Melanocortin peptides stimulate prolactin gene expression and prolactin accumulation in rat pituitary aggregate cell cultures

Journal of Neuroendocrinology

Volumn 16, Issue 8, 2004, Pages 695-703

  Langouche, L ^a   Hersmus, N ^a   Papageorgiou, A ^a   Vankelecom, H ^a   Denef, Carl ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Agouti related protein; GH3 cell line; Melanocortins; Pituitary; Prolactin gene expression

Indexed keywords

AGOUTI RELATED PROTEIN; ALANINE 8 GAMMA2 INTERMEDIN; ALPHA INTERMEDIN; ESTRADIOL; GAMMA INTERMEDIN; GAMMA2 INTERMEDIN; GAMMA3 INTERMEDIN; GLUCOCORTICOID; GREEN FLUORESCENT PROTEIN; GROWTH HORMONE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MELANOCORTIN; MELANOCORTIN 3 RECEPTOR; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 5 RECEPTOR; MESSENGER RNA; PROLACTIN; THYROID HORMONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CELL AGGREGATION; CELL CULTURE; CELL STRAIN GH3; CONTROLLED STUDY; CULTURE MEDIUM; FEMALE; FLUORESCENCE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HYPOPHYSIS CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROLACTIN RELEASE; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ALPHA-MSH; ANIMALS; CELLS, CULTURED; FEMALE; GAMMA-MSH; GROWTH HORMONE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; PITUITARY GLAND; PROLACTIN; PROTEINS; RATS; RATS, WISTAR; RECEPTOR, MELANOCORTIN, TYPE 3; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 4444234949     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2004.01224.x     Document Type: Article

References (45)

