Hyperfractionated radiotherapy in locally advanced nasopharyngeal cancer: An analysis of 43 consecutive patients

Strahlentherapie und Onkologie

Volumn 180, Issue 7, 2004, Pages 425-433

  Jereczek Fossa, Barbara A ^a   Morra, Anna ^a   DeBraud, Filippo ^a   Alterio, Daniela ^a   Mazzetta, Chiara ^a   Rocca, Andrea ^a   Catalano, Gianpiero ^a   Bianchi, Livia ^a   Pasetti, Marcella ^a   Chiesa, Fausto ^a   Bruschini, Roberto ^a   Orecchia, Roberto ^a,b  

^a EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Altered unconventional fractionation; Chemotherapy; Hyperfractionation; Nasopharyngeal carcinoma; Radiotherapy

Indexed keywords

BLEOMYCIN; CISPLATIN; EPIRUBICIN; FLUOROURACIL;

ADOLESCENT; ADULT; ADVANCED CANCER; AGED; ANEMIA; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER STAGING; CHRONIC OTITIS MEDIA; CLINICAL ARTICLE; CONFERENCE PAPER; DENTAL CARIES; DISEASE COURSE; DOSE TIME EFFECT RELATION; DOSIMETRY; DYSGEUSIA; FEMALE; FEVER; FIBROSIS; FOLLOW UP; HEAD AND NECK CANCER; HUMAN; HYPERFRACTIONATED RADIOTHERAPY; HYPOACUSIS; HYPOTHYROIDISM; JAW MALFORMATION; LEUKOPENIA; LYMPH NODE METASTASIS; MALE; METASTASIS POTENTIAL; MUCOSA INFLAMMATION; NASOPHARYNX CANCER; NAUSEA; PERIODONTAL DISEASE; PROCESS OPTIMIZATION; RADIATION DOSE FRACTIONATION; RANDOMIZATION; SKIN TOXICITY; SURVIVAL; SURVIVAL RATE; SYSTEMIC THERAPY; THROMBOCYTOPENIA; TREATMENT FAILURE; TRISMUS; VOMITING; WEIGHT REDUCTION; XEROSTOMIA;

ADOLESCENT; ADULT; AGED; DOSE FRACTIONATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NASOPHARYNGEAL NEOPLASMS; NEOPLASM STAGING; RADIOTHERAPY; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS;

EID: 4444227675     PISSN: 01797158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00066-004-1202-9     Document Type: Conference Paper

References (70)

