메뉴 건너뛰기




Volumn 21, Issue 6, 2008, Pages 670-675

Epigenetic instability is rare in fibrolamellar carcinomas but common in viral-associated hepatocellular carcinomas

Author keywords

Fibrolamellar carcinoma; Hepatocellular carcinoma; HPP1; Methylation; RASSF1A; Viral hepatitis

Indexed keywords

CATENIN CADHERIN ASSOCIATED PROTEIN BETA 1; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; GLUTATHIONE TRANSFERASE P1; PROTEIN HPP1; PROTEIN P16; PROTEIN P53; PROTEIN RARA; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; SUPPRESSOR OF CYTOKINE SIGNALING 1; TUMOR SUPPRESSOR PROTEIN; UVOMORULIN;

EID: 44349154093     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2008.32     Document Type: Article
Times cited : (28)

References (33)
  • 1
    • 27144486411 scopus 로고    scopus 로고
    • Clinicopathologic features and survival in fibrolamellar carcinoma: Comparison with conventional hepatocellular carcinoma with and without cirrhosis
    • Kakar S, Burgart LJ, Batts KP, et al. Clinicopathologic features and survival in fibrolamellar carcinoma: comparison with conventional hepatocellular carcinoma with and without cirrhosis. Mod Pathol 2005;18:1417-1423.
    • (2005) Mod Pathol , vol.18 , pp. 1417-1423
    • Kakar, S.1    Burgart, L.J.2    Batts, K.P.3
  • 2
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • Farazi PA, DePinho RA. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer 2006;6:674-687.
    • (2006) Nat Rev Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 3
    • 33645214725 scopus 로고    scopus 로고
    • Review of genetic and epigenetic alterations in hepatocarcinogenesis
    • Herath NI, Leggett BA, MacDonald GA. Review of genetic and epigenetic alterations in hepatocarcinogenesis. J Gastroenterol Hepatol 2006;21:15-21.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. 15-21
    • Herath, N.I.1    Leggett, B.A.2    MacDonald, G.A.3
  • 4
    • 0034601378 scopus 로고    scopus 로고
    • Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients
    • Marchio A, Pineau P, Meddeb M, et al. Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients. Oncogene 2000;19:3733-3738.
    • (2000) Oncogene , vol.19 , pp. 3733-3738
    • Marchio, A.1    Pineau, P.2    Meddeb, M.3
  • 5
    • 0742283964 scopus 로고    scopus 로고
    • Fibrolamellar hepatocellular carcinoma occurring 5 years after hepatocellular adenoma in a 14-year-old girl: A case report with comparative genomic hybridization analysis
    • Terracciano LM, Tornillo L, Avoledo P, et al. Fibrolamellar hepatocellular carcinoma occurring 5 years after hepatocellular adenoma in a 14-year-old girl: a case report with comparative genomic hybridization analysis. Arch Pathol Lab Med 2004;128:222-226.
    • (2004) Arch Pathol Lab Med , vol.128 , pp. 222-226
    • Terracciano, L.M.1    Tornillo, L.2    Avoledo, P.3
  • 6
    • 0034525791 scopus 로고    scopus 로고
    • Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization
    • Wilkens L, Bredt M, Flemming P, et al. Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization. Am J Clin Pathol 2000;114:867-874.
    • (2000) Am J Clin Pathol , vol.114 , pp. 867-874
    • Wilkens, L.1    Bredt, M.2    Flemming, P.3
  • 7
    • 16244387945 scopus 로고    scopus 로고
    • Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation
    • Kannangai R, Wang J, Liu QZ, et al. Survivin overexpression in hepatocellular carcinoma is associated with p53 dysregulation. Int J Gastrointest Cancer 2005;35:53-60.
