Locoregionally advanced carcinoma of the oropharynx: Conventional radiotherapy vs. accelerated hyperfractionated radiotherapy vs. concomitant radiotherapy and chemotherapy - A multicenter randomized trial

International Journal of Radiation Oncology Biology Physics

Volumn 55, Issue 1, 2003, Pages 78-92

  Olmi, Patrizia ^a   Crispino, Sergio ^b   Fallai, Carlo ^c,l   Torri, Valter ^d   Rossi, Francesca ^a   Bolner, Andrea ^e   Amichetti, Maurizio ^e   Signor, Marco ^f   Taino, Raffaella ^g   Squadrelli, Massimo ^g   Colombo, Alessandro ^h   Ardizzoia, Alessandro ^h   Ponticelli, Pietro ^b   Franchin, Giovanni ⁱ   Minatel, Emilio ⁱ   Gobitti, Carlo ⁱ   Atzeni, Guido ^j   Gava, Alessandro ^k   Flann, Monica ^d   Marsoni, Silvia ^d  

^a UNIVERSITY OF FLORENCE   (Italy)

^b IRCCS POLICLINICO SAN DONATO   (Italy)

^c Rep di Radioterapia   (Italy)

^d Ist di Ricerche Farmacol M Negri   (Italy)

^e SANTA CHIARA HOSPITAL   (Italy)

^f Azienda Ospedaliero Universitaria Santa Maria della Misericordia   (Italy)

^g OSPEDALI RIUNITI   (Italy)

^h AO S Gerardo   (Italy)

ⁱ CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^j Spedali Riuniti   (Italy)

^k OSPEDALE CA FONCELLO   (Italy)

^l NATIONAL CANCER INSTITUTE   (Italy)

more..

Author keywords

Advanced squamous cell oropharyngeal carcinoma; Altered fractionation; Concomitant radiochemotherapy; Radiation therapy; Randomized Phase III trial

Indexed keywords

CHEMOTHERAPY; PATIENT TREATMENT; TOXICITY; TUMORS;

CONCOMITANT CHEMOTHERAPY (CT);

RADIOTHERAPY;

CARBOPLATIN; FLUOROURACIL;

ADULT; ADVANCED CANCER; AGED; ANEMIA; ARTICLE; CANCER CHEMOTHERAPY; CANCER PALLIATIVE THERAPY; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; FOLLOW UP; HUMAN; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; METASTASIS; MUCOSA INFLAMMATION; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; NEPHROTOXICITY; OROPHARYNX CARCINOMA; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; RADIATION; RADIATION DOSE; RADIATION INJURY; RANDOMIZED CONTROLLED TRIAL; SKIN MANIFESTATION; THROMBOCYTOPENIA; TREATMENT FAILURE; TREATMENT OUTCOME; XEROSTOMIA;

ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; COMBINED MODALITY THERAPY; DOSE FRACTIONATION; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOPLASM STAGING; OROPHARYNGEAL NEOPLASMS; PALLIATIVE CARE; PATIENT COMPLIANCE; RADIOTHERAPY; SALVAGE THERAPY; SURVIVAL RATE;

EID: 0346037191     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0360-3016(02)03792-6     Document Type: Article

References (57)

