Disposition of 2-Methylimidazole in rats

Journal of Toxicology and Environmental Health - Part A

Volumn 54, Issue 2, 1998, Pages 121-132

  Sanders, J M ^a   Griffin, R J ^a   Burka, L T ^a   Matthews, H B ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYLIMIDAZOLE; CARBON 14; CARBON DIOXIDE; CIGARETTE SMOKE; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BILIARY EXCRETION; ENTEROHEPATIC CIRCULATION; FECES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION;

ADMINISTRATION, ORAL; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; MALE; METABOLIC CLEARANCE RATE; RATS; RATS, INBRED F344; TISSUE DISTRIBUTION;

ANIMALIA;

EID: 0031711340     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/009841098158953     Document Type: Article

References (21)

1. Back, D. J., and Tjia, J. F. 1985. Inhibition of tolbutamide metabolism by substituted imidazole drugs in vivo: Evidence for a structure-activity relationship. Br. J. Pharmacol. 85:121-126.
2. Biegel, L. B., Cook, J. C., O'Connor, J. C., Aschiero, M., Arduengo, A. J. III, and Slone, T. W. 1995. Subchronic toxicity study in rats with 1- methyl-3-propylimidazole-2-thione (PTI): Effects on the thyroid. Fundam. Appl. Toxicol. 27:185-194.
3. Birnbaum, L. S., Decad, G. M., and Matthews, H. B. 1980. Disposition and excretion of 2,3,7,8-tetra-chlorodibenzofuran in the rat. Toxicol. Appl. Pharmacol. 55:342-352.
4. Chan, P. C., and Wenk, M. L. 1995. Ninety-day toxicity studies of 2-methylimidazole in Fischer rats and B6C3F1 mice. Toxicologist 15:202.
5. Chan, P. C., and Wenk, M. L. 1996. Comparative 90-day toxicity studies of 2- and 4-methylimida-zole in Fischer rats and B6C3F1 mice. Toxicologist 30:1035.
6. Chemical Economics Handbook. 1995. Online. Dialog. 359. Bibliographic database.
7. Dierickx, P. J. 1989. Cytotoxicity testing of 114 compounds by the determination of the protein content in hep G2 cell cultures. Toxicol. In Vitro 3:189-193.
8. Fairbrother, T. E., Kerr, L. A., and Essig, H. W. 1987. Effects of 4-methylimidazole in young calves. Vet. Hum. Toxicol. 29:312-315.
9. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. 1951. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193:265-275.
10. Matthews, H. B., and Anderson, M. W. 1975. The distribution and excretion of 2,4,5,2',5'-pen- tachlorobiphenyl in the rat. Drug Metab. Dispos. 3:211-219.
11. Moree-Testa, P., Saint-Jalm, Y., and Testa, A. 1984. Identification and determination of imidazole derivatives i n cigarette smoke. J. Chromatogr. 290:263-274.
12. Morgan, S. E., and Edwards, W. C. 1986. Pilot studies in cattle and mice to determine the presence of 4-methylimidazole in milk after oral ingestion. Vet. Hum. Toxicol. 28:240-242.
13. Nishie, K., Waiss, A. C., Jr., and Keyl, A. C. 1969. Toxicity of methylimidazoles. Toxicol. Appl. Pharmacol. 14:301-307.
14. Ray, A. C., Raisor, M. J., Herd, D. B., Murphy, M. J., and Reagor, J. C. 1984. Methylimidazole content of ammoniated forages associated with toxicity in cattle. Am. Assoc. Vet. Lab. Diag. Annu. Proc. 337-348.
15. Sivertsen, T., and Ingebrigtsen, K. 1993. Further arguments against 4-methylimidazole as causal factor in ammoniated forage toxicosis: Experimental seed-hay poisoning in young lambs. Acta Vet. Scand. 34:227-230.
16. Swenberg, J. A., Dietrich, D. R., McClain, R. M., and Cohen, S. M. 1992. Species-specific mechanisms of carcinogenesis. In Mechanisms of Carcinogenesis in risk identification, eds. H. Varnio, P. N. Magee, D. B. McGregor, and A. J. McMichael, pp. 477-500. Lyon, France: IARC.
17. Temple, A. R., Done, A. K., and Clement, M. S. 1971. Studies of glucuronidation: III. The measurement of p-nitrophenyl glucuronide. j. Lab. Clin. Med. 77:1015-1019.
18. Van Raaij, J. A. G. M., Kaptein, E., Visser, T. J., and Van Den Berg, K. J. 1993. Increased glucuronida tion of thyroid hormone in hexachlorobenzene-treated rats. Biochem. Pharmacol. 43:627-631.
19. Weiss, W. P., Conrad, H. R., Martin, C. M., Cross, R. F., and Shockey, W. L. 1986. Etiology of ammoniated hay toxicosis. J. Anim. Sci. 63:525-532.
20. Wong, J. M., and Bernhard, R. A. 1988. Effect of nitrogen source on pyrazine formation. J. Agric. Food Chem. 36:123-128.
21. Yuan, J. H., and Burka, L. T. 1995. Toxicokinetics of 4-methylimidazole in the male F344 rat. Xenobiotica 25:885-894