1. Seger MA, Bennett HP. Structure and bioactivity of the amino-terminal frament of pro-opiomelanocortin. J Steroid Biochem 1986; 25: 703-710.
2. Chhajlani V, Wikberg JE. Molecular cloning and expression of the human melanocyte stimulating hormone receptor cDNA. FEBS Lett 1992; 309: 417-420.
3. Mountjoy KG, Robbins LS, Mortrud MT, Cone RD. The cloning of a family of genes that encode the melanocortin receptors. Science 1992; 257: 1248-1251.
4. Roselli-Rehfuss L, Mountjoy KG, Robbins LS, Mortrud MT, Low MJ, Tatro JB, Entwistle ML, Simerly RB, Cone RD. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc Natl Acad Sci USA 1993; 90: 8856-8860.
5. Chhajlani V, Muceniece R, Wikberg JE. Molecular cloning of a novel human melanocortin receptor. Biochem Biophys Res Commun 1993; 195: 866-873.
6. Gantz I, Konda Y, Tahsiro T, Shimoto Y, Miwa H, Munzert G, De Watson SJI, Valle J, Yamada T. Molecular cloning of a novel melanocortin receptor. J Biol Chem 1993; 268: 8246-8250.
7. Gantz I, Miwa H, Konda Y, Shimoto Y, Tashiro T, De Watson SJI, Valle J, Yamada T. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J Biol Chem 1993; 268: 15174-15179.
8. Lowry PJ, Silas L, McLean C, Linton EA, Estivaris FE. Pro-gamma-melanocyte-stimulating hormone cleavage in adrenal gland undergoing compensatory growth. Nature 1983; 306: 70-73.
9. Klein MC, Hutchins PM, Lymangrover JR, Gruber KA. Pressor and cardioaccelerator effects of gamma MSH and related peptides. Life Sci 1985; 36: 769-775.
10. Li SJ, Varga K, Archer P, Hruby VJ, Sharma SD, Kesterson RA, Cone RD, Kunos G. Melanocortin antagonist define two distinct pathways of cardiovascular control by alpha- and gamma-melanocyte-stimulating hormones. J Neurosci 1996; 16: 5182-5188.
11. Van Bergen P, Janssen PM, Hoogerhout P, De Wildt DJ, Versteeg DH. Cardiovascular effects of gamma-MSH/ACTH-like peptides: structure-activity relationship. Eur J Pharmacol 1995; 294: 795-803.
12. Ramaekers D, Beckers F, Demeulemeester H, Bert C, Denef C, Aubert AE. Effects of melanocortins on cardiovascular regulation in rats. Clin Exp Pharmacol Physiol 2002; 29: 549-558.
13. Stanley SA, Davies S, Small CJ, Gardiner JV, Ghatei MA, Smith DM, Bloom SR. gamma-MSH increases intracellular cAMP accumulation and GnRH release in vitro and LH release in vivo. FEBS Lett 2003; 543: 66-70.
14. Ni XP, Pearce D, Butler AA, Cone RD, Humphreys MH. Genetic disruption of gamma-melanocyte-stimulating hormone signaling leads to salt-sensitive hypertension in the mouse. J Clin Invest 2003; 111: 1251-1258.
15. Klusa V, Svirskis S, Opmane B, Muceniece R, Wikberg JE. Behavioural responses of gamma-MSH peptides administered into the rat ventral tegmental area. Acta Physiol Scand 1999; 167: 99-104.
16. Cragnolini A, Scimonelli T, Celis ME, Schioth HB. The role of melanocortin receptors in sexual behavior in female rats. Neuropeptides 2000; 34: 211-215.
17. Xia Y, Wikberg JE, Krukoff TL. Gamma (2)-melanocyte-stimulating hormone suppression of systemic inflammatory responses to endotoxin is associated with modulation of central autonomic and neuroendocrine activities. J Neuroimmunol 2001; 120: 67-77.
18. Getting SJ, Allcock GH, Flower R, Perretti M. Natural and synthetic agonist of the melanocortin receptor type 3 possess anti-inflammatory properties. J Leukoc Biol 2001; 69: 98-104.
19. Tilemans D, Ramaekers D, Andreis M, Denef C. Effect of POMC (1-76), its C-terminal fragment gamma3-MSH and anti-POMC (1 76) antibodies on DNA replication in lactotrophs in aggregate cell cultures of immature rat pituitary. J Neuroendocrinol 1997; 9: 627-637.
20. Matsumura R, Takagi C, Kakeya T, Okuda K, Takeuchi S, Takahashi S. Alpha-melanocyte-stimulating hormone stimulates prolactin secretion through melanocortin-3 receptors expressed in mammotropes in the mouse pituitary. Neuroendocrinology 2003; 78: 96-104.
21. 2+ concentration? J Neuroendocrinol 1999, 11: 171-179.
22. Langouche L, Roudbaraki M, Pals K, Denef C. Stimulation of intracellular free calcium in GH3 cells by gamma3-melanocyte-stimulating hormone. Involvement of a novel melanocortin receptor? Endocrinology 2001; 142: 257-266.
23. Al Obeidi F, Castrucci AM, Hadley ME, Hruby VJ. Potent and prolonged acting cyclic lactam analogues of alpha-melanotropin: design based on molecular dynamics. J Med Chem 1989; 32: 2555-2561.
