Induction of thyroid and liver tumors by chronic exposure to 2-methylimidazole in F344/N rats and B6C3F1 mice

Archives of Toxicology

Volumn 82, Issue 6, 2008, Pages 399-412

  Chan, P C ^a   Sills, R C ^a   Kissling, G E ^a   Nyska, A ^a   Richter, W ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b SOUTHERN RESEARCH INSTITUTE   (United States)

Author keywords

2 Methylimidazole; Granuloma; Liver; Mice; Rats; Thyroid; Tumors

Indexed keywords

2 METHYLIMIDAZOLE; GLUCURONOSYLTRANSFERASE; IMIDAZOLE DERIVATIVE; LIOTHYRONINE; THYROTROPIN; THYROXINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CARCINOGENIC ACTIVITY; CELL PROLIFERATION; CHRONIC INFLAMMATION; CONTROLLED STUDY; FEMALE; HEMATOPOIETIC CELL; LIOTHYRONINE BLOOD LEVEL; LIVER ADENOMA; LIVER CELL CARCINOMA; LONG TERM EXPOSURE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; SURVIVAL RATE; THYROID ADENOMA; THYROID FOLLICLE CELL; THYROID FOLLICULAR CARCINOMA; THYROID HORMONE BLOOD LEVEL; THYROID HYPERPLASIA; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL;

ADENOCARCINOMA; ADENOMA; ADMINISTRATION, ORAL; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GLUCURONOSYLTRANSFERASE; IMIDAZOLES; LIVER; LIVER NEOPLASMS; MALE; MICE; MICE, INBRED C57BL; ORGAN SIZE; RATS; RATS, INBRED F344; THYROID HORMONES; THYROID NEOPLASMS; THYROTROPIN;

ANIMALIA; MUS; NICOTIANA TABACUM; RATTUS;

EID: 44349142726     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-007-0249-7     Document Type: Article

References (42)

