Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2

Journal of Biological Chemistry

Volumn 283, Issue 14, 2008, Pages 9177-9186

  Harita, Yutaka ^a,b   Kurihara, Hidetake ^c   Kosako, Hidetaka ^a   Tezuka, Tohru ^a   Sekine, Takashi ^b   Igarashi, Takashi ^b   Hattori, Seisuke ^a,d  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d KITASATO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; CHEMICAL REACTIONS; DIAPHRAGMS; DIFFUSERS (OPTICAL); ENZYME ACTIVITY; FLOW INTERACTIONS; POROUS MATERIALS;

ADAPTOR PROTEINS; BINDING MOTIFS; CYTOPLASMIC DOMAINS; ERK ACTIVATIONS; IN VITRO; IN VIVO MODELS; IN-VIVO; INHIBITORY EFFECTS; INTACT CELLS; LYSATES; PEPTIDE MASS FINGERPRINTING; PROTEIN INTERACTIONS; SH2 DOMAINS; SIGNALING NETWORKS; SLIT DIAPHRAGMS; SRC FAMILIES; STRUCTURAL FRAMEWORKS; TYROSINE KINASES; TYROSINE PHOSPHORYLATION SITES; TYROSINE PHOSPHORYLATIONS; WIDE SPECTRUMS;

PHOSPHORYLATION;

GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE FYN; PROTEIN TYROSINE KINASE; FYN PROTEIN, HUMAN; FYN PROTEIN, RAT; GRB2 PROTEIN, HUMAN; GRB2 PROTEIN, RAT; KIRREL PROTEIN, HUMAN; MEMBRANE PROTEIN; NEPH1 PROTEIN, RAT; NEPHRIN; PEPTIDE; PROTEIN TYROSINE KINASE C SRC; PROTEIN-TYROSINE KINASE C-SRC; TRANSIENT RECEPTOR POTENTIAL CHANNEL C; TRPC6 PROTEIN, HUMAN; TRRP6 PROTEIN, RAT;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MALE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL LINE; DISEASE MODEL; GENETICS; KIDNEY DISEASE; METABOLISM; METHODOLOGY; PATHOLOGY; PEPTIDE MAPPING; PHOSPHORYLATION; PROTEIN MOTIF; RAT; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAIN; WISTAR RAT;

RATTUS;

AMINO ACID MOTIFS; ANIMALS; CELL LINE; DISEASE MODELS, ANIMAL; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GRB2 ADAPTOR PROTEIN; HUMANS; KIDNEY DISEASES; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; PEPTIDE MAPPING; PEPTIDES; PHOSPHORYLATION; PODOCYTES; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS C-FYN; RATS; RATS, WISTAR; SRC HOMOLOGY DOMAINS; TRPC CATION CHANNELS;

EID: 44049087922     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M707247200     Document Type: Article

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