1. Million R.R. Cancer of the head and neck. De Vita V.T., Hellman S., Rosenberg S.A. Principles and Practice of Oncology. 4th Ed. 1992;396-420 Lippincott-Raven, Philadelphia.
2. Olmi P., Cellai E., Chiavacci A., et al. Results of curative radiotherapy in oropharyngeal carcinomas. Rays. 11:1985;138-139.
3. Sanchiz F., Milla' A., Torner J., et al. Single fraction per day versus two fractions per day versus radiochemotherapy in the treatment of head and neck cancer. Int J Radiat Oncol Biol Phys. 21:1990;557-562.
4. Pinto L.H.J., Canary P.C.V., Araujo C.M.M., et al. Prospective randomized trial comparing hyperfractionated versus conventional radiotherapy in stages III and IV oropharyngeal carcinoma. Int J Radiat Oncol Biol Phys. 21:1991;557-562.
5. Horiot J.C., Le Fur R., N'Guyen T., et al. Hyperfractionation versus conventional fractionation in oropharyngeal carcinoma Final analysis of a randomized trial of the EORTC cooperative group of radiotherapy . Radiother Oncol. 25:1992;231-241.
6. Wang C.C. Local control of oropharyngeal carcinoma after two accelerated hyperfractionation radiation therapy schemes. Int J Radiat Oncol Biol Phys. 14:1988;1143-1146.
7. Gehanno P., Depondt J., Peynegre R., et al. Neoadjuvant combination of carboplatin and 5-FU in head and neck cancer A randomised study . Ann Oncol. 3:(Suppl. 3):1992;43-46.
8. Vokes E., Weichselbaum R.R. Concomitant chemoradiotherapy Rationale and clinical experience in patients with solid tumors . J Clin Oncol. 8:1989;911-934.
9. Adelstein D.J., Sharan V.M., Earle A.S., et al. Long-term results after radiochemotherapy for locally confined squamous-cell head and neck cancer. Am J Clin Oncol. 13:1990;440-447.
10. Merlano M., Vitale V., Rosso R., et al. Treatment of advanced squamous-cell carcinoma of the head and neck. N Engl J Med. 327:1992;1115-1121.
11. Taylor S.G. IV, Murthy A.K., Vannetzel J.M., et al. Randomized comparison of neoadjuvant cisplatin and fluorouracil infusion followed by radiation versus concomitant treatment in advanced head and neck cancer. J Clin Oncol. 12:1994;385-395.
12. Christian M.C. Carboplatin. Principles and Practice of Oncology Updates. 3rd Ed. 1989;1-16 Lippincott, Philadelphia.
13. Muggia F.M. Overview of carboplatin Replacing, complementing, and extending the therapeutic horizons of cisplatin . Semin Oncol. 16:(Suppl. 5):1989;7-13.
14. Tsuchiya K., Nishioka T., Shirato H., et al. A randomized trial of concomitant chemoradiotherapy for head and neck cancers Cisplatin (CDDP) vs. carboplatin (CBDCA) . Int J Radiat Oncol Biol Phys. 51:2001;337. (Abstr.).
15. Eisenberger M., Van Echo D., Aisner J. Carboplatin, the experience in head and neck cancer. Semin Oncol. 16:(Suppl. 5):1989;34-41.
16. Knox R.J., Friedlos F., Lydall D.A., et al. Mechanism of cytotoxicity of anticancer platinum drugs Evidence that cis-diamminedichloroplatinum (II) and cis-diammine-(1,1-cyclobutanedicarboxylato) platinum (II) differ only in the kinetics of their interaction with DNA . Cancer Res. 46:1986;1972-1979.
17. O'Hara J.A., Douple E.B., Richmond R.C. Enhancement of radiation-induced cell kill by platinum complexes (carboplatin and iproplatin) in V79 cells. Int J Radiat Oncol Biol Phys. 12:1986;1419-1422.
18. Zamboglou N., Pape H., Schnabel T., et al. Combined radiotherapy with cis- or carboplatin in advanced head and neck tumors. Strahlenther Onkol. 165:1989;647-651.
19. Colombo A., Crispino S., Tancini G., et al. Radiotherapy plus a combination of cisplatin and 5-fluorouracil for locally advanced head and neck neoplasms. Study of feasibility and preliminary results. Radiol Med (Torino). 80:1990;713-718.
20. Weaver A., Fleming S., Vandenberg H., et al. Cis-platinum and 5-fluorouracil as initial therapy in advanced epidermoid cancers of the head and neck. Head Neck Surg. 4:1982;370-373.
21. TNM Classification of Malignant Tumors. 4th Ed. 1989;Springer, New York.
