Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics

European Journal of Pharmaceutical Sciences

Volumn 34, Issue 2-3, 2008, Pages 149-163

  Groenendaal, Dorien ^a   Freijer, Jan ^b   Rosier, Andrea ^a   de Mik, Dennis ^a   Nicholls, Glynis ^c   Hersey, Anne ^c   Ayrton, Andrew D ^c   Danhof, Meindert ^a,b   de Lange, Elizabeth C M ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b LAP and P Consultants BV   (Netherlands)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Biophase distribution; Opioids; P glycoprotein; Pharmacokinetic pharmacodynamic modelling

Indexed keywords

ALFENTANIL; BUTORPHANOL; FENTANYL; GLYCOPROTEIN P; MIDAZOLAM; MORPHINE; NALBUPHINE; OPIATE AGONIST; SUFENTANIL; VECURONIUM;

ACTIVE TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CELL MEMBRANE TRANSPORT; COMPARTMENT MODEL; COMPUTER MODEL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG STRUCTURE; DRUG TRANSPORT; ELECTROENCEPHALOGRAPHY; IN VITRO STUDY; MALE; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STATISTICAL ANALYSIS;

ALGORITHMS; ANALGESICS, OPIOID; ANIMALS; CELL LINE; DIFFUSION; DOGS; ELECTROENCEPHALOGRAPHY; MALE; MODELS, STATISTICAL; P-GLYCOPROTEIN; PERMEABILITY; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 44349118459     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2008.03.003     Document Type: Article

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