumn 21, Issue 1, 2000, Pages 107-121

  Hess, Rex A ^a   Bunick, David ^a   Lubahn, Dennis B ^b   Zhou, Qing ^a   Bouma, Jerry ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

Histopathology; Testis

Indexed keywords

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS; HISTOPATHOLOGY; HORMONE ACTION; KNOCKOUT MOUSE; MALE; MALE GENITAL SYSTEM; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETE TESTIS;

ANIMALS; EPIDIDYMIS; EPITHELIUM; ESTROGEN RECEPTOR ALPHA; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, KNOCKOUT; MICROSCOPY, ELECTRON; RECEPTORS, ESTROGEN; REFERENCE VALUES; RETE TESTIS;

EID: 0033965035     PISSN: 01963635     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (68)

1. Abe K, Takano H, Ito T. Ultrastructure of the mouse epididymal duct with special reference to the regional differences of the principal cells. Arch Histol Jpn. 1983;46:51-68.
2. Abou-Haila A, Fain-Maurel M-A. Regional differences of the proximal part of mouse epididymis: morphological and histochemical characterization. Anat Rec. 1984;209:197-208.
3. Adamali HI, Hermo L. Apical and narrow cells are distinct cell types differing in their structure, distribution, and functions in the adult rat epididymis. J Androl. 1996;17:208-222.
4. Antakly T, Pelletier G, Zeytinoglu F, Labrie F. Changes of cell morphology and prolactin secretion induced by 2-Br-alpha-ergocryptine, estradiol, and thyrotropin-releasing hormone in rat anterior pituitary cells in culture. J Cell Biol. 1980;86:377-387.
5. Ashdown RR, Ford CM. Bilateral epididymal spermiostasis in a ram. Vet Rec. 1967;80:492-494.
6. Au CL, Wong PY. Luminal acidification by the perfused rat cauda epididymidis. J Physiol (Lond). 1980;309:419-427.
7. Benten WP, Lieberherr M, Giese G, Wunderlich F. Estradiol binding to cell surface raises cytosolic free calcium in T cells. FEBS Lett. 1998; 422:349-353.
8. Blom E, Christensen NO. The etiology of spermiostasis in the bull. Nord Vet Med. 1960;12:453-470.
9. Chen H, Suzuki S. Effects of estradiol on carbonic anhydrase and Mg(2+)-HCO3(-)-ATPase activities in rat duodenal microvilli and kidney tubules. Chung Kuo Yao Li Hsueh Pan. 1991;12:219-222.
10. Clulow J, Jones RC, Hansen LA. Micropuncture and cannulation studies of fluid composition and transport in the ductuli efferentes testis of the rat: comparisons with the homologous metanephric proximal tubule. Exp Physiol. 1994;79:915-928.
11. Cohen JP, Hoffer AP, Rosen S. Carbonic anhydrase localization in the epididymis and testis of the rat: histochemical and biochemical analysis. Biol Reprod. 1976;14:339-346.
12. Comer MT, Leese HJ, Southgate J. Induction of a differentiated ciliated cell phenotype in primary cultures of Fallopian tube epithelium. Hum Reprod. 1998;13:3114-3120.
13. Cooper ER, Jackson H. The vasa efferentia in the rat and mouse. J Reprod Fertil. 1972;28:317-319.
14. Couse JF, Lindzey J, Grandien K, Gustafsson J-A, Korach KS. Tissue distribution and quantitative analysis of estrogen receptor-a (ERa) and estrogen receptor-b (ERb) messenger ribonucleic acid in the wild-type and ERa-knockout mouse. Endocrinology. 1997;138:4613-4621.
15. Coutts AS, Davie JR, Dotzlaw H, Murphy LC. Estrogen regulation of nuclear matrix-intermediate filament proteins in human breast cancer cells. J Cell Biochem. 1996;63:174-184.
16. Dick IM, Prince RL. Estrogen effects on the renal handling of calcium in the ovariectomized perfused rat. Kidney Int. 1997;51:1719-1728.
17. Drews U, Schleicher G, Stumpf WE, Thiedemann KU. Androgen receptor-deficient Tfm cells in the mosaic epididymis of sex-reversed mice heterozygous for Tfm: an autoradiographic study with [3H]-dihydrotestosterone and [3H]-estradiol. Anat Rec. 1988;220:393-396.
18. Eddy EM, Washburn TF, Bunch DO, Goulding EH, Gladen BC, Lubahn DB, Korach KS. Targeted disruption of the estrogen receptor gene in male mice causes alteration of spermatogenesis and infertility. Endocrinology. 1996;137:4796-4805.
19. Ediger TR, Kraus WL, Weinman EJ, Katzenellenbogen BS. Estrogen receptor regulation of the Na+/H+ exchanger regulatory factor: potential involvement in early estrogen effects on cell signaling and cytoarchitecture. Endocrinology. 1999;140:2976-2982.
