Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum

Science

Volumn 298, Issue 5591, 2002, Pages 216-218

  Volkman, Sarah K ^a   Hartl, Daniel L ^a   Wirth, Dyann F ^a   Nielsen, Kaare M ^a   Choi, Mehee ^a   Batalov, Serge ^a   Zhou, Yingyao ^a   Plouffe, David ^a   Le Roch, Karine G ^a   Abagyan, Ruben ^a   Winzeler, Elizabeth A ^a  

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; DNA; GENES; MICROORGANISMS; PROTEINS;

POLYMORPHISM;

GENETIC ENGINEERING;

ADENINE; MEMBRANE PROTEIN; THYMINE;

DNA; GENETICS; POLYMORPHISM;

AMINO ACID COMPOSITION; ARTICLE; DNA HYBRIDIZATION; DNA MICROARRAY; GENE TARGETING; GENETIC POLYMORPHISM; GENETIC VARIABILITY; NONHUMAN; OLIGONUCLEOTIDE PROBE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM;

ANIMALS; BASE SEQUENCE; CHROMOSOMES; DNA, PROTOZOAN; GENES, PROTOZOAN; GENOME, PROTOZOAN; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; NUCLEIC ACID HYBRIDIZATION; OLIGONUCLEOTIDE PROBES; PLASMODIUM FALCIPARUM; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTOZOAN PROTEINS; SEQUENCE ANALYSIS, DNA; VARIATION (GENETICS);

INSECTA; PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0037020039     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1075642     Document Type: Article

References (16)

1. Sequence data for P. falciparum chromosomes 1, 3 through 9, and 13 can be obtained from The Sanger Institute (www.sanger.ac.uk/Projects/P_falciparum/).
2. Sequence data for P. falciparum chromosome 12 can be obtained from the Stanford Genome Technology Center (www-sequence.stanford.edu/group/malaria).
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16. Supported by NIH grant GM61351 (S.K.V., D.L.H., and D.F.W.); Burroughs Wellcome Fund New Initiatives in Malaria Research Award; Ellison Medical Foundation, Program in Career Development, Research and Training in Global Infectious Diseases (D.L.H. and D.F.W.); ExxonMobil Program on Malaria in Africa (D.F.W.); and a new scholars award from the Ellison Medical Foundation (E.A.W.). We wish to thank the scientists and funding agencies comprising the International Malaria Genome Sequencing Project for making sequence data from the genome of P. falciparum (3D7) public prior to publication of the completed sequence, The Sanger Centre (UK) provided sequence for chromosomes 1, 3 through 9, and 13, with financial support from the Wellcome Trust. A consortium composed of The Institute for Genome Research, along with the Naval Medical Research Center (USA), sequenced chromosomes 2, 10, 11, and 14, with support from NIAID/NIH, the Burroughs Wellcome Fund, and the U.S. Department of Defense. The Stanford Genome Technology Center (USA) sequenced chromosome 12, with support from the Burroughs Wellcome Fund.