24. Langouche L, Pals K, Denef C. Structure-activity relationship and signal transduction of gamma-MSH peptides in GH3 cells: further evidence for a new melanocortin receptor. Peptides 2002; 23: 1077-1086.
25. Lu J, Swinnen E, Proost P, De Vreese B, Vankelecom H, Denef C. Isolation and structure-bioactivity characterization of glycosylated N-pro-opiomelanocortin isoforms. J Neuroendocrinol 2002; 14: 869-879.
26. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I, Barsh GS. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 1997; 278: 135-138.
27. Tilemans D, Andries M, Proost P, Devreese B, Van Beeumen J, Denef C. In vitro evidence that an 11-kilodalton N-terminal fragment of proopiomelanocortin is a growth factor specifically stimulating the development of lactotrophs in rat pituitary during postnatal life. Endocrinology 1994; 135: 168-174.
28. Baes M, Denef C. Evidence that stimulation of growth hormone release by epinephrine and vasoactive intestinal peptide is based on cell-to-cell communication in the pituitary. Endocrinology 1987; 120: 280-290.
29. Hauspie A, Seuntjens E, Vankelecom H, Denef C. Stimulation of combinatorial expression of prolactin and glycoprotein hormone alpha-subunit genes by gonadotropin-releasing hormone and estradiol-17beta in single rat pituitary cells during aggregate cell culture. Endocrinology 2003; 144: 388-399.
30. Van Bael A, Vande VV, Devreese B, Van Beeumen J, Denef C. N-terminal 10- and 12-kDa POMC fragments stimulate differentiation of lactotrophs. Peptides 1996; 17: 1219-1228.
31. Cools J, Bilhou-Nabera C, Wlodarska I, Cabrol C, Talmant P, Bernard P, Hagemeijer A, Marynen P. Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11 q12;p13). Blood 1999; 94: 1820-1824.
32. Nelson C, Crenshaw EB III, Franco R, Lira SA, Albert VR, Evans RM, Rosenfeld MG. Discrete cis-active genomic sequences dictate the pituitary cell type-specific expression of rat prolactin and growth hormone genes. Nature 1986; 322: 557-562.
33. Chhajlani V. Distribution of cDNA for melanocortin receptor subtypes in human tissues. Biochem Mol Biol Int 1996; 38: 73-80.
34. Hill JB, Lacy ER, Nagy GM, Gorcs TJ, Frawley LS. Does alpha-melanocyte-stimulating hormone from the pars intermedia regulate suckling-induced prolactin release? Supportive evidence from morphological and functional studies. Endocrinology 1993; 133: 2991-2997.
35. Ellerkmann E, Nagy GM, Frawley LS. Alpha-melanocyte-stimulating hormone is a mammotrophic factor released by neurointermediate lobe cells after estrogen treatment. Endocrinology 1992; 130: 133-138.
36. Watanobe H, Schioth HB, Izumi J. Pivotal roles of alpha-melanocyte-stimulating hormone and the melanocortin 4 receptor in leptin stimulation of prolactin secretion in rats. J Neurochem 2003; 85: 338-347.
37. Lloyd RV. Estrogen-induced hyperplasia and neoplasia in the rat anterior pituitary gland. An immunohistochemical study. Am J Pathol 1983; 113: 198-206.
38. Maurer RA. Estradiol regulates the transcription of the prolactin gene. J Biol Chem 1982; 257: 2133-2136.
39. Scully KM, Gleiberman AS, Lindzey J, Lubahn DB, Korach KS, Rosenfeld MG. Role of estrogen receptor-alpha in the anterior pituitary gland. Mol Endocrinol 1997; 11: 674-681.
40. Houben H, Denef C. Bioactive peptides in anterior pituitary cells. Peptides 1994; 15: 547-582.
41. Yang YK, Thompson DA, Dickinson CJ, Wilken J, Barsh GS, Kent SB, Gantz I. Characterization of Agouti-related protein binding to melanocortin receptors. Mol Endocrinol 1999; 13: 148-155.
42. Dhillo WS, Small CJ, Seal LJ, Kim MS, Stanley SA, Murphy KG, Ghatei MA, Bloom SR. The hypothalamic melanocortin system stimulates the hypothalamo-pituitary-adrenal axis in vitro and in vivo in male rats. Neuroendocrinology 2002; 75: 209-216.
43. Hagan MM, Rushing PA, Pritchard LM, Schwartz MW, Strack AM, Van der Ploeg LH, Woods SC, Seeley RJ. Long-term orexigenic effects of AgRP-(83-132) involve mechanisms other than melanocortin receptor blockade. Am J Physiol Regul Integr Comp Physiol 2000; 279: R47-R52.
44. Hermans E. Biochemical and pharmacological control of the multiplicity of coupling at G-protein-coupled receptors. Pharmacol Ther 2003; 99: 25-44.
45. Denef C. Paracrine control of lactotrope proliferative and differentiation. Trends Endocrinol Metab 2003; 14: 188-195.