    • (2005) Int J Gastrointest Cancer , vol.35 , pp. 53-60
    • Kannangai, R.1    Wang, J.2    Liu, Q.Z.3
  • 8
    • 15144343103 scopus 로고    scopus 로고
    • p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation
    • Honda K, Sbisa E, Tullo A, et al. p53 mutation is a poor prognostic indicator for survival in patients with hepatocellular carcinoma undergoing surgical tumour ablation. Br J Cancer 1998;77:776-782.
    • (1998) Br J Cancer , vol.77 , pp. 776-782
    • Honda, K.1    Sbisa, E.2    Tullo, A.3
  • 9
    • 0033547371 scopus 로고    scopus 로고
    • Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas
    • Terris B, Pineau P, Bregeaud L, et al. Close correlation between beta-catenin gene alterations and nuclear accumulation of the protein in human hepatocellular carcinomas. Oncogene 1999;18:6583-6588.
    • (1999) Oncogene , vol.18 , pp. 6583-6588
    • Terris, B.1    Pineau, P.2    Bregeaud, L.3
  • 10
    • 33947149044 scopus 로고    scopus 로고
    • Fibrolamellar carcinomas show over expression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways
    • Kannangai R, Vivekanandan P, Martinez-Murillo F, et al. Fibrolamellar carcinomas show over expression of genes in the RAS, MAPK, PIK3, and xenobiotic degradation pathways. Hum Pathol 2007;38:639-644.
    • (2007) Hum Pathol , vol.38 , pp. 639-644
    • Kannangai, R.1    Vivekanandan, P.2    Martinez-Murillo, F.3
  • 11
    • 33644642358 scopus 로고    scopus 로고
    • DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma
    • Park HJ, Yu E, Shim YH. DNA methyltransferase expression and DNA hypermethylation in human hepatocellular carcinoma. Cancer Lett 2006;233:271-278.
    • (2006) Cancer Lett , vol.233 , pp. 271-278
    • Park, H.J.1    Yu, E.2    Shim, Y.H.3
  • 12
    • 13144290928 scopus 로고    scopus 로고
    • Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma
    • Yu J, Zhang H, Gu J, et al. Methylation profiles of thirty four promoter-CpG islands and concordant methylation behaviours of sixteen genes that may contribute to carcinogenesis of astrocytoma. BMC Cancer 2004;4:65.
    • (2004) BMC Cancer , vol.4 , pp. 65
    • Yu, J.1    Zhang, H.2    Gu, J.3
  • 13
    • 3042707323 scopus 로고    scopus 로고
    • Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis
    • Yu J, Ni M, Xu J, et al. Methylation profiling of twenty promoter-CpG islands of genes which may contribute to hepatocellular carcinogenesis. BMC Cancer 2002;2:29.
    • (2002) BMC Cancer , vol.2 , pp. 29
    • Yu, J.1    Ni, M.2    Xu, J.3
  • 14
    • 0042575343 scopus 로고    scopus 로고
    • Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms
    • Fukushima N, Sato N, Sahin F, et al. Aberrant methylation of suppressor of cytokine signalling-1 (SOCS-1) gene in pancreatic ductal neoplasms. Br J Cancer 2003;89:338-343.
    • (2003) Br J Cancer , vol.89 , pp. 338-343
    • Fukushima, N.1    Sato, N.2    Sahin, F.3
  • 15
    • 33645453248 scopus 로고    scopus 로고
    • Epigenetic instability and chromosomal instability in hepatocellular carcinoma
    • Katoh H, Shibata T, Kokubu A, et al. Epigenetic instability and chromosomal instability in hepatocellular carcinoma. Am J Pathol 2006;168:1375-1384.
    • (2006) Am J Pathol , vol.168 , pp. 1375-1384
    • Katoh, H.1    Shibata, T.2    Kokubu, A.3
  • 16
    • 28544440377 scopus 로고    scopus 로고
    • Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia
