The anti-apoptotic effect of IGF-1 on tissue resident stem cells is mediated via PI3-kinase dependent secreted frizzled related protein 2 (Sfrp2) release

Biochemical and Biophysical Research Communications

Volumn 371, Issue 4, 2008, Pages 752-755

  Gehmert, Sebastian ^a   Sadat, Sanga ^a   Song, Yao Hua ^a   Yan, Yasheng ^a   Alt, Eckhard ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Apoptosis; IGF 1; Stem cells

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; BETA CATENIN; PHOSPHATIDYLINOSITOL 3 KINASE; SECRETED FRIZZLED RELATED PROTEIN 2; SMALL INTERFERING RNA; SOMATOMEDIN C;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL HYPOXIA; CELL NUCLEUS; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SERUM; STEM CELL; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOSE TISSUE; ANIMALS; APOPTOSIS; BETA CATENIN; CELL HYPOXIA; CELL SURVIVAL; CHROMONES; INSULIN-LIKE GROWTH FACTOR I; MEMBRANE PROTEINS; MICE; MORPHOLINES; PROTEIN KINASE INHIBITORS; STEM CELLS; UP-REGULATION;

EID: 44149107068     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.151     Document Type: Article

References (25)

1. Anversa P., Leri A., Kajstura J., and Nadal-Ginard B. Myocyte growth and cardiac repair. J. Mol. Cell Cardiol. 34 (2002) 91-105
2. Assmus B., Schachinger V., Teupe C., Britten M., Lehmann R., Dobert N., Grunwald F., Aicher A., Urbich C., Martin H., Hoelzer D., Dimmeler S., and Zeiher A.M. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 106 (2002) 3009-3017
3. Perin E.C., Dohmann H.F., Borojevic R., Silva S.A., Sousa A.L., Mesquita C.T., Rossi M.I., Carvalho A.C., Dutra H.S., Dohmann H.J., Silva G.V., Belem L., Vivacqua R., Rangel F.O., Esporcatte R., Geng Y.J., Vaughn W.K., Assad J.A., Mesquita E.T., and Willerson J.T. Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation 107 (2003) 2294-2302
4. Stamm C., Westphal B., Kleine H.D., Petzsch M., Kittner C., Klinge H., Schumichen C., Nienaber C.A., Freund M., and Steinhoff G. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361 (2003) 45-46
5. Strauer B.E., Brehm M., Zeus T., Kostering M., Hernandez A., Sorg R.V., Kogler G., and Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106 (2002) 1913-1918
6. Wollert K.C., Meyer G.P., Lotz J., Ringes-Lichtenberg S., Lippolt P., Breidenbach C., Fichtner S., Korte T., Hornig B., Messinger D., Arseniev L., Hertenstein B., Ganser A., and Drexler H. Intracoronary autologous bone-marrow cell transfer after myocardial infarction: the BOOST randomised controlled clinical trial. Lancet 364 (2004) 141-148
7. Toma C., Pittenger M.F., Cahill K.S., Byrne B.J., and Kessler P.D. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 105 (2002) 93-98
8. Zhang M., Methot D., Poppa V., Fujio Y., Walsh K., and Murry C.E. Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies. J. Mol. Cell Cardiol. 33 (2001) 907-921
9. Buerke M., Murohara T., Skurk C., Nuss C., Tomaselli K., and Lefer A.M. Cardioprotective effect of insulin-like growth factor I in myocardial ischemia followed by reperfusion. Proc. Natl. Acad. Sci. USA 92 (1995) 8031-8035
10. Li Q., Li B., Wang X., Leri A., Jana K.P., Liu Y., Kajstura J., Baserga R., and Anversa P. Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. J. Clin. Invest. 100 (1997) 1991-1999