1. Al-Sarraf M. Treatment of locally advanced head and neck cancer: historical and critical review. Cancer Control 2002;9:387-99.
2. Al-Sarraf M, LeBlanc M, Giri PGS, et al. Chemo-radiotherapy versus radiotherapy in patients with advanced nasophayngeal cancer: phase III randomized Intergroup study 0099. J Clin Oncol 1998;16:1310-7.
3. Ang KK, Peters LJ, Weber RS, et al. Concomitant boost radiotherapy schedules in the treatment of carcinoma of the oropharynx and nasopharynx. Int J Radiat Oncol Biol Phys 1990;19:1339-45.
4. Beckmann G, Flentje M. [Present status of treatment in nasopharyngeal carcinoma.] Strahlenther Onkol 2003;79:283-91.
5. Bratengeier K. Applications of two-step intensity modulated arc therapy. Strahlenther Onkol 2001;177:394-403.
6. Chan AT, Teo PM, Leung TW, et al. A prospective randomized study of chemotherapy adjunctive to definitive radiotherapy in advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1995;33:560-77.
7. Chan ATC, Teo PML, Ngan RK, et al. Concurrent chemotherapy-radiotherapy compared with radiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: progression-free survival analysis of a phase III randomized trial. J Clin Oncol 2002;20:2038-44.
8. Chi KH, Chang YC, Guo WY, et al. A phase III study of adjuvant chemotherapy in advanced nasopharyngeal carcinoma patients. Int J Radiat Oncol Biol Phys 2002;52:1238-44.
9. Choi KN, Rotman M, Aziz H, et al. Concomitant infusion cisplatin and hyperfractionated radiotherapy for locally advanced nasopharyngeal and paranasal sinus tumors. Int J Radiat Oncol Biol Phys 1997;39:823-9.
10. Chua DTT, Sham JST, Au GKH, et al. Concomitant chemoirradiation for stage III-IV nasopharyngeal carcinoma in Chinese patients: results of a matched cohort analysis. Int J Radiat Oncol Biol Phys 2002;53:334-43.
11. Chua DTT, Sham JST, Choy D, et al. Preliminary report of the Asian-Oceanian Clinical Oncology Association randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. Cancer 1998;83:2270-83.
12. Chua DTT, Sham JST, Wei WI, et al. Control of regional metastasis after induction chemotherapy and radiotherapy for nasopharyngeal carcinoma. Head Neck 2002;24:350-60.
13. Cozzi L, Fogliata A, Lomax A, et al. A treatment planning comparison of 3 D conformal therapy, intensity modulated photon therapy and proton therapy for treatment of advanced head and neck tumours. Radiother Oncol 2001;61:287-97.
14. Erkal HS, Serin M, Cakmak A. Nasopharyngeal carcinomas: analysis of patient, tumor and treatment characteristics determining outcome. Radiother Oncol 2001;61:247-56.
15. Fang FM, Leung SW, Wang CJ, et al. Computed tomography findings of bony regeneration after radiotherapy for nasopharyngeal carcinoma with skull base destruction: implications for local control. Int J Radiat Oncol Biol Phys 1999;44:305-9.
16. Fogliata A, Bolsi A, Cozzi L. Comparative analysis of intensity modulation inverse planning modules of three commercial treatment planning systems applied to head and neck tumor model. Radiother Oncol 2003;66:29-40.
17. Fogliata A, Cozzi L, Bieri S, et al. Critical appraisal of a conformal head and neck cancer irradiation avoiding electron beams and field matching. Int J Radiat Oncol Biol Phys 1999;45:1331-8.
18. Fu KK, Pajak TF, Trotti A, et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: first report of RTOG 9003. Int J Radiat Oncol Biol Phys 2000;48:7-16.
19. Gene E, Hosal AS, Gedikoglu G, et al. Prognostic value of p53, proliferating cell nuclear antigen, and Ki-67 expression in undifferentiated nasopharyngeal carcinoma. Otolaryngol Head Neck Surg 2000;122:868-73.
20. Gross MW, Spahn U, Engenhart-Cabillic R. [Precision of conventional simulation: which extent of accuracy is reachable in head and neck region?] Strahlenther Onkol 2002;178:216-22.
21. Hareyamam M, Sakata K, Shirato H, et al. A prospective randomized comparing neoadjuvant chemotherapy with radiotherapy alone in patients with advanced nasopharyngeal carcinoma. Cancer 2002;94:2217-23.
22. Horiot JC, Bontemps P, van den Bogaert W, et al. Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers: results of the EORTC 22851 randomized trial. Radiother Oncol 1997;44:111-21.
23. Horiot JC, Le-Fur R, NGuyen T, et al. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma: dinal analysis of a randomized trial of the EORTC Cooperative Group of Radiotherapy. Radiother Oncol 1992;25:231-41.
24. Hsiung CY, Yorke ED, Chui CS, et al. Intensity-modulated radiotherapy versus conventional three-dimensional conformal radiotherapy for boost or salvage treatment of nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2002;53:638-47.
