Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues

British Journal of Cancer

Volumn 73, Issue 10, 1996, Pages 1233-1236

  Chui, X ^a   Egami, H ^a   Yamashita, J ^a   Kurizaki, T ^a   Ohmachi, H ^a   Yamamoto, S ^a   Ogawa, M ^a  

^a KUMAMOTO UNIV SCHOOL OF MEDICINE   (Japan)

Author keywords

Breast cancer; c kit proto oncogene product; Immunohistochemistry

Indexed keywords

STEM CELL FACTOR;

ARTICLE; BREAST; BREAST CANCER; BREAST DISEASE; CANCER CELL; CELL MEMBRANE; CONTROLLED STUDY; GROWTH REGULATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL CARCINOMA; MALIGNANT TRANSFORMATION; ONCOGENE C KIT; PRIORITY JOURNAL; PROTO ONCOGENE; SIGNAL TRANSDUCTION;

EID: 0030013525     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.236     Document Type: Article

References (14)

1. d mutant. Cell, 64, 1025-1035.
2. JAPANESE BREAST CANCER SOCIETY. (1992). General Rules for Clinical and Pathological Recording of Breast Cancer. 11th edn. Kanehara: Tokyo.
3. KESHET E, LYMAN SD, WILLIAMS DE, ANDERSON DM, JENKINS NA, COPELAND NG AND PARADA LF. (1991). Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development. EMBO J., 10, 2425-2435.
4. MATSUDA R, TAKAHASHI T, NAKAMURA S, SEKIDO Y, NISHIDA K, SETO M, SEITO T, SUGIURA T, ARIYOSHI Y, TALAHASHI T AND UEDA R. (1993). Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues. Am. J. Pathol., 142, 339-346.
5. NATALI PG, NICOTRA MR, SURES I, SANTORO E, BIGOTTI A AND ULLRICH A. (1992a) Expression of c-kit receptor in normal and transformed human nonlymphoid tissues. Cancer Res., 52, 6139-6143.
6. NATALI PG, NICOTRA MR, SURES I, MOTTOLESE M, BOTTI C AND ULLRICH A. (1992b). Breast cancer is associated with loss of the c-kit oncogene product. Int. J. Cancer, 52, 713-717.
7. NATALI PG, NICOTRA MR, WINKLER AB, CAVALIERE R, BIGOTTI A AND ULLRICH A. (1992c). Progression of human cutaneous melanoma is associated with loss of expression of c-kit protooncogene receptor. Int. J. Cancer, 52, 197-201.
8. NOGUCHI S, MOTOMURA K, INAJI H, IMAOKA S AND KOYAMA H. (1992). Clonal analysis of human breast cancer by means of polymerase chain reaction. Cancer Res., 52, 6594-6597.
9. NOGUCHI S, MOTOMURA K, INAJI H, IMAOKA S AND KOYAMA H. (1994). Clonal analysis of predominantly intraductal carcinoma and precancerous lesions of the breast by means of polymerase chain reaction. Cancer Res., 54, 1849-1853.
10. QIU F, RAY P, BROWN K, BARKER PE, JHANWAR S, RUDDLE FH AND BESMER P. (1988). Primary structure of c-kit: relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J., 7, 1003-1011.
11. REITH AD, ELLIS C, LYMAN S, ANDERSON DM, WILLIAMS DE, BERNSTEIN A AND PAWSON T. (1991). Signal transduction by normal isoforms and W mutant variants of the kit receptor tyrosine kinase. EMBO J., 10, 2451-2459.
12. REMMELE W AND STEGNER HE. (1986). Immunohistochemischer Nachweis von Östrogenrezeptroren (ERICA) in Mammakarzinomgewebe: Vorschlag zur Einheitlichen Formulierung des Untersuchungsbefundes. Dtsch. Ärztebl., 83, 3362-3364.
13. STROHMEYER T, PETER S, HARTMANN M, MUNEMITSU S, ACKERMANN R, ULLRICH A AND SLAMON DJ. (1991). Expression of the hst-1 and c-kit protooncogenes in human testicular germ cell tumors. Cancer Res., 51, 1811-1816.
14. WERSHIL BK, TSAI M, GEISSLER W, ZSEBO KM AND GALLI SJ. (1992). The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function. J. Exp. Med., 175, 245-255.