Platelet aggregates as markers of platelet activation: Characterization of flow cytometric method suitable for clinical applications

American Journal of Hematology

Volumn 57, Issue 1, 1998, Pages 33-42

  Jy, Wenche ^a   Horstman, Lawrence L ^a   Park, Haejoe ^a   Mao, Wei Wei ^a   Valant, Peter ^a   Ahn, Yeon S ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Platele aggregates; Platelet activation; Platelet leukocyte interaction

Indexed keywords

ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CELL POPULATION; COLLAGEN SYNTHESIS; DIAGNOSTIC TEST; ENDOTHELIUM CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

BIOLOGICAL MARKERS; BLOOD PLATELETS; DEAMINO ARGININE VASOPRESSIN; FLOW CYTOMETRY; HUMANS; LEUKOCYTES; P-SELECTIN; PLATELET ACTIVATION; PLATELET AGGREGATION; PURPURA, THROMBOCYTOPENIC;

EID: 0031974303     PISSN: 03618609     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8652(199801)57:1<33::AID-AJH6>3.0.CO;2-2     Document Type: Article

References (40)

1. Joseph M, ed: "Immunopharmacology of Platelets." New York: Academic Press, 1995.
2. Colman RW, Cook JJ, Niewiarowski S: Mechanisms of platelet aggregation. In Coleman RW, Hirsh J, Marder VJ, Salzman EW (eds): "Hemostasis and Thrombosis: Basic Principles and Clinical Practice," 3rd ed. Philadelphia: JB Lippincott Company, 1994, pp 508-524.
3. Siess W: Molecular mechanisms of platelet activation. Physiol Rev. 69:58-178, 1989.
4. Born GV: Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 194:927-929, 1962.
5. Faint RW: Platelet-neutrophil interactions: Their significance. Blood Rev 6:83-91, 1992.
6. Dinerman JL, Mehta JL: Endothelial, platelet and leukocyte interactions in ischemic heart disease: Insights into potential mechanisms and their clinical relevance. J Am Coll Cardiol. 16:207-222, 1990.
7. Ault KA, Rinder HM, Mitchell JG, Rinder CS, Lambrew CT, Hillman RS: Correlated measurement of platelet release and aggregation in whole blood. Cytometry. 10:448-455, 1989.
8. Gait SW, Mc Daniel MD, Ault KA, Mitchell J, Cronenwett JL: Flow cytometric assessment of platelet function in patients with peripheral arterial occlusive disease. J Vasc Surg. 14:747-756, 1991.
9. Rinder HM, Bonan JL, Rinder CS, Ault KA, Smith BR: Activated and unactivated platelet adhesion to monocytes and neutrophils. Blood, 78:1760-1769, 1991.
10. Jy W, Horstman LL, Arce M, Ahn YS: Clinical significance of platelet microparticles in ITP. J Lab Clin Med 119:334, 1992.
11. Lee Y, Jy W, Horstman LL, Ahn YS. Elevated platelet microparticles in TIA, lacunar infarcts, and multiinfarct dementias. Thromb Res. 72:295, 1993.
12. Katopodis JN, Kolodny L, Jy W, Horstman LL, de Marchena EJ, Tao JG, Haynes DH, Ahn YS: Platelet microparticles and calcium homeostasis in acute coronary ischemias. Am J Hematol 54:95, 1997.
13. Ozner MD, Ahn YS, Horstman LL, Jy W, Myerburg RJ: Chronic platelet activation associated with acute coronary syndromes in 13 middle aged patients. Clin Appl Thromb/Hemost 3:46, 1997.
14. Kolodny L, Ahn YS, Sheremata WA: Evidence of platelet activation in multiple sclerosis. Presented at the 121st meeting of the Am Neurol Assoc, Miami, FL. Ann Neurol 40:520(Abstr M117), 1996.
15. Jy W, Horstman L, Park H, Mao W, Kolodny L, Ahn YS. Flowcytometric assay of platelet aggregates in whole blood: Detection of effects of TTP plasma and DDAVP. Blood 86(Suppl 1):899a, 1995.
16. Ahn YS, Jy W, Kolodny L, Mao WW, Valant P, Horstman LL: Activated platelet aggregates in thrombotic thrombocytopenic purpura: Decrease with plasma infusions and normalization in remission. Br J Haematol 95:408-415, 1996.
17. Horstman LL, Valle-Riestra BJ, Jy W, Wang F, Mao W, Ahn YS: Desmopressin (DDAVP) acts on platelets to generate microparticles and enhanced procoagulant activity. Thromb Res 79:163-174, 1995.
18. Lian EC-Y, Harkness DR, Byrnes JJ, Wallach H, Nunez R: Presence of platelet aggregating factor in the plasma of patients with TTP and its inhibition by normal plasma. Blood 53:333-338, 1979.