1. Boegel LB, Cook JC, O'Connor JC, Aschiero M, Arduengo AJ III, Slone TW (1995) Subchronic toxicity study in rats with 1-methyl-3-propylimidazole-2- thione (PTI): effects on the thyroid. Fundam Appl Toxicol 27:185-194
2. Capen CC (1997) Mechanistic data and risk assessment of selected toxic end points of the thyroid gland. Toxicol Pathol 25:39-48
3. Chan P, Mahler J, Travlos G, Nyska A, Wenk M (2006) Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice. Arch Toxicol 80:169-180
4. Chemical Economics Handbook (1995) Online. Dialog. 359. Bibliographic database
5. Comer CP, Chengelis CP, Levin S, Kotsonis FN (1985) Changes in thyroidal function and liver UDP-glucuronosyltransferase activity in rats following administration of a novel imidazole. Toxicol Appl Pharmacol 80:427-436
6. Dunn OJ (1964) Multiple comparisons using rank sums. Technometrics 6:241-252
7. Dunnett CW (1955) A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc 50:1096-1121
8. Foley GI (2001) Overview of male reproductive pathology. Toxicol Pathol 29:49-63
9. Haseman JK, Lockhart AM (1993) Correlation between chemically-related site-specific carcinogenic effects in long term studies in rats and mice. Environ Health Perspect 101:50-54
10. Huang Y, Zhang S, Yang R (1983) Survey of communal industrial production of caramel by the ammonium process. Tiaowei Fushipin Keji 3:11-12 (Abstract)
11. Huff JE, Cirvello J, Haseman J, Bucher J (1991) Chemicals associated with site-specific neoplasia in 1394 long-term carcinogenesis experiments in laboratory rodents. Environ Health Perspect 93:247-270
12. Johnson JD, Reichelderfer DR, Zutshi A, Graves S, Walters D, Smith C (2002) Toxicokinetics of 2-methylimidazole in male and female F344 rats. J Toxicol Environ Health A 65:869-879
13. MaConnell EE (1992) Thyroid follicular cell carcinogenesis results from 343 two year carcinogenicity studies conducted by the NCI/NTP. Regul Toxicol Pharmacol 16:177-188
14. Matyasovszky P, Jeszenszky Z (1985) Determination of caramels in wines by gel chromatography and gas chromatography. Borgazdasag 33:105-110 (Abstract only)
15. McClain RM (1989) The significance of hepatic microsomal enzyme induction and altered thyroid function in rats: implications for thyroid gland neoplasia. Toxicol pathol 17:294-306
16. McClain RM (1992) Thyroid gland neoplasia: non-genotoxic mechanisms. Toxicol Lett 64/65:397-408
17. McClain RM, Rice JM (1999) A mechanistic relationship between thyroid follicular cell tumours and hepatocellular neoplasms in rodents. IARC 147:61-67
18. Moree-Testa P, Saint-Jalm Y, Testa A (1984) Identification and determination of imidazole derivatives in cigarette smoke. J Chromatog 290:263-274
19. Morgan SE, Edwards WC (1986) Pilot studies in cattle and mice to determine the presence of 4-methylimidazole in milk after oral ingestion. Vet Hum Toxicol 28:240-242
20. Muller L, Sivertsen T, Langseth W (1998) Ammoniated forage poisoning: concentrations of alkylimidazoles in ammoniated forage and in milk, plasma and urine in sheep and cow. Acta Vet Scand 39:511-514
21. NTP National Toxicology Program (2004) Toxicology and carcinogenesis studies of 2-methylimidazole in F344/n rats and B6C3F1 mice. NTP Technical Report Series No. 516. US Department of Health and Human Services, Public Health Service, National Institutes of Health
22. Nishie k, Waiss AC Jr, Keyl AC (1969) Toxicity of methylimidazoles. Toxicol Appl Pharmacol 14:301-307
23. Nishie K, Waiss AC Jr, Keyl AC (1970) Pharmacology of alkyl and hydroxyalkylpyrazines. Toxicol Appl Pharmacol 17:244-249
24. Ohta K, Yamaguchi J, Akimoto M, Fukushima K, Suwa T, Awazu S (1996) Retention mechanism of imidazoles in connective tissue. I. Binding to elastin. Drug Metab Dispos 24:1291-1297
25. Ohta K, Fukasawa Y, Yamaguchi J, Akimoto M, Kohno Y, fukushima K, Suwa T, Awazu S (1998a) Retention mechanism of imiazoles in connective tissue. III. Aldehyde adduct formation of a 4(5H)(or 5(4H))-imidazolone product in vitro. Biol Pharm Bull 21:958-963
26. Ohta K, Fukasawa Y, Yamaguchi J, Kohno Y, Fukushima K, Suwa T, Awzu S (1998b) Retention mechanism of imidazoles in connective tissue. IV. Identification of a nucleophilic imidazolone metabolite in rats Biol Pharm Bull 21:1334-1337
27. Perdok HB, Leng RA (1987). Hyperexcitability in cattle fed ammoniated roughages. Anim Feed Sci Technol 17:121-143
28. Ray AC, Raisor MJ, Herd DB, Murphy MJ, Reagor JC (1984) Methylimidazole content of ammoniated forages associated with toxicity in cattle. Am Assoc Vet Lab Diagnosticians 27th Annual Proceedings, pp 337-348
29. Sakuma H, Kusama M, Yamaguchi K, Matsuki T, Sugawara S (1984) The distribution of cigaret smoke components between mainstream and sidestream smoke. II Bases Beitr Tabakforsch Int 22:199-209 (Abstract only)
30. Sanders JM, Griffin RJ, Burka LT, Matthews HB (1998) Disposition of 2-methylimidazole in rats. J Toxicol Environ Health A 54:121-132
31. Shirley E (1977) A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment. Biometrics 33:386-389
32. Tani Y, Foster PM, Sills RC, Chan PC, Peddada SD, Nyska A (2005) Epididymal sperm granuloma induced by chronic administration of 2-methylimidazole in B6C3F1 mice. Toxicol Pathol 33:1-7
33. Taurog A (1976) The mechanism of action of the thiourylene antithyroid drugs. Endocrinol 98:1031-1046
34. Technical Resources Inc (1991) Summary of data for chemical selection-2-methylimidazole. Prepared for the National Cancer Institute, contract N01-CP-56019. NIEHS, Research Triangle Park, NC
35. Temple AR, Done AK, Clement MS (1971) Studies of glucuronidation: III. The measurement of apunitrophenyl glucuronide. J Lab Clin Med 77:1015-1019
36. Weiss WP, Conrad HR, Martin CM, Cross RF, Shockey W (1986) Etiology of ammoniated hay toxicosis. J Anim Sci 63:525-532
37. Wiggins LF (1956) Some recent studies on ammoniated molasses. Sugar J 18:18-20
38. Williams DA (1971) A test for differences between treatment means when several dose levels are compared with a zero dose control. Biometrics 27:103-117
39. Williams DA (1972) The comparison of several dose levels with a zero dose control. Biometrics 28:519-531
40. Williams DA (1986) A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control. Biometrics 42:183-186
41. Wong JM, Bernhard RA (1988) Effect of nitrogen source on pyrazine formation. J Agric Food Chem 36:123-129
42. Yoshikawa S, Fijiwara M (1981) Determination of 4(5)-methylimidazole in food by thin layer chromatography. J Food Hyg Soc Jpn 22:189-196 (Abstract only)