Retention mechanism of imidazoles in connective tissue. IV. Identification of a nucleophilic imidazolone metabolite in rats

Biological and Pharmaceutical Bulletin

Volumn 21, Issue 12, 1998, Pages 1334-1337

  Katsuji, Ohta ^a   Fukasawa, Yoshiki ^a   Yamaguchi, Jun Ichi ^a   Kohno, Yoshiro ^a   Fukushima, Kiyomi ^a   Suwa, Toshio ^a   Awazu, Shoji ^b  

^a Department of Drug Metabolism   (Japan)

^b TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Connective tissue; Covalent binding; Imidazolone; Nucleophilic metabolite; Rat

Indexed keywords

2 METHYL 4(5H) IMIDAZOLE; 2 METHYL 5(4H) IMIDAZOLE; 2 METHYLIMIDAZOLE; CARBON 14; CIMETIDINE; CYTOCHROME P450; DRUG METABOLITE; IMIDAZOLE DERIVATIVE; PROADIFEN; TRIENTINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; AORTA; ARTICLE; CONNECTIVE TISSUE; CONTROLLED STUDY; COVALENT BOND; DRUG ELIMINATION; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG METABOLISM; DRUG RETENTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MASS SPECTROMETRY; NONHUMAN; RAT; URINARY EXCRETION;

EID: 0032407203     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.21.1334     Document Type: Article

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