New PPARγ ligands based on 2-hydroxy-1,4-naphthoquinone: Computer-aided design, synthesis, and receptor-binding studies

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 11, 2008, Pages 3192-3195

  Sundriyal, Sandeep ^a   Viswanad, Bhoomi ^a   Bharathy, Elumalai ^a   Ramarao, Poduri ^a   Chakraborti, Asit K ^a   Bharatam, Prasad V ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

2 Hydroxy 1,4 naphthoquinone; Computer aided drug design; Docking; Farglitazar; Glitazones; PPAR ; Rosiglitazone

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 3 HYDROXY 1,4 NAPHTHOQUINONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PIOGLITAZONE; 2,4 THIAZOLIDINEDIONE DERIVATIVE; LIGAND; NAPHTHOQUINONE;

ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; NONHUMAN; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; COMBINATORIAL CHEMISTRY; COMPUTER AIDED DESIGN; DRUG POTENTIATION; MOUSE; PROTEIN BINDING; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

MURINAE;

ANIMALS; COMBINATORIAL CHEMISTRY TECHNIQUES; COMPUTER-AIDED DESIGN; DRUG DESIGN; LIGANDS; MICE; MOLECULAR STRUCTURE; NAPHTHOQUINONES; PPAR GAMMA; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 44249125968     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.04.072     Document Type: Article

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