Induction of thyroid lesions in 14-week toxicity studies of 2 and 4-methylimidazole in Fischer 344/N rats and B6C3F1 mice

Archives of Toxicology

Volumn 80, Issue 3, 2006, Pages 169-180

  Chan, Po ^a   Mahler, Joel ^a   Travlos, Greg ^a   Nyska, Abraham ^a   Wenk, M ^b  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^b Microbiological Associates Inc   (United States)

Author keywords

2 And 4 methylimidazole; Mice; Rats; Thyroid lesions

Indexed keywords

2 METHYLIMIDAZOLE; 4 METHYLIMIDAZOLE; IMIDAZOLE DERIVATIVE; LIOTHYRONINE; THYROTROPIN; THYROXINE; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATAXIA; ATROPHY; CELL HYPERPLASIA; CELL PROLIFERATION; CELL VACUOLE; CONTROLLED STUDY; DRUG MEGADOSE; FEMALE; FOOD CONTAMINATION; GOITER; HEMATOPOIETIC CELL; HISTOPATHOLOGY; HYPERTROPHY; HYPOPHYSIS; INCIDENCE; KIDNEY DISEASE; KIDNEY TUBULE; LIOTHYRONINE BLOOD LEVEL; LIVER CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE; RAT; SPLEEN; TESTIS ATROPHY; THYROID DISEASE; THYROID FOLLICLE CELL; THYROID FOLLICULAR CARCINOMA; THYROID HYPERPLASIA; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; TOXICITY TESTING; TREMOR;

ACUTE TOXICITY TESTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPERPLASIA; HYPERTROPHY; IMIDAZOLES; INCIDENCE; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; RATS; RATS, INBRED F344; SEX FACTORS; THYROID DISEASES; THYROXINE; TOXICITY TESTS, CHRONIC; TRIIODOTHYRONINE;

ANIMALIA; ATAXIA;

EID: 33644622454     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-005-0018-4     Document Type: Article

References (36)