22. Wang C.C., Efird J., Nakfoor B., et al. Local control of T3 carcinomas after accelerated fractionation - a look at the gap. Int J Radiat Oncol Biol Phys. 32:1995;889-890.
23. Perez C.A., Brady L.W., Roti J.L. Overview. Perez C.A., Brady L.W. Principles and Practice of Radiation Oncology. 4th Ed. 1992;1-63 Lippincott-Raven, Philadelphia.
24. Handbook for Reporting Results of Cancer Treatment. 1979;WHO, Geneva. WHO offset publication no. 48.
25. Beck-Bornholdt H.P., Dubben H.H., Liertz-Petersen C., et al. Hyperfractionation Where do we stand? Radiother Oncol. 43:1997;1-21.
26. Olmi P., Fallai C. Nonstandard fractionation schedules in radiation therapy of head and neck cancer A review . Tumori. 83:1997;633-642.
27. Olmi P., Fallai C. Randomized trials on altered fractionation in head and neck cancer radiotherapy with conventional fractionation as control arm Another lap to go . Tumori. 84:1998;160-166.
28. Stuschke M., Thames H.D. Hyperfractionated radiotherapy of human tumors Overview of the randomized clinical trials . Int J Radiat Oncol Biol Phys. 37:1997;259-267.
29. Stuschke M., Thames H.D. Hyperfractionation Where do we stand? Radiother Oncol. 46:1998;131-133.
30. Horiot J.C., Begg A.C., Le Fur R., et al. Present status of EORTC trials of hyperfractionated and accelerated radiotherapy on head and neck carcinoma. Recent Results Cancer Res. 134:1994;111-119.
31. Horiot J.C., Bontemps P., van den Bogaert W., et al. Accelerated fractionation (AF) compared to conventional fractionation (CF) improves loco-regional control in the radiotherapy of advanced head and neck cancers Results of the EORTC 22851 randomized trial . Radiother Oncol. 44:1997;111-121.
32. Fu K.K., Pajak T.F., Trotti A., et al. A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas First report of RTOG 9003 . Int J Radiat Oncol Biol Phys. 48:2000;7-16.
33. Mackenzie R.G., Hodson D.I., Browman G.P., et al. Hyperfractionated Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck. 2000;. Cancer Care Ontario practice guideline initiative CPG 5_6b, november. http. //www.hiru.mcmaster.ca/ccopgi/guidelines/head/cpg5_6b.html.
34. Mackenzie R.G., Hodson D.I., Browman G.P., et al. Accelerated Radiotherapy for Locally Advanced Squamous Cell Carcinoma of the Head and Neck. 2000;. Cancer Care Ontario practice guideline initiative CPG 5_6c, november. http. //www.hiru.mcmaster.ca/ccopgi/guidelines/head/cpg5_6c.html.
35. Skladowski K., Maciejewski B., Golen M., et al. Randomized clinical trial on 7-day-continuous accelerated irradiation (CAIR) of head and neck cancer - report on 3-year tumour control and normal tissue toxicity. Radiother Oncol. 55:2000;101-110.
36. Munro A.J. An overview of randomized controlled trials of adjuvant chemotherapy in head and neck cancer. Br J Cancer. 71:1995;83-91.
37. Browman G.P., Hodson D.I., Mackenzie R.G., et al. Concomitant Chemotherapy and Radiotherapy in Squamous Cell Head and Neck Cancer (excluding nasopharynx). 2000;. Cancer Care Ontario practice guideline initiative CPG 5_6a, update march. http. //www.hiru.mcmaster.ca/ccopgi/guidelines/head/cpg5_6a.html.
38. Browman G.P., Hodson D.I., Mackenzie R.G., et al. Choosing a concomitant chemotherapy and radiotherapy regimen for squamous cell head and neck cancer A systematic review of the published literature with subgroups analysis . Head Neck. 23:2001;579-589.
39. Pignon J.P., Bourhis J., Domenge C., et al. Chemotherapy added to locoregional treatment for head and neck squamous cell carcinoma Three meta-analyses of updated individual data. MACH-NC Collaborative Group. Meta-analysis of chemotherapy on head and neck cancer . Lancet. 355:2000;949-955.
40. Bourhis J., Calais G., Eschwège F. Chimioradiotherapie des carcinomes des voies aerodigestives superieurs. Cancer Radiother. 2:1998;679-688.
41. Pignon J.P., Baujat B., Hill C., et al. Locally advanced head and neck cancer Meta-analysis of updated individual data . Eur J Cancer. 37:(Suppl. 6):2001;135. (Abstr.).