19. Lian, EC-Y, Siddiqui FA, Chen S-H, Feng L-M: Platelet-agglutinating/aggregating proteins from the plasma of patients with thrombotic thrombocytopenic purpura. In Kaplan BS, Trompeter RS, Moake JL (eds): "Hemolytic Uremic Syndrome and Thrombotic Thrombocytopenic Purpura." New York: Marcel Dekker, Inc., 1992, pp 437-481.
20. Rinder CS, Bonan JL, Rinder HM, Mathew J, Hines R, Smith BR. Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood. 79:1201-1205, 1992.
21. Patarroyo M: Leukocyte adhesion in host defense and tissue injury. Clin Immunol Immunopathol. 60:333-348, 1991.
22. Verrier ED, Shen I: Potential role of neutrophil anti-adhesion therapy in myocardial stunning, myocardial infarction, and organ dysfunction after cardiopulmonary bypass. J Cardiac Surg. 8:309-312, 1993.
23. Von Andrian UH, Arfores KE. Neutrophil-endothelial cell interactions in vivo: A chain of events characterized by distinct molecular mechanisms. Agents Actions (Supp 1) 41:153-164, 1993.
24. Ruf A, Schlenk RF, Maras A, Morgenstern E, Patscheke H. Contact-induced neutrophil activation by platelets in human cell suspensions and whole blood. Blood, 80:1238-1246, 1992.
25. Rhee B-G, Hall ER, McIntire LV. Platelet modulation of polymorpho nuclear leukocytes shear induced aggregation. Blood. 67:240-246, 1986.
26. Molino M, Blanchard N, Belmonte E, Tarver AP, Abrams C, Hoxie JA, Cerletti C, Brass LF: Proteolysis of the human platelet and endothelial cell thrombin receptor by neutrophil-derived cathepsin G. J Biol Chem. 270:11168-11175, 1995.
27. Larsen E, Cell A, Gilbert GE, Furie BC, Erban JK, Bonfanti R, Wagner DD, Furie B. PADGEM protein: A receptor that mediates the interaction of activated platelets with neutrophils and monocytes. Cell. 59:305-312, 1989.
28. Hamburger SA, McEver RP. GMP-140 mediates the adhesion of stimulated platelets to neutrophils. Blood. 75:550-554, 1990.
29. Larsen E, Palabrica T, Sajer S, Gilbert GE, Wagner DD, Furie BC, Furie B. PADGEM-dependent adhesion of platelets to monocytes and neutrophils is mediated by a lineage-specific carbohydrate, LNF III (CD15). Cell. 63:467-484, 1990.
30. Policy MJ, Phillips ML, Wayner E, Nudelman E, Singhai AK, Hakomori S-I, Paulson JC. CD62 and endothelial cell-leukocyte adhesion molecule 1 (ELAM-1) recognize the same carbohydrate ligand, sialyl-Lewis x. Proc Natl Acad Sci USA. 88:6224-6228, 1991.
31. Wu KK, Hoak JC: A new method for the quantitation and detection of platelet aggregation in patients with arterial insufficiency. Lancet II. 924-926, 1974.
32. Wu KK, Hoak JC: Spontaneous platelet aggregation in arterial insufficiency: Mechanism and implications. Thromb Haemost. 35:702-711, 1976.
33. Wedzicha JA, Syndercombe-Court D, Tan KC: Increased platelet aggregate formation in patients with chronic airflow obstruction and hypoxaemia. Thorax. 46:504-509, 1991.
34. Collins CE, Cahill MR, Newland AC, Rampton DS: Platelets circulate in an activated state in inflammatory bowel disease. Gastroenterology. 166:840-845, 1994.
35. Dougherty JH Jr, Levy DE, Weksler BB: Experimental cerebral ischemia produces platelet aggregates. Neurology. 29:1460-1465, 1979.
36. Daniel WG, Nellessen U, Schroder E, et al: Left atrial spontaneous echo contrast in mitral valve disease: An indicator for an increased thromboembolic risk. J Am Coll Cardiol. 11:1204-1211, 1988.
37. Mahony C, Sublett KL, Harrison MR: Resolution of spontaneous contrast with platelet disaggregatory therapy (trifluoperazine). Am J Cardiol. 63:1009-1010, 1989.
38. Valant P, Jy W, Horstman L, Mao W, Ahn YS: Increased leukocyte binding and P selectin expression in platelet aggregates induced by TTP plasma. Clin Res 44:327(A), 1996.
39. Valant P, Jy W, Horstman LL, Mao W, Kolodny L, Ahn YS: Leukocyte binding of platelet aggregates (PAg) in thrombotic thrombocytopenic purpura (TTP) and heparin induced thrombocytopenia with thrombosis (HITT). Presented at 4th Eur Symp Platelet Granulocyte Immunobiol, Hameenlinna, Finland, May 18-21, 1996.
40. Sevush S, Jy W, Horstman LL, Mailla RS, Mao WW, Ahn YS: Platelet activation in Alzheimer's disease. Arch Neurol 1997 (in press).