Sequence-structure-function analysis of the bifunctional enzyme MnmC that catalyses the last two steps in the biosynthesis of hypermodified nucleoside mnm5s2U in tRNA

Proteins: Structure, Function and Genetics

Volumn 71, Issue 4, 2008, Pages 2076-2085

  Roovers, Martine ^a   Oudjama, Yamina ^a   Kaminska, Katarzyna H ^b,c   Purta, Elzbieta ^b,d   Caillet, Joël ^e   Droogmans, Louis ^f   Bujnicki, Janusz M ^b,c  

^a Institut de Recherches Microbiologiques J M Wiame   (Belgium)

^b INTERNATIONAL INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Poland)

^c ADAM MICKIEWICZ UNIVERSITY   (Poland)

^d INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

^e INST DE BIOLOGIE PHYSICO CHIMIQUE   (France)

^f UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Domain fusion; Flavoprotein; Methyltransferase; Modified nucleosides; tRNA; Wobble position

Indexed keywords

5 METHYLAMINOMETHYL 2 THIOURIDINE; ENZYME; ENZYME MNMC; ENZYME RSMC; TRANSFER RNA; URIDINE DERIVATIVE;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; BINDING AFFINITY; BIOSYNTHESIS; CATALYSIS; ESCHERICHIA COLI; GENOME; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; BINDING SITES; CATALYSIS; COMPUTATIONAL BIOLOGY; CONSERVED SEQUENCE; ELECTROSTATICS; ESCHERICHIA COLI PROTEINS; FLAVIN-ADENINE DINUCLEOTIDE; GENETIC COMPLEMENTATION TEST; LIGANDS; METHYLATION; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIENZYME COMPLEXES; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RNA, BACTERIAL; RNA, TRANSFER; SEQUENCE ANALYSIS; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP; THIOURIDINE;

ESCHERICHIA;

EID: 44349146074     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.21918     Document Type: Article

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