11. Matsui T., Li L., del Monte F., Fukui Y., Franke T.F., Hajjar R.J., and Rosenzweig A. Adenoviral gene transfer of activated phosphatidylinositol 3'-kinase and Akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation 100 (1999) 2373-2379
12. Fujio Y., Nguyen T., Wencker D., Kitsis R.N., and Walsh K. Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart. Circulation 101 (2000) 660-667
13. Kanemitsu N., Tambara K., Premaratne G.U., Kimura Y., Tomita S., Kawamura T., Hasegawa K., Tabata Y., and Komeda M. Insulin-like growth factor-1 enhances the efficacy of myoblast transplantation with its multiple functions in the chronic myocardial infarction rat model. J. Heart Lung Transplant 25 (2006) 1253-1262
14. Kofidis T., de Bruin J.L., Yamane T., Balsam L.B., Lebl D.R., Swijnenburg R.J., Tanaka M., Weissman I.L., and Robbins R.C. Insulin-like growth factor promotes engraftment, differentiation, and functional improvement after transfer of embryonic stem cells for myocardial restoration. Stem Cells 22 (2004) 1239-1245
15. Mangi A.A., Noiseux N., Kong D., He H., Rezvani M., Ingwall J.S., and Dzau V.J. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat. Med. 9 (2003) 1195-1201
16. Mirotsou M., Zhang Z., Deb A., Zhang L., Gnecchi M., Noiseux N., Mu H., Pachori A., and Dzau V. Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair. Proc. Natl. Acad. Sci. USA 104 (2007) 1643-1648
17. Song Y.H., Gehmert S., Sadat S., Pinkernell K., Bai X., Matthias N., and Alt E. VEGF is critical for spontaneous differentiation of stem cells into cardiomyocytes. Biochem. Biophys. Res. Commun. 354 (2007) 999-1003
18. Sadat S., Gehmert S., Song Y.H., Yen Y., Bai X., Gaiser S., Klein H., and Alt E. The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF. Biochem. Biophys. Res. Commun. 363 (2007) 674-679
19. Bai X., Sadat S., Gehmert S., Alt E., and Song Y.H. VEGF receptor Flk-1 plays an important role in c-kit expression in adipose tissue derived stem cells. FEBS Lett. 581 (2007) 4681-4684
20. Conacci-Sorrell M., Zhurinsky J., and Ben-Ze'ev A. The cadherin-catenin adhesion system in signaling and cancer. J. Clin. Invest. 109 (2002) 987-991
21. Satyamoorthy K., Li G., Vaidya B., Patel D., and Herlyn M. Insulin-like growth factor-1 induces survival and growth of biologically early melanoma cells through both the mitogen-activated protein kinase and beta-catenin pathways. Cancer Res. 61 (2001) 7318-7324
22. Hahn J.Y., Cho H.J., Bae J.W., Yuk H.S., Kim K.I., Park K.W., Koo B.K., Chae I.H., Shin C.S., Oh B.H., Choi Y.S., Park Y.B., and Kim H.S. Beta-catenin overexpression reduces myocardial infarct size through differential effects on cardiomyocytes and cardiac fibroblasts. J. Biol. Chem. 281 (2006) 30979-30989
23. Lee J.L., Lin C.T., Chueh L.L., and Chang C.J. Autocrine/paracrine secreted Frizzled-related protein 2 induces cellular resistance to apoptosis: a possible mechanism of mammary tumorigenesis. J. Biol. Chem. 279 (2004) 14602-14609
24. Melo L.G., Pachori A.S., Kong D., Gnecchi M., Wang K., Pratt R.E., and Dzau V.J. Molecular and cell-based therapies for protection, rescue, and repair of ischemic myocardium: reasons for cautious optimism. Circulation 109 (2004) 2386-2393
25. Iso Y., Spees J.L., Serrano C., Bakondi B., Pochampally R., Song Y.H., Sobel B.E., Delafontaine P., and Prockop D.J. Multipotent human stromal cells improve cardiac function after myocardial infarction in mice without long-term engraftment. Biochem. Biophys. Res. Commun. 354 (2007) 700-706