20. Ergun S, Ungefroren H, Holstein AF, Davidoff MS. Estrogen and progesterone receptors and estrogen receptor-related antigen (ER-D5) in human epididymis. Mol Reprod Dev. 1997;47:448-455.
21. Fawcett DW, Dym M. A glycogen-rich segment of the tubuli recti and proximal portion of the rete testis in the guinea-pig. J Reprod Fertil. 1974;38:401-409.
22. Fisher JS, Millar MR, Majdic G, Saunders PT, Fraser HM, Sharpe RM. Immunolocalisation of estrogen receptor-alpha within the testis and excurrent ducts of the rat and marmoset monkey from perinatal life to adulthood. J Endocrinol. 1997;153:485-495.
23. Foley GL, Bassily N, Hess RA. Intratubular spermatic granulomas of the canine efferent ductules. Toxicol Pathol. 1995;23:731-734.
24. Goyal HO. Appendix epididymidis and aberrant ductules of the bull: light-microscopic and ultrastructural study. Acta Anat (Basel). 1983; 117:321-330.
25. Goyal HO, Bartol FF, Wiley AA, Khalil MK, Chiu J, Vig MM. Immunolocalization of androgen receptor and estrogen receptor in the developing testis and excurrent ducts of goats. Anat Rec. 1997;249:54-62.
26. Guttroff RF, Cooke PS, Hess RA. Blind-ending tubules and branching patterns of the rat ductuli efferentes. Anat Rec. 1992;232:423-431.
27. Harrison RG. The effect of ligation of the vasa efferentia on the rat testis. Proc Soc Study Fertil. 1953;7:97-100.
28. Hemeida NA, McEntee K. Spermiostasis of the ductuli efferentes of the bovine epididymis. Assiut Vet Med J. 1984;13:317-324.
29. Hermo L, Barin K, Robaire B. Structural differentiation of the epithelial cells of the testicular excurrent duct system of rats during postnatal development. Anat Rec. 1992;233:205-228.
30. Hermo L, Morales C. Endocytosis in nonciliated epithelial cells of the ductuli efferentes in the rat. Am J Anat. 1984;171:59-74.
31. Hess RA. Effects of environmental toxicants on the efferent ducts, epididymis and fertility. J Reprod Fertil Suppl. 1998;53:247-259.
32. Hess RA, Bunick D, Lee KH, Bahr J, Taylor JA, Korach KS, Lubahn DB. A role for oestrogens in the male reproductive system. Nature. 1997a;390:509-512.
33. Hess RA, Gist DH, Bunick D, Lubahn DB, Farrell A, Bahr J, Cooke PS, Greene GL. Estrogen receptor (a & b) expression in the excurrent ducts of the adult male rat reproductive tract, J Androl. 1997b;18: 602-611.
34. Hess RA, Moore BJ. Histological methods for the evaluation of the testis. In: Chapin RE, Heindel JJ. eds. Methods in Reproductive Toxicology. San Diego, California: Academic Press; 1993:52-85.
35. Hess RA, Moore BJ, Forrer J, Linder RE, Abuel-Atta AA. The fungicide benomyl (methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate) causes testicular dysfunction by inducing the sloughing of germ cells and occlusion of efferent ductules. Fundam Appl Toxicol. 1991;17: 733-745.
36. Hugo C, Nangaku M, Shankland SJ, Pichler R, Gordon K, Amieva MR, Couser WG, Furthmayr H, Johnson RJ. The plasma membrane-actin linking protein, ezrin, is a glomerular epithelial cell marker in glomerulogenesis, in the adult kidney and in glomerular injury. Kidney Int. 1998;54:1934-1944.
37. Iguchi T, Uesugi Y, Sato T, Ohta Y, Takasugi N. Developmental pattern of estrogen receptor expression in male mouse genital organs. Mol Androl. 1991;6:109-119.
38. Ilio KY, Hess RA. Structure and function of the ductuli efferentes: a review. Microsc Res Tech. 1994;29:432-467.
39. Kimura M, Wakasugi E, Uematsu K, Miyazato H, Furuta T, Teramura K, Otsuka K, Maekura S, Satou T, Hashimoto S. Pagetoid spread of intratubular germ cell neoplasia into rete testis forming tumor-like mass. Rinsho Byori. 1998;46:186-189.
40. Kuiper GG, Carlsson B, Grandien K, Enmark E, Hagghlad J, Nilsson S, Gustafsson JA. Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptors alpha and beta. Endocrinology. 1997;138:863-870.
41. Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustafsson JA. Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA. 1996;93:5925-5930.
42. Kuwahara M. The effects of ligation of vas deferens, corpus epididymidis and vasa efferentia on the testicular function in rats. Tohoku J Exp Med. 1976;120:251-257.