    • Chim CS, Wong SY, Pang A, et al. Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia. Leukemia 2005;19:2241-2246.
    • (2005) Leukemia , vol.19 , pp. 2241-2246
    • Chim, C.S.1    Wong, S.Y.2    Pang, A.3
  • 17
    • 0036894567 scopus 로고    scopus 로고
    • Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma
    • Sato F, Shibata D, Harpaz N, et al. Aberrant methylation of the HPP1 gene in ulcerative colitis-associated colorectal carcinoma. Cancer Res 2002;62:6820-6822.
    • (2002) Cancer Res , vol.62 , pp. 6820-6822
    • Sato, F.1    Shibata, D.2    Harpaz, N.3
  • 18
    • 0034075153 scopus 로고    scopus 로고
    • Hypermethylation of multiple genes in pancreatic adenocarcinoma
    • Ueki T, Toyota M, Sohn T, et al. Hypermethylation of multiple genes in pancreatic adenocarcinoma. Cancer Res 2000;60:1835-1839.
    • (2000) Cancer Res , vol.60 , pp. 1835-1839
    • Ueki, T.1    Toyota, M.2    Sohn, T.3
  • 19
    • 27144448810 scopus 로고    scopus 로고
    • Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1
    • Lee JO, Kwun HJ, Jung JK, et al. Hepatitis B virus X protein represses E-cadherin expression via activation of DNA methyltransferase 1. Oncogene 2005;24:6617-6625.
    • (2005) Oncogene , vol.24 , pp. 6617-6625
    • Lee, J.O.1    Kwun, H.J.2    Jung, J.K.3
  • 20
    • 33645976174 scopus 로고    scopus 로고
    • Ubiquitous activation of Ras and Jak/Stat pathways in human HCC
    • Calvisi DF, Ladu S, Gorden A, et al. Ubiquitous activation of Ras and Jak/Stat pathways in human HCC. Gastroenterology 2006;130:1117-1128.
    • (2006) Gastroenterology , vol.130 , pp. 1117-1128
    • Calvisi, D.F.1    Ladu, S.2    Gorden, A.3
  • 21
    • 18144411303 scopus 로고    scopus 로고
    • Role of the Ras-association domain family 1 tumor suppressor gene in human cancers
    • Agathanggelou A, Cooper WN, Latif F. Role of the Ras-association domain family 1 tumor suppressor gene in human cancers. Cancer Res 2005;65:3497-3508.
    • (2005) Cancer Res , vol.65 , pp. 3497-3508
    • Agathanggelou, A.1    Cooper, W.N.2    Latif, F.3
  • 22
    • 0036789450 scopus 로고    scopus 로고
    • High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma
    • Zhang YJ, Ahsan H, Chen Y, et al. High frequency of promoter hypermethylation of RASSF1A and p16 and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma. Mol Carcinog 2002;35:85-92.
    • (2002) Mol Carcinog , vol.35 , pp. 85-92
    • Zhang, Y.J.1    Ahsan, H.2    Chen, Y.3
  • 23
    • 0041695472 scopus 로고    scopus 로고
    • Intensive hypermethylation of the CpG island of Ras association domain family 1A in hepatitis B virus-associated hepatocellular carcinomas
    • Zhong S, Yeo W, Tang MW, et al. Intensive hypermethylation of the CpG island of Ras association domain family 1A in hepatitis B virus-associated hepatocellular carcinomas. Clin Cancer Res 2003;9:3376-3382.
    • (2003) Clin Cancer Res , vol.9 , pp. 3376-3382
    • Zhong, S.1    Yeo, W.2    Tang, M.W.3
  • 24
    • 34547729171 scopus 로고    scopus 로고
    • Promoter hypermethylation of the RASSF1A gene predicts the poor outcome of patients with hepatoblastoma
    • Sugawara W, Haruta M, Sasaki F, et al. Promoter hypermethylation of the RASSF1A gene predicts the poor outcome of patients with hepatoblastoma. Pediatr Blood Cancer 2006;49:240-249.
    • (2006) Pediatr Blood Cancer , vol.49 , pp. 240-249
    • Sugawara, W.1    Haruta, M.2    Sasaki, F.3
  • 25
    • 33745088298 scopus 로고    scopus 로고
    • Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver
    • Di Gioia S, Bianchi P, Destro A, et al. Quantitative evaluation of RASSF1A methylation in the non-lesional, regenerative and neoplastic liver. BMC Cancer 2006;6:89.
    • (2006) BMC Cancer , vol.6 , pp. 89
    • Di Gioia, S.1    Bianchi, P.2    Destro, A.3
  • 26
    • 33744745285 scopus 로고    scopus 로고
    • Promoter methylation and response to chemotherapy and radiation in esophageal cancer
    • Hamilton JP, Sato F, Greenwald BD, et al. Promoter methylation and response to chemotherapy and radiation in esophageal cancer. Clin Gastroenterol Hepatol 2006;4:701-708.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 701-708
    • Hamilton, J.P.1    Sato, F.2    Greenwald, B.D.3
  • 27
    • 33745693216 scopus 로고    scopus 로고
    • Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel
    • Brucher BL, Geddert H, Langner C, et al. Hypermethylation of hMLH1, HPP1, p14(ARF), p16(INK4A) and APC in primary adenocarcinomas of the small bowel. Int J Cancer 2006;119:1298-1302.
    • (2006) Int J Cancer , vol.119 , pp. 1298-1302
    • Brucher, B.L.1    Geddert, H.2    Langner, C.3
  • 28
    • 33644686386 scopus 로고    scopus 로고
    • Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers
    • Ebert MP, Mooney SH, Tonnes-Priddy L, et al. Hypermethylation of the TPEF/HPP1 gene in primary and metastatic colorectal cancers. Neoplasia 2005;7:771-778.
    • (2005) Neoplasia , vol.7 , pp. 771-778
    • Ebert, M.P.1    Mooney, S.H.2    Tonnes-Priddy, L.3
  • 29
    • 27644455870 scopus 로고    scopus 로고
    • DNA methylation- associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers
    • Suzuki M, Shigematsu H, Shames DS, et al. DNA methylation- associated inactivation of TGFbeta-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers. Br J Cancer 2005;93:1029-1037.
    • (2005) Br J Cancer , vol.93 , pp. 1029-1037
    • Suzuki, M.1    Shigematsu, H.2    Shames, D.S.3
  • 30
    • 0037108915 scopus 로고    scopus 로고
    • Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas
    • Shibata DM, Sato F, Mori Y, et al. Hypermethylation of HPP1 is associated with hMLH1 hypermethylation in gastric adenocarcinomas. Cancer Res 2002;62:5637-5640.
    • (2002) Cancer Res , vol.62 , pp. 5637-5640
    • Shibata, D.M.1    Sato, F.2    Mori, Y.3
  • 31
    • 0035793108 scopus 로고    scopus 로고
    • HPP1: A transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers
    • Young J, Biden KG, Simms LA, et al. HPP1: a transmembrane protein-encoding gene commonly methylated in colorectal polyps and cancers. Proc Natl Acad Sci USA 2001;98:265-270.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 265-270
    • Young, J.1    Biden, K.G.2    Simms, L.A.3
  • 32
    • 0038339107 scopus 로고    scopus 로고
    • Age-related methylation of tumor suppressor and tumor-related genes: An analysis of autopsy samples
    • Waki T, Tamura G, Sato M, et al. Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples. Oncogene 2003;22:4128-4133.
    • (2003) Oncogene , vol.22 , pp. 4128-4133
    • Waki, T.1    Tamura, G.2    Sato, M.3
  • 33
    • 33748653168 scopus 로고    scopus 로고
    • Emerging drugs for hepatocellular carcinoma
    • Roberts LR, Gores GJ. Emerging drugs for hepatocellular carcinoma. Expert Opin Emerg Drugs 2006;11:469-487.
    • (2006) Expert Opin Emerg Drugs , vol.11 , pp. 469-487
    • Roberts, L.R.1    Gores, G.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.