25. Huncharek M, Kupelnick B. Combined chemoradiation versus radiation therapy alone in locally advanced nasopharyngeal carcinoma: results of a meta-analysis of 1,528 patients from six randomized trials. Am J Clin Oncol 2002;25:219-23.
26. International Nasopharynx Cancer Study Group. Preliminary results of a randomized trial comparing neoadjuvant chemotherapy (cisplatinum, epirubicin, bleomycin) plus radiotherapy vs radiotherapy alone in stage IV (> or = N2, M0) undifferentiated nasopharyngeal carcinoma: a positive effect on progress-free survival. Int J Radiât Oncol Biol Phys 1996;35:463-9.
27. Jen YM, Hsu WL, Chen CY, et al. Different risk of symptomatic brain necrosis in NPC patients treated with different altered fractionated radiotherapy techniques. Int J Radiat Oncol Biol Phys 2001;51:344-8.
28. Jen YM, Lin YS, Su WF, et al. Dose escalation using twice-daily radiotherapy for nasopharyngeal carcinoma: does heavier dosing result in a happier ending? Int J Radiat Oncol Biol Phys 2002;54:14-22.
29. Jian JJ, Cheng SH, Yu-Chen S, et al. Improvement of local control of T3 and T4 nasopharyngeal carcinoma by hyperfractionated radiotherapy and concomitant chemotherapy. Int J Radiat Oncol Biol Phys 2002;53:344-52.
30. Johansen LV, Grau C, Overgaard J. Squamous cell carcinoma of the nasopharynx: an analysis of treatment results in 149 consecutive patients. Acta Oncol 2001;40:801-9.
31. Kwong D, Sham J, Choy D. Effect of loco-regional control on distant metastatic dissemination in carcinoma of the nasopharynx: an analysis of 1301 patients. Int J Radiat Oncol Biol Phys 1994;30:1029-36.
32. Lai JP, long CL, Hong C, et al. Association between high initial tissue levels of cyclin d1 and recurrence of nasopharyngeal carcinoma. Laryngoscope 2002;112:402-8.
33. Lee AWM, Foo W, Chappell R, et al. Effect of time, dose, and fraction on temporal lobe necrosis following radiotherapy for nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1998;40:35-42.
34. Lee AWM, Sze WM, Fowler JF, et al. Caution on the use of altered fractionation for nasopharyngeal carcinoma. Radiother Oncol 1999;52:207-11.
35. Lee AWM, Sze WM, Yau TK, et al. Retrospective analysis on treating nasopharyngeal carcinoma with accelerated fractionation (6 fractions per weeks) in comparison with conventional fractionation (5 fractions per week): report on 3-year tumor control and normal tissue toxicity. Radiother Oncol 2001;58:121-30.
36. Lee N, Hoffman R, Philips TL, et al. Managing nasopharyngeal carcinoma with intracavitary brachytherapy: one institution's 45 year experience. J Brachyther 2002;1:74-82.
37. Lee N, Xia P, Quivey JM, et al. Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience. Int J Radiat Oncol Biol Phys 2002;53:12-22.
38. Leung SF, Kreel WH, Tsao SY. Asymptomatic temporal lobe injury after radiotherapy for nasopharyngeal carcinoma: incidence and determinants. Br J Radiol 1992;65:710-4.
39. Leung TW, Tung SY, Sze WK, et al. Salvage brachytherapy for patients with locally persistent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2000;47:405-12.
40. Leung TW, Tung SY, Sze WK, et al. Salvage radiation therapy for locally recurrent nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2000;48:1331-8.
41. Levendag PC, Lagerwaard FJ, de Pan C, et al. High-dose, high-precision treatment options for boosting cancer of the nasopharynx. Radiother Oncol 2002;63:67-74.
42. Lin JC, Chen KY, Jan JS, et al. Partially hyperfractionated accelerated radiotherapy and concurrent chemotherapy for advanced nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 1996;36:1127-36.
43. Lin JC, Jan JS, Hsu CY, et al. Phase III study of concurrent chemoradiotherapy versus radiotherapy alone for advanced nasopharyngeal carcinoma: positive effect on overall and progression-free survival. J Clin Oncol 2003;21:631-7.
44. Ma J, Mai HQ, Hong MH, et al. Results of a prospective randomized trial comparing neoadjuvant chemotherapy plus radiotherapy alone in patients with locoregionally advanced nasopahryngeal carcinoma. J Clin Oncol 2001;19:1350-7.
45. Mendenhall WM, Villaret DB, Amdur RJ, et al. Planned neck dissection after definitive radiotherapy for squamous cell carcinoma of the head and neck. Head Neck 2002;24:1012-8.
46. Miller AB, Hoogsraten B, Staquet M, et al. Reporting results of cancer treatment. Cancer 1981;47:207-14.