43. Lange J, Schlieps K, Lange K, Knoll-Kohler E. Activation of calcium signaling in isolated rat hepatocytes is accompanied by shape changes of microvilli. Exp Cell Res. 1997;234:486-497.
44. Liel Y, Shany S, Smirnoff P, Schwartz B. Estrogen increases 1,25-dihydroxyvitamin D receptors expression and bioresponse in the rat duodenal mucosa. Endocrinology. 1999;140:280-285.
45. Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proc Natl Acad Sci USA. 1993;90:11162-11166.
46. Marshall FF, Reiner WG, Goldberg BS. The embryologic origin of the caput epididymidis in the rat. Investig Urol (Berl). 1979;17:78-82.
47. Martino CD, Zamboni L. A morphologic study of the mesonephros of the human embryo. J Ultrastruct Res. 1966;16:399-427.
48. McLachlan JA, Newbold RR, Bullock B. Reproductive tract lesions in male mice exposed prenatally to diethylstilbestrol. Science. 1975;190: 991-992.
49. Morales C, Hermo L. Demonstration of fluid-phase endocytosis in epithelial cells of the male reproductive system by means of horseradish peroxidase-colloidal gold complex. Cell Tissue Res. 1983;230:503-510.
50. Murthy A, Gonzalez-Agosti C, Cordero E, Pinney D, Candia C, Solomon F. Gusella J, Ramesh V. NHE-RF. a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins. J Biol Chem. 1998;273:1273-1276.
51. Nakai M, Hess RA, Moore BJ, Guttroff RF, Strader LF, Linder RE. Acute and long-term effects of a single dose of the fungicide carbendazim (methyl 2-benzimidazole carbamate) on the male reproductive system in the rat. J Androl. 1992;13:507-518.
52. O'Loughlin PD, Morris HA. Oestrogen deficiency impairs intestinal calcium absorption in the rat. J Physiol (Lond). 1998;511:313-322.
53. Odor DL, Gaddum-Rosse P, Rumery RE, Blandau RJ. Cyclic variations in the oviuductal ciliated cells during the menstrual cycle and after estrogen treatment in the pig-tailed monkey, Macaca nemestrina. Anat Rec. 1980;198:35-57.
54. Palacios J, Regadera J, Paniagua R, Gamallo C, Nistal M. Immunohistochemistry of the human ductus epididymis. Anat Rec. 1993;235: 560-566.
55. Pelliniemi LJ, Kellokumpu-Lehtinen P, Hoffer AP. Glycogen accumulations in differentiating mesonephric ducts and tuhuli in male human embryos. Anat Embryol. 1983;168:445-453.
56. Podlasek CA, Seo RM, Clemens JQ, Ma L, Maas RL, Bushman W. Hoxa10 deficient male mice exhibit abnormal development of the accessory sex organs. Dev Dyn. 1999;214:1-12.
57. Russell LD, Burguet S. Ultrastructure of Leydig cells as revealed by secondary tissue treatment with a ferrocyanide-osmium mixture. Tissue Cell. 1977;9:751-766.
58. Sakai M, Imai T, Ohtake H, Azuma H, Otagiri M. Effects of absorption enhancers on cytoskeletal actin filaments in Caco-2 cell monolayers. Life Sci. 1998;63:45-54.
59. Saunders PTK, Maguire SM, Gaughan J, Millar MR. Expression of oestrogen receptor beta (ER-beta) in multiple rat tissues visualised by immunohistochemistry. J Endocrinol. 1997;154:13-16.
60. Schleicher G, Drews U, Stumpf WE, Sar M. Differential distribution of dihydrotestosterone and estradiol binding sites in the epididymis of the mouse. An autoradiographic study. Histochemistry. 1984;81:139-147.
61. Stephenson TJ. Quantitation of the nucleus. In: Underwood JCE. ed. Pathology of the Nucleus. Berlin, Germany: Springer Verlag; 1990:152-213.
62. Tezon JG, Blaquier JA. The organ culture of human epididymal tubules and their response to androgens. Mol Cell Endocrinol. 1981;21:233-242.
63. Tiedemann K. Fine structure of the epithelia of the Wolffian duct and of the vas deferens in fetal sheep. Z Zellforsch Mikrosk Anat. 1971;113: 230-248.
64. Torrey TW. The development of the urinogenital system of the albino rat. Am J Anat. 1943;72:113-147.
65. Verhage HG, Bareither ML, Jaffe RC, Akbar M. Cyclic changes in ciliation, secretion and cell height of the oviductal epithelium in women. Am J Anat. 1979;156:505-521.
66. Vic P, Vignon F, Derocq D, Rochefort H. Effect of estradiol on the ultrastructure of the MCF7 human breast cancer cells in culture. Cancer Res. 1982;42:667-673.
67. Winkler F, Wille KH. Early fetal development of the small intestine mucosa in cattle (Bos primigenius taurus). Anat Histol Embryol. 1998; 27:335-343.
68. Wong LB, Miller IF, Yeates DB. Nature of the mammalian ciliary metachronal wave. J Appl Physiol. 1993;75:458-467.