Degradation of circulating von Willebrand factor and its regulator ADAMTS13 implicates secreted Bacillus anthracis metalloproteases in anthrax consumptive coagulopathy

Journal of Biological Chemistry

Volumn 283, Issue 15, 2008, Pages 9531-9542

  Chung, Myung Chul ^a   Popova, Taissia G ^a   Jorgensen, Shelley C ^a   Dong, Li ^a   Chandhoke, Vikas ^a   Bailey, Charles L ^a   Popov, Serguei G ^a  

^a GEORGE MASON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; AMINES; AMINO ACIDS; BACTERIOLOGY; BLOOD SUBSTITUTES; COAGULATION; ORGANIC ACIDS; PLASMAS; PLATELETS; THEOREM PROVING; UREA;

AMINO ACID SEQUENCING; ANIMAL MODELS; ANTHRAX SPORES; BACILLUS ANTHRACIS; CLEAVAGE SITES; COLLAGEN BINDINGS; DO-MAINS; FUNCTIONAL ACTIVITIES; HUMAN PLASMAS; INTRAVASCULAR; LEUCOPENIA; METALLO PROTEASES; NEW MECHANISMS; PLATELET AGGREGATIONS; REGULATORY PROTEINS; RISTOCETIN; SIGNIFICANT REDUCTIONS; TARGET DOMAINS; THROMBOCYTOPENIA; TOXIGENIC; VASCULAR PERMEABILITIES; VON WILLEBRAND FACTORS; WESTERN BLOTS;

ENDOTHELIAL CELLS;

COLLAGEN; METALLOPROTEINASE; METALLOPROTEINASE INHA; METALLOPROTEINASE NPR599; RISTOCETIN; UNCLASSIFIED DRUG; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ADAM PROTEIN; ADAMTS13 PROTEIN, HUMAN; ADAMTS13 PROTEIN, MOUSE; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; UREA;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTHRAX; ARTICLE; BACILLUS ANTHRACIS; BINDING AFFINITY; BLEEDING; CELL INTERACTION; CONTROLLED STUDY; DISSEMINATED INTRAVASCULAR CLOTTING; HEMOSTASIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; QUANTITATIVE ANALYSIS; THROMBOCYTE; THROMBOCYTE AGGREGATION; THROMBOSIS; WESTERN BLOTTING; ANIMAL; BACTERIAL SPORE; CELL COMMUNICATION; DISEASE MODEL; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME SPECIFICITY; ENZYMOLOGY; LEUKOPENIA; METABOLISM; MICROBIOLOGY; PATHOLOGY; PLASMA; PROTEIN TERTIARY STRUCTURE; THROMBOCYTOPENIA; TIME;

ANIMALIA; BACILLUS ANTHRACIS; MUS;

ADAM PROTEINS; ANIMALS; ANTHRAX; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BLOOD PLATELETS; CELL COMMUNICATION; COLLAGEN; DISEASE MODELS, ANIMAL; DISSEMINATED INTRAVASCULAR COAGULATION; ENDOTHELIAL CELLS; HEMOSTASIS; HUMANS; LEUKOPENIA; METALLOENDOPEPTIDASES; METALLOPROTEASES; MICE; PLASMA; PLATELET AGGREGATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RISTOCETIN; SPORES, BACTERIAL; SUBSTRATE SPECIFICITY; THROMBOCYTOPENIA; THROMBOSIS; TIME FACTORS; UREA; VON WILLEBRAND FACTOR;

EID: 44349186815     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M705871200     Document Type: Article

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