42. Adelstein D.J., Saxton J.P., Lavertu P., et al. A phase III randomized trial comparing concurrent chemotherapy and radiotherapy with radiotherapy alone in resectable stage III and IV squamous cell head and neck cancer Preliminary results . Head Neck. 19:1997;567-575.
43. Adelstein DJ, Adams GL, Li Y; et al. A Phase III Comparison of Standard Radiation Therapy (RT) Versus RT Plus Concurrent Cisplatin (Ddp) Versus Split-course RT Plus Concurrent Ddp and 5-Fu (5fu) in Patients with Unresectable Squamous Cell Head and Neck Cancer (SCHNC): An Intergroup Study (Abstr.). http.//www.asco.org/prof/me/html/00abstracts/hnc/m_1624.html.
44. Haddad E., Mazeron J.J., Martin M., et al. Comparison of concomitant radiotherapy and chemotherapy with radiotherapy alone in cancers of the head and neck Result of a randomized trial . Bull Cancer Radiother. 83:1996;97-103.
45. Calais G., Alfonsi M., Bardet E., et al. Radiation alone (RT) versus RT with concomitant chemotherapy (CT) in stages III and IV oropharynx carcinoma. Final results of the 94-01 Gortec Randomized Study (Abstr.). Int J Radiat Oncol Biol Phys. 51:(Suppl. 1):2001;1.
46. Merlano M., Benasso M., Corvo' R., et al. Five-year update of a randomized trial of alternating radiotherapy and chemotherapy compared with radiotherapy alone in treatment of unresectable squamous cell carcinoma of the head and neck. J Natl Cancer Inst. 88:1996;583-589.
47. Garden AS, Pajak TF, Vokes E; et al. Preliminary Results of RTOG 9703 - A Phase II Randomized Trial of Concurrent Radiation (RT) and Chemotherapy for Advanced Squamous Cell Carcinomas (SCC) of the Head and Neck (Abstr.) http.//www.asco.org/prof/me/html/01/abstracts/0023/891.htm.
48. Budach V., Haake K., Stuchke M., et al. Radiochemotherapy is more effective than dose escalation in locally advanced head and neck cancer Results of a German multicentre randomized trial . Eur J Cancer. 37:(Suppl. 6):2001;10. (Abstr.).
49. Dobrowsky W., Naude J. Continuous hyperfractionated accelerated radiotherapy with/without mitomycin C in head and neck cancers. Radiother Oncol. 57:2000;119-124.
50. Sailer S.L., Weissler M.C., Melin S.A., et al. Toxicity and preliminary results from a trial of hyperfractionated radiation with or without simultaneous 5-fluorouracil-cisplatin in advanced head and neck squamous cell carcinomas. Semin Radiat Oncol. 2:1992;38-40.
51. Wendt T.G., Grabenhauer G.G., Rodel C.M., et al. Simultaneous radiochemotherapy versus radiotherapy alone in advanced head and neck cancer A randomized multicenter study . J Clin Oncol. 16:1998;1318-1324.
52. Brizel D.M., Albers M.E., Fisher S.R., et al. Hyperfractionated irradiation with or without concurrent chemotherapy for locally advanced head and neck cancer. N Engl J Med. 338:1998;1798-1804.
53. Staar S., Rudat V., Stuetzer H., et al. Intensified hyperfractionated accelerated radiotherapy limits the additional benefit of simultaneous chemotherapy - results of a multicentric randomized German trial in advanced head and neck cancer. Int J Radiat Oncol Biol Phys. 50:2001;1161-1171.
54. Keane T.J., Cummings B.J., O'Sullivan B., et al. A randomised trial of radiation therapy compared to split course radiation therapy combined with mitomycin C and 5 fluorouracil as initial treatment for advanced laryngeal and hypopharyngeal squamous carcinoma. Int J Radiat Oncol Biol Phys. 25:1993;613-618.
55. Brizel D.M. Radiotherapy and concurrent chemotherapy for the treatment of locally advanced head and neck squamous cell carcinoma. Semin Radiat Oncol. 8:1998;237-246.
56. Henk J.M. Controlled trials of synchronous chemotherapy with radiotherapy in head and neck cancer Overview of radiation morbidity . Clin Oncol (R Coll Radiol). 9:1997;308-312.
57. Poulsen M.G., Denham J.W., Peters L.J., et al. A randomized trial of accelerated and conventional radiotherapy for stage III and IV squamous carcinoma of the head and neck: A Trans Tasman Radiation Oncology Group Study. Radiother Oncol. 60:2001;113-122.