Sympatric Plasmodium falciparum isolates from Venezuela have structured var gene repertoires

Malaria Journal

Volumn 2, Issue , 2003, Pages 1-6

  Tami, Adriana ^a   Ord, Rosalynn ^a   Targett, Geoffrey A T ^a   Sutherland, Colin J ^a  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROCYTE MEMBRANE PROTEIN 1; MEMBRANE PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOMAL LOCALIZATION; COMBINATORIAL CHEMISTRY; CONTROLLED STUDY; GENE SEQUENCE; GENOTYPE; MOLECULAR CLONING; NONHUMAN; PLASMODIUM FALCIPARUM; POLYMERASE CHAIN REACTION; POLYMORPHIC LOCUS; PROTEIN DOMAIN; PROTOZOAL GENETICS; SEQUENCE ANALYSIS; STRAIN DIFFERENCE; SYMPATRY; VAR GENE; VENEZUELA;

EID: 3042642140     PISSN: 14752875     EISSN: None     Source Type: Journal    
DOI: 10.1186/1475-2875-2-1     Document Type: Article

References (15)

1. Su X-Z, Heatwole VM, Wertheimer SP, Guinet F, Herrfeldt JA, Peterson DS, Ravetch JA and Wellems TE A large and diverse gene family (var) encodes 250-300 kD proteins implicated in the antigenic variation and cytoadherence of Plasmodium falciparum-infected erythrocytes Cell 1995, 82:89-100
2. Sutherland CJ The flip-side of cytoadherence: Immune selection, antigenic variation and the var genes of Plasmodium falciparum Parasitol Today 1998, 14:329-332
3. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE and Bowman S Genome sequence of the human malaria parasite Plasmodium falciparum Nature 2002, 419:498-511
4. Taylor HM, Kyes SA, Harris D, Kriek N and Newbold CI A study of var gene transcription in vitro using universal var gene primers Mol Biochem Parasitol 2000, 105:13-23
5. Taylor HM, Kyes SA and Newbold CI Var gene diversity is generated by frequent recombination events Mol Biochem Parasitol 2000, 110:391-397
6. Kirchgatter K, Mosbach R and del Portillo HA Plasmodium falciparum: DBL-1 var sequence analysis in field isolates from Central Brazil Exp Parasitol 2000, 95:154-157
7. Fowler EV, Peters JM, Gatton ML, Chen N and Cheng Q Genetic diversity of the DBLα region in P lasmodium falciparum var genes among Asia-Pacific isolates Mol Biochem Parasitol 2002, 120:117-126
8. Aguir JC, Albrecht GR, Cegielski P, Greenwood BM, Jensen JB, Lallinger G, Martinez A, McGregor IA, Minjas JN, Neequaye J, Patarroyo ME, Sherwood JA and Howard RJ Agglutination of Plasmodium falciparum-infected erythrocytes from East and West African isolates by human sera from distant geographic regions Am J Trop Med Hyg 1992, 47:621-632
9. Giha HA, Theander TG, Staalsoe, Roper C, Elhassan IM, Babiker H, Satti GMH, Arnot DE and Hviid L Seasonal variation in agglutination of Plasmodium falciparum-infected erythrocytes Am J Trop Med Hyg 1998, 58:399-405
10. Bull PC, Lowe BS, Kortok M, Molyneux CS, Newbold CI and Marsh K Parasite antigens on the infected red cell surface are targets for naturally acquired immunity to malaria Nature Med 1998, 4:358-360
11. Gupta S, Maiden MCJ, Feavers IM, Nee S, May RM and Anderson RM The maintenance of strain structure in populations of recombining infectious agents Nature Med 1996, 2:437-442
12. Tami A, Grundmann H, Sutherland C, McBride JS, Cavanagh DR, Campos E, Snounou G, Barnabe C, Tibayrenc M and Warhurst DC Restricted genetic and antigenic diversity of Plasmodium falciparum under mesoendemic transmission in the Venezuelan Amazon Parasitology 2002, 124:569-581
13. Bland M In: An Introduction to Medical Statistics OUP Oxford 1987, Chapter 6, sect 64:
14. Freitas-Junior LH, Bottius E, Pirrit LA, Deitsch KW, Scheidig C, Guinet F, Nehrbass U, Wellems TE and Scherf A Frequent ectopic recombination of virulence factor genes in telomeric chromosome clusters of P. falciparum. Nature 2000, 407:1018-1022
15. Vazquez-Macias A, Martinez-Cruz P, Castaneda-Patian MC, Scheidig C, Gysin J, Scherf A and Hernandez-Rivas R A distinct 5′ flanking var gene region regulates Plasmodium falciparum variant erythrocyte surface antigen expression in placental malaria Mol Microbiol 2002, 45:155-167