1. Atterwill CK, Jones C, Brown CG (1992) Thyroid gland II - mechanisms of species-dependent thyroid toxicity, hyperplasia and neoplasia induced by xenobiotics. Atterwill CK, Flack JD (eds) Endocrine toxicology. Cambridge University Press, London pp 137-182
2. Back DJ, Tija JF (1985) Inhibition of tolbutamide metabolism by substituted imidazol drugs in vivo: evidence for a structure-activity relationship. Br J Pharmacol 85:121-126
3. Chappel CI, Howell JC (1992) Caramel colours - a historical introduction. Fd Chem Toxicol 30:351-357
4. Chemical Economics Handbook [database online] (1995) Diag. 359. Epoxy resins. SRI International, Menlo Park, CA
5. Comer CP, Chengelis CP, Levin S, Kotsonis F (1985) Changes in thyroidal function and liver UDPglucuronosyltransferase activity in rats following administration of a novel imidazole (SC-37211). Toxicol Appl Pharmacol 80:427-436
6. Dunn OJ (1964) Multiple comparisons using rank sums. Technometrics 6:241-252
7. Dunnett CW (1955) A multiple comparison procedure for comparing several treatments with a control. J Am Stat Assoc 50:1096-1121
8. Fairbrother TE, Kerr LA, Essig HW (1987) Effects of 4-methylimidazole in young calves. Vet Hum Toxicol 29:312-315
9. Gart JJ, Cu KC, Tarone RE (1979) Statistical issues in interpretation of chronic bioassay tests for carcinogenicity. J Natl Cancer Inst 62:957-974
10. Hargreaves MB, Jones BC, Smith DA, Gescher A (1994). Inhibition of p-nitrophenol hydroxylase in rat liver microsomes by small aromatic and heterocyclic molecules. Drug Metab Dispos 22:806-810
11. Hill RN, Erdreich SE, Paynter OE, Roberts PA, Rosenthal SL, Wilkinson CF (1989) Thyroid follicular cell carcinogenesis. Fund Appl Toxicol 12:629-697
12. Huang Y, Zhang S, Yang R (1983) Survey of communal industrial production of caramel by the ammonium process (Abstract). Tiaowei Fushipin Keji 3:11-12
13. Mattyasovszky P, Jeszenszky Z (1985) Determination of caramels in wines by gel chromatography and gas chromatography (Abstract). Borgazdasag 33:105-110
14. McClain RM (1992). Thyroid gland neoplasia: non-genotoxic mechamisms. Toxicol Lett 64(65):397-408
15. Moree-Testa P, Saint-Jalm Y, Testa A (1984) Identification and determination of imidazole derivatives in cigarette smoke. J Chromatogr 290:263-274
16. Morgan SE, Edwards WC (1986a) Bovine bonkers: New terminology for an old problem. A review of toxicity associated with ammoniated feeds. Vet Hum Toxicol 28:16-18
17. Morgan SE, Edwards WC (1986b) Pilot studies in cattle and mice to determine the presence of 4-methylimidazole in milk after oral ingestion. Vet Hum Toxicol 28:240-242
18. Nielsen P, Friis C, Kraul I (1993) Disposition of 4-mekthylimidazole in goats and heifers. Res Vet Sci 54:72-79
19. Nishie K, Waiss AC Jr, Keyl AC (1969) Toxicity of methylimidazoles. Toxicol Appl Pharmacol 14:301-307
20. Nishie K, Waiss AC Jr, Keyl AC (1970) Pharmocology of alkyl and hydroxyalkylpyrazines. Toxicol Appl Pharmacol 17:244-249
21. Paynter OE, Burin RB, Jaeger RB, Gregorio CA (1988) Goitrogens and thyroid follicular cell neoplasia: evidence for a threshold process. Reg Toxicol Pharmacol 8:102-119
22. Perdok HB, Leng RA (1987) Hyperexcitability in cattle fed ammoniated roughages. Anim Feed Sci Technol 17:121-143
23. Ray AC, Raisor MJ, Herd DB, Murphy MJ, Reagor JC (1984) Methylimidazole content of ammoniated forages associated with toxicity in cattle. American association of veterinary laboratory Diagnosticians of 27th Annual Proceedings pp 337-348
24. Sakuma H, Kusama M, Yamaguchi K, Matsuki T, Sugawara S (1984) The distribution of cigarette smoke components between mainstream and sidestream smoke. II. Bases (Abstract). Beitr Tabakforsch Int 22:199-209
25. Sanders JM, Griffin RJ, Burka LT, Matthews HB (1998) Disposition of 2-methylimidazole in rats. J Toxicol Environ Health Pt A 54:121-132
26. Shirley E (1977) A non-parametric equivalent of Williams' test for contrasting increasing dose levels of a treatment. Biometrics 33:386-389
27. Taurog A (1976) The mechanism of action of thioureylene antithyroid drugs. Endocrinol 98:1031-1046
28. Thomas GA, Williams ED (1991) Evidence for and possible mekchanisms of non-genotoxic carcinogenesis in the rodent thyroid. Mutat Res 248:357-370
29. Waagepetersen J, Vestergaard P, Thomsen K (1977) effects on digestibility and nitrogen content of barley straw of different ammonia treatments. Anim Feed Sci Technol 2:131-142
30. Weiss WP, Conrad HR, Martin CM, Cross RF, Shockey WL (1986) Etiology of ammoniated hay toxicosis. J Anim Sci 63:525-532
31. Wiggins LF (1956) Some recent studies on ammoniated molasses. Sugar J 18:18-20
32. Williams DA (1971) A test for differences between teatment means when several dose levels are compared with a zero dose control. Biometrics 27:103-117
33. Williams DA (1972) The comparison of several dose levels with a zero dose control. Biometics 28:519-531
34. Williams DA (1986) A note on Shirley's nonparametric test for comparing several dose levels with a zero-dose control. Biometics 42:183-186
35. Wong JM, Bernhard RA (1988) Effect of nitrogen source on pyrazine formation. J Agric Food Chem 36:123-129
36. Yoshikawa S, Fijiwara M (1981) Determination of 4(5)-methylimidazole in food by thin layer chromatography (Abstract). J Food Hyg Soc Jap 22:189-196