47. Munter MW, Debus J, Hof H, et al. Inverse treatment planning and stereotactic intensity-modulated radiation therapy (IMRT) of the tumor and lymph node levels for nasopharyngeal carcinomas. Description of treatment technique, plan comparison, and case study. Strahlenther Onkol 2002;178:517-23.
48. Newkirk KA, Cullen KJ, Harter KW, et al. Planned neck dissection for advanced primary head and neck malignancy treated with organ preservation therapy: disease control and survival outcomes. Head Neck 2001;23:73-9.
49. Olmi P, Crispino S, Fallai C, et al. Locoregionally advanced carcinoma of the oropharynx: conventional radiotherapy vs. accelerated hyperfractionated radiotherapy vs. concomitant radiotherapy and chemotherapy - a multicenter randomized trial. Int J Radiat Oncol Biol Phys 2003;55:78-92.
50. Ozyar E, Yildz F, Akyol FH, et al. Adjuvant high-dose-rate brachytherapy after external beam radiotherapy in nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2002;52:101-8.
51. Perez CA, Brady LW. Quantification of treatment toxicity. In: Perez CA, Brady LW, eds. Principles and practice of radiation oncology. Philadelphia: Lippincott, 1992:51-5.
52. Perez CA, Devineni VR, Marcial-Vega V, et al. Carcinoma of nasopharynx: factors affecting prognosis. Int J Radiat Biol Phys 1992;23:271-80.
53. Poulsen MG, Denham JW, Peters LJ, et al. A randomized trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck: a Trans Tasman Radiation Oncology Group study. Radiother Oncol 2001;60:113-22.
54. Rossi A, Molinari R, Boracchi P, et al. Adjuvant chemotherapy with vincristine, cyclophosphamide, and doxorubicin after radiotherapy in local-regional nasopharyngeal cancer: results of a 4-year multicenter randomized study. J Clin Oncol 1988;6:1401-10.
55. Roy S, Tibesar RJ, Daly K, et al. Role of planned neck dissection for advanced metastatic disease in tongue base or tonsil squamous cell carcinoma treated with radiotherapy. Head Neck 2002;24:474-81.
56. Sanchiz F, Milla A, Torner J, et al. Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer. Int Radiat Oncol Biol Phys 1990;21:557-62.
57. Sanguineti G, Geara FB, Garden AS, et al. Carcinoma of the nasopharynx treated by radiotherapy alone: determinants of local and regional control. Int J Radiat Oncol Biol Phys 1997;37:985-96.
58. Schulz-Ertner D, Didinger B, Nikoghosyan A, et al. Optimization of radiation therapy for locally advanced adenoid cystic carcinomas with infiltration of the skull base using photon. Strahlenther Onkol 2003;179:345-51.
59. Sklodowski K, Maciejewski B, Golen M, et al. Randomized clinical trial on 7-day continuous accelerated irradiation (CAIR) of head and neck - report on 3-year tumor control and normal tissue toxicity. Radiother Oncol 2000;55:101-10.
60. S-PLUS 2000 Professional Release 2. Seattle, Wash.: MathSoft, 1988-1999.
61. Su CK, Wang CC. Prognostic value of Chinese race in nasopharyngeal cancer. Int J Radiat Oncol Biol Phys 2002;54:752-8.
62. Sultaneum K, Shu HK, Xia P, et al. Three-dimensional intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2000;48:711-22.
63. Taama A, Fandi A, Azli N, et al. Phase II trial of chemotherapy with 5-fluorouracil, bleomycin, epirubicin, and cisplatin for patients with locally advanced, metastatic, or recurrent undifferentiated carcinoma of the nasopharyngeal type. Cancer 1999;86:1101-8.
64. Tate DJ, Adler JR Jr, Chang SD, et al. Stereotactic radiosurgical boost following radiotherapy in primary nasopharyngeal carcinoma: impact on local control. Int J Radiat Oncol Biol Phys 1999;45:915-21.
65. Teo PML, Leung SF, Chan ATC, et al. Final report of a randomized trial on altered-fractionated radiotherapy in nasopharyngeal carcinoma prematurely terminated by significant increase in neurological complication. Int J Radiat Oncol Biol Phys 2000;48:1311-22.
66. Therneau TM, Grambsch PM. Modeling survival data. Berlin-Heidelberg-New York: Springer, 2000.
67. Toita T, Ogawa K, Kamata M, et al. Hyperfractionated radiotherapy followed by adjuvant chemotherapy for nasopharyngeal cancer: report of seven cases. Jpn J Clin Oncol 1999;29:160-3.
68. Wang CC. Accelerated hyperfractionation radiation therapy for carcinoma of the nasopharynx: techniques and results. Cancer 1989;63:2461-7.
69. Wolden SL, Zelefsky MJ, Kraus DH, et al. Accelerated concomitant boost radiotherapy and chemotherapy for advanced nasopharyngeal carcinoma. J Clin Oncol 2001;19:1105-10.
70. Xiao JP, Xu GZ, Miao YJ. Fractionated Stereotactic radiosurgery for 50 patients with recurrent or residual nasopharyngeal carcinoma. Int J Radiat Oncol Biol Phys 2001;51:164-70.