Challenging the cardiac differentiation of bone marrow cells: A clinical perspective

Molecular Therapy

Volumn 16, Issue 6, 2008, Pages 1000-1001

  Menasché, Philippe ^a  

^a HÔPITAL EUROPÉEN GEORGES POMPIDOU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ACTININ; CD45 ANTIGEN; CYTOKINE; STEM CELL FACTOR RECEPTOR; VOLTAGE GATED CALCIUM CHANNEL; VOLTAGE GATED SODIUM CHANNEL;

ANGIOGENESIS; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL SURVIVAL; CLINICAL EFFECTIVENESS; CLINICAL TRIAL; EVOKED RESPONSE; EXTRACELLULAR MATRIX; HEART EJECTION FRACTION; HEART INFARCTION; HEART MUSCLE REPERFUSION; HUMAN; LASER MICROSCOPY; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; NOTE; PARACRINE SIGNALING; PHENOTYPE; TREATMENT INDICATION; TWO PHOTON LASER SCANNING MICROSCOPY;

EID: 44349165815     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2008.75     Document Type: Note

References (20)

1. Orlic D, Kajstura J, Chimenti S, Jakoniuk I, Anderson SM, Li B et al. (2001). Bone marrow cells regenerate infarcted myocardium. Nature 410: 701-705.
2. Murry CE, Soonpaa MH, Reinecke H, Nakajima H, Nakajima HO, Rubart M et al. (2004). Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428: 664-666.
3. Balsam LB, Wagers AJ, Christensen JL, Kofidis T, Weissman IL and Robbins RC (2004). Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428: 668-673.
4. Nygren JM, Jovinge S, Breitbach M, Säwén P, Röll W, Hescheler J et al. (2004). Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med 10: 494-501.
5. Scherschel JA, Soonpa MH, Srour EF, Field LJ and Rubart M (2008). Adult bone marrow-derived cells do not acquire functional attributes of cardiomyocytes upon transplantation into peri-infarct myocardium. Mol Ther 16: 1129-1137.
6. Lagostena L, Avitabile D, De Falco E, Orlandi A, Grassi F, Iachininoto M et al. (2005). Electrophysiological properties of mouse bone marrow c-kit cells co-cultured onto neonatal cardiac myocytes. Cardiovasc Res 66: 482-492.
7. Kinnaird T, Stabile E, Burnett MS, Lee CW, Barr S, Fuchs S et al. (2004). Marrow-derived stromal cells express genes encoding a broad spectrum of arteriogenic cytokines and promote in vitro and in vivo arteriogenesis through paracrine mechanisms. Circ Res 94: 678-685.
8. + stem cells for intractable angina: A phase I/IIa double-blind, randomized controlled trial. Circulation 115: 3165-3172.
9. Assmus B, Fischer-Rasokat U, Honold J, Seeger FH, Fichtlscherer S, Tonn T et al. (2007). TOPCARE-CHD Registry. Transcoronary transplantation of functionally competent BMCs is associated with a decrease in natriuretic peptide serum levels and improved survival of patients with chronic postinfarction heart failure: Results of the TOPCARE-CHD Registry. Circ Res 100: 1234-1241.
10. Ryan JM, Barry FP, Murphy JM and Mahon BP (2005). Mesenchymal stem cells avoid allogeneic rejection. J Inflamm (Lond) 2: 8.
11. St John Sutton M, Pfeffer MA, Plappert T, Rouleau JL, Moyé LA, Dagenais GR et al. (1994). Quantitative two dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction: The protective effects of captopril. Circulation 89: 68-75.
12. Uemura R, Xu M, Ahmad N and Ashraf M (2006). Bone marrow stem cells prevent left ventricular remodeling of ischemic heart through paracrine signaling. Circ Res 98: 1414-1421.
13. Lipinski MJ, Biondi-Zoccai GG, Abbate A, Khianey R, Sheiban I, Bartunek J et al. (2007). Impact of intracoronary cell therapy on left ventricular function in the setting of acute myocardial infarction. J Am Coll Cardiol 50: 1761-1767.
14. Hendrikx M, Hensen K, Clijsters C, Jongen H, Koninckx R, Bijnens E et al. (2006). Recovery of regional but not global contractile function by the direct intramyocardial autologous bone marrow transplantation: results from a randomized controlled clinical trial. Circulation 114(1 Suppl): I101-I107.
15. + bone marrow cells and coronary artery bypass grafting for chronic ischemic heart disease: safety and efficacy studies. J Thorac Cardiovasc Surg 133: 717-725.
16. Assmus B, Honold J, Schachinger V, Britten MB, Fischer-Rasokat U, Lehmann R et al. (2006). Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med 355 1222-1232.
17. Pouly J, Bruneval P, Mandet C, Proksch S, Peyrard S, Amrein C et al. (2008). Cardiac stem cells in the real world. J Thorac Cardiovasc Surg 135: 673-678.
18. Tomescot A, Leschik J, Bellamy V, Dubois G, Messas E, Bruneval P et al. (2007). Differentiation in vivo of cardiac committed human embryonic stem cells in post-myocardial infarcted rats. Stem Cells 25: 2200-2205.
19. Kehat I, Khimovich L, Caspi O, Gepstein A, Shofti R, Arbel G et al. (2004). Electromechanical integration of cardiomyocytes derived from human embryonic stem cells. Nat Biotechnol 22: 1282-1289.
20. Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marban E et al. (2005). Functional integration of electrically active cardiac derivatives from genetically engